scholarly journals Hierarchical Modeling as the Basis of Technology of Preclinical Testing Blood Glucose Level Control Algorithms

2017 ◽  
Vol 2017 (1(187)) ◽  
pp. 80-95 ◽  
Author(s):  
S. KIFORENKO
2020 ◽  
Vol 20 (08) ◽  
pp. 2050055
Author(s):  
URSULE ESSAMBA MAH ◽  
PAUL WOAFO

This paper deals with the numerical simulation of a model of blood glucose level control of a diabetic person using an electrodynamic transducer. Two mathematical models describing the dynamics of the couple glucose–insulin are used: the Bergman’s and the Cheng’s models. First, the adaptive control is applied on the dynamics of a reservoir opener by an electrodynamic transducer. Then it is applied on the two models of the glucose–insulin dynamics. It is found that the control of the reservoir opener and that of the glycemia of a diabetic patient are efficient for some values of the control parameters.


2015 ◽  
Vol 70 (5) ◽  
pp. 549-560 ◽  
Author(s):  
V. A. Karpel’ev ◽  
Yu. I. Filippov ◽  
Yu. V. Tarasov ◽  
M. D. Boyarsky ◽  
A. Yu. Mayorov ◽  
...  

Interest in the mathematical modeling of the carbohydrate metabolism regulation system increases in recent years. This is associated with a «closed loop» insulin pump development (it controls an insulin infusion depending on the blood glucose level). To create an algorithm for the automatic control of insulin (and other hormones) infusion using an insulin pump it is necessary to accurately predict glycaemia level. So, the primary objective of mathematical modeling is to predict the blood glucose level changes, caused by the wide range of external factors. This review discusses the main mathematical models of blood glucose level control physiological system (simplified insulin–glucose system). The two major classes of models — empirical and theoretical — are described in detail. The ideal mathematical model of carbohydrate metabolism regulatory system is absent. However, the success in the field of blood glucose level control modeling and simulating is essential for the further development of diabetes prevention and treatment technologies, and creating an artificial pancreas in particular.


2019 ◽  
pp. 52-56
Author(s):  
Yu.F. Glukhov ◽  
N.V. Krutikov ◽  
A.V. Ivanov ◽  
N.P. Muravskaya

We have studied and analyzed status and metrological supervision of blood glucose monitors, individual devices for a person’s blood glucose level measurement. It has been indicated that nowadays blood glucose monitors like other individual devices for medical measurement are not allowed to be involved in telemedicine public service. This accounts for absence of metrological supervision with these measurement devices in telemedicine. In addition, the key problem is absence of safe methods and means of remote verificaition, calibration and transmission of measurement data to health care centers. The article offers a remote test method for blood glucose monitors using a number of resistors with values correlating with measured blood glucose level. The available method has been successfully trialed in real practice.


2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>


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