Analysis of common causes of liver damage among children 12 years and younger in Weifang

Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most common causes of infectious liver damage were viral infection (1515 cases), Mycoplasma pneumoniae infection (343 cases), and bacterial infection (197 cases). The most common causes of viral liver damage were Epstein–Barr virus, cytomegalovirus, and enterovirus. The most common causes of non-infectious liver damage were drug-induced liver damage, Kawasaki disease, and genetic metabolic diseases. There were 31 cases of severe liver damage. Conclusion There were many causes of liver damage among children in Weifang. Infections, and especially viral infections such as Epstein–Barr virus, were the most common causes of liver damage. Severe liver damage was primarily caused by drugs or poisons.

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Post-transfusion hepatitis in a London hospital: results of a two-year prospective study

Journal of Hygiene ◽

10.1017/s0022172400024001 ◽

1974 ◽

Vol 73 (2) ◽

pp. 173-188 ◽

Cited By ~ 30

Author(s):

Keyword(s):

Hepatitis B ◽

Epstein Barr Virus ◽

Virus Infections ◽

Cmv Infection ◽

Drug Induced ◽

Barr Virus ◽

Hepatitis B Antigen ◽

Post Transfusion Hepatitis ◽

Epstein Barr ◽

Enzyme Changes

SUMMARYSeven hundred and sixty-eight patients were seen and tested at frequent intervals after transfusion of whole blood. Eight patients were judged to have developed icteric or anicteric post-transfusion viral hepatitis, an incidence of 1%. Five were icteric and four of these were hepatitis B antigen (HB Ag) positive; two of these four died. One of the fatal cases and one non-fatal HB Ag positive case had received HB Ag positive blood. Two other antigen-positive patients had received blood or plasma or both which had not been tested for antigen.Thirty-five patients showed conspicuous or sustained elevations of alanine transaminase without clinical features of hepatitis.Four were positive for HB Ag but had not received antigen positive blood.Two who had received antigen positive blood remained antigen negative, but one developed hepatitis B antibody (HB Ab).Two other patients were also transfused with plasma.Five had serological evidence of cytomegalovirus (CMV) infection accompanying the enzyme changes.One patient who had received HB Ag positive blood remained antigen-negative and showed no abnormalities.Five patients who became HB Ag positive, although they had been given antigen-negative blood, remained clinically and biochemically well.Cytomegalovirus primary infection or reactivation occurred in another 32 patients; five had isolated, transient enzyme rises, one other was associated with a drug-induced focal liver necrosis and 26 showed no enzyme changes. Epstein–Barr virus infections, one of which was associated with a transient upset of enzyme activity, were detected in five patients. There were no cases of post-perfusion syndrome.

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Drug-induced hypersensitivity syndrome associated with primary Epstein-Barr virus and human herpesvirus 6 infections in a child intestinal transplant recipient

Transplantation Journal ◽

10.1097/01.tp.0000102459.25647.c6 ◽

2004 ◽

Vol 77 (3) ◽

pp. 479 ◽

Cited By ~ 5

Author(s):

Emmanuel Mahé ◽

Christine Bodemer ◽

Laurent Dupic ◽

Philippe Hubert ◽

Florence Lacaille ◽

...

Keyword(s):

Transplant Recipient ◽

Epstein Barr Virus ◽

Human Herpesvirus ◽

Hypersensitivity Syndrome ◽

Human Herpesvirus 6 ◽

Drug Induced ◽

Barr Virus ◽

Herpesvirus 6 ◽

Epstein Barr ◽

Intestinal Transplant

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T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.

Journal of Experimental Medicine ◽

10.1084/jem.184.5.1791 ◽

1996 ◽

Vol 184 (5) ◽

pp. 1791-1800 ◽

Cited By ~ 121

Author(s):

E Scotet ◽

J David-Ameline ◽

M A Peyrat ◽

A Moreau-Aubry ◽

D Pinczon ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

T Cell ◽

Epstein Barr Virus ◽

Large Fraction ◽

T Cell Response ◽

Unknown Etiology ◽

Rheumatoid Arthritis Pathogenesis ◽

Chronic Rheumatoid Arthritis ◽

Barr Virus ◽

Epstein Barr

Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.

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Multiviral reactivation of human herpesvirus (HHV)-6, HHV-7, cytomegalovirus, and Epstein-Barr virus in drug-induced hypersensitivity syndrome

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2004.10.540 ◽

2005 ◽

Vol 52 (3) ◽

pp. P133

Keyword(s):

Epstein Barr Virus ◽

Human Herpesvirus ◽

Hypersensitivity Syndrome ◽

Drug Induced ◽

Barr Virus ◽

Epstein Barr

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Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Science ◽

10.1126/science.abj8222 ◽

2022 ◽

Author(s):

Kjetil Bjornevik ◽

Marianna Cortese ◽

Brian C. Healy ◽

Jens Kuhle ◽

Michael J. Mina ◽

...

Keyword(s):

Multiple Sclerosis ◽

Epstein Barr Virus ◽

Demyelinating Disease ◽

Serum Levels ◽

Unknown Etiology ◽

Neurofilament Light Chain ◽

Neurofilament Light ◽

Barr Virus ◽

The Central Nervous System ◽

Epstein Barr

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.

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Drug-Induced Hypersensivity Syndrome Associated with Epstein-Barr Virus Infection: A Pediatric Case Report

Pediatric Dermatology ◽

10.1111/j.1525-1470.2009.00891.x ◽

2009 ◽

Vol 26 (2) ◽

pp. 229-231 ◽

Cited By ~ 5

Author(s):

PAOLA SCAGNI ◽

MAURA MORELLO ◽

MARISA VIETTI RAMUS ◽

MANUELA AGOSTINI ◽

ROSAURA PAGLIERO

Keyword(s):

Case Report ◽

Virus Infection ◽

Epstein Barr Virus ◽

Epstein Barr Virus Infection ◽

Pediatric Case ◽

Drug Induced ◽

Barr Virus ◽

Epstein Barr ◽

Barr Virus Infection

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Nanomembrane-based Apheresis as Safe and Effective Therapy for Cytomegalovirus and Epstein-Barr Virus Reactivation

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.7534 ◽

2021 ◽

Vol 9 (C) ◽

pp. 258-262

Author(s):

Vjeroslava Slavic ◽

Beti Djurdjic ◽

Danijela Randjelovic ◽

Gordana Rajovic ◽

Marina Delic

Keyword(s):

Case Report ◽

Liver Damage ◽

Epstein Barr Virus ◽

Abdominal Ultrasound ◽

Viral Reactivation ◽

Marathon Running ◽

Virus Reactivation ◽

Barr Virus ◽

Epstein Barr ◽

Transient Elevation

BACKGROUND: Heavy training schedules or endurance competitions in marathon are forms of extreme physical stress and lead to immunodepression in runners which could be associated with increased susceptibility to viral reactivation by ubiquitous viral infection such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Lately, it was confirmed presence of elevated CMV and EBV loads and the lower antibody titers in competitive athletes. The most common clinical features are fatigue and adynamia accompanied with liver damage, varying from mild and transient elevation of aminotransferases to serious acute hepatitis and liver failure. CASE REPORT: Bearing in mind that a professional practice of marathon running is hazardous for the liver, therapeutic action is necessary as soon as possible to avoid serious complications and even cessation of professional competition. In our case report of professional female marathon runner, we need to treat CMV and EBV reactivation which caused liver damage, prevented regular trainings, and upcoming competitions. We opted for four sessions of nanomembrane based apheresis performed every other day for removal pathological products resulting from virus reactivation to break through the course of the disease and to prevent complications. After completing the whole procedure control laboratory tests and abdominal ultrasound were in physiological ranges. CONCLUSION: Hence, nanomembrane based apheresis can be effective and safe treatment of liver damages for elite marathon runners as well as for athletes.

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Inflammatory pseudotumor of the spleen

Vojnosanitetski pregled ◽

10.2298/vsp0608757c ◽

2006 ◽

Vol 63 (8) ◽

pp. 757-760 ◽

Cited By ~ 2

Author(s):

Natasa Colovic ◽

Radoje Colovic ◽

Nikica Grubor ◽

Marijan Micev ◽

Vladimir Radak ◽

...

Keyword(s):

World Literature ◽

Lymphoproliferative Disorder ◽

Epstein Barr Virus ◽

Inflammatory Pseudotumor ◽

Unknown Etiology ◽

Left Shoulder ◽

Exact Nature ◽

Barr Virus ◽

Inflammatory Pseudotumors ◽

Epstein Barr

Background. Inflammatory pseudotumors are benign tumor lesions of an unknown etiology that can appear almost at any organ, sometimes along with infectious agens, like Epstein-Barr virus. They are extremely rare in the spleen, with less than 80 cases described in the world literature. It is a single, very rarely multinodal lesion. Middle aged patients are mostly affected. Symptoms are either absent or uncharacteristic, so that the tumors are discovered by chance or during investigations of other diseases. Case report. We presented a 56-year-old woman in whom a nodal lesion of 2 cm in diameter had been discovered in the spleen during a routine check-up after a mild traffic accident. The lesion had grown up to 6 cm in diameter during a 5-year follow-up causing a mild pain over the upper left abdomen and left shoulder. Fine needle biopsy failed to show the exact nature of the lesion. Splenectomy was performed due to a suspected lymphoproliferative disorder. Histology and immunohistochemistry of the lesion of the upper pole of the spleen showed inflammatory pseudotumor. Epstein-Barr virus was not present. The patient developed postsplenectomy thrombocytosis (up to 850 ? 109/l) which settled down within 10 weeks. Conclusion. Inflammatory pseudotumors of the spleen are extremely rare. The exact diagnosis can be established only by histology and/or immunohistochemistry of the spleen removed for a suspected lymphoproliferative disorder, most frequently lymphoma. The patient was cured with splenectomy.

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Rare case of Visceral form of Infectious Mononucleosis in Irkutsk Region

Acta biomedica scientifica ◽

10.29413/abs.2018-3.6.24 ◽

2019 ◽

Vol 3 (6) ◽

pp. 164-167

Author(s):

N. K. Bobrova ◽

E. Yu. Zorkaltseva

Keyword(s):

Infectious Mononucleosis ◽

Epstein Barr Virus ◽

Clinical Symptoms ◽

Hypochromic Anemia ◽

Symptomatic Treatment ◽

Neural System ◽

Unknown Etiology ◽

Barr Virus ◽

Leading Role ◽

Epstein Barr

Infectious mononucleosis (MI) is caused by the Herpes viridae family of viruses. Currently, most researchers assign a leading role to the Epstein-Barr virus. In present time there are no unified clinical classification of infection mononucleosis, but many authors recognize the visceral form which involves cardiovascular system, adrenal glands, lungs, central neural system and others organs. The article describes a clinical case of MI in the 28-year-old patient. She applied for medical help with complaints of fever up to 39 °C, weakness in the legs and arms, weight loss and received symptomatic treatment on an outpatient department. After 2 months on the background of deterioration, she was hospitalized in an infectious diseases hospital with severe symptoms of intoxication, lymphoproliferative syndrome, myocarditis, pericarditis, hepatitis, polyneuropathy with quadriparesis, hypochromic anemia, thrombocytopenia. She was consulted by an oncologist and diagnosed with cervical cancer. Laboratory confirmation was obtained – Epstein-Barr virus was detected in the blood. Against the background of antiviral therapy, a regression of clinical symptoms was achieved in a week. The patient was transferred to a oncological hospital. It is recommended to examine patients with high fever of unknown etiology on myocardial infarction for the timely appointed etiotropic therapy.

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