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Author(s):  
Ahmad Khusairi Azemi ◽  
Sagir Mustapha ◽  
Mustapha Mohammed ◽  
Aida Hanum Ghulam Rasool ◽  
Reezal Ishak ◽  
...  

Diabetes mellitus remains a major risk factor for developing cardiovascular diseases, resulting in increased morbidity and mortality associated with cardiovascular complications. Given the burden of diabetes-related cardiovascular complications, there is a need to identify strategies, safe and effective therapeutic agents that could effectively prevent and control diabetes. Presently, many patients living with diabetes depends on traditional medicines as an alternative cure. Channa striatus (Haruan) is a freshwater fish traditionally used to treat wounds, inflammations, and pains. Several pharmacological investigations have supported the folkloric claims of C. striatus extracts, including hypoglycemic, hypolipidemic, antioxidant, anti-inflammatory, and pro-platelet aggregation activities. The therapeutic potentials of C. striatus were demonstrated to be associated with the presence of high content essential amino acids and good fatty acids known to improve cell growth and facilitate wound healing. Therefore, C. striatus bioactive compounds have great potentials to serve as lead candidates in developing novel therapeutic agents for the management of diabetes and related cardiovascular diseases. This review aims to provide a comprehensive overview of the pharmacological properties and therapeutic potentials of C. striatus for the management of diabetes and associated cardiovascular complications.


Author(s):  
Hossein Bahrami Moghadam ◽  
Mahmood Maniati

The new coronavirus pneumonia, which first occurred in China in December 2019, has a wide spectrum of symptoms from asymptomatic to very severe involvement and even death. The main reason for the increase in the severity of this disease is the body's inflammatory response to the virus, and due to the lack of effective antiviral treatment for this disease, it is necessary to take therapeutic interventions to reduce the body's inflammatory response. It is noteworthy that diabetic patients are more severely exposed to this disease and this calls for appropriate treatment to control diabetes in patients with COVID19. In addition to its antioxidant and anti-inflammatory effects, alpha lipoic acid also has therapeutic effects in controlling diabetes and blood sugar. Therefore, it is suggested that clinical trials be performed to evaluate the effects of alpha-lipoic acid on diabetic patients with COVID19


2021 ◽  
Author(s):  
Lexi Huang ◽  
Yihan Zhang ◽  
Guanhua Fan

BACKGROUND In China, diabetes has become much more common over the past three decades. The latest statistics on chronic diseases in China (2013) as well as the attendant risk factors, as reported by JAMA (2017), reveal that among Chinese adults, the standardized prevalence of diagnosed and undiagnosed diabetes is 10.9% (95% CI: 10.4%–11.5%) and that of prediabetes is 35.7% (95% CI: 34.1%–37.4%). By 2020, an estimated 155 million (10.9% of the population) will have a diabetes diagnosis, and App507 million (35.7%) will have a prediabetes diagnosis. Diabetes, as a chronic disease, requires medical treatment and self-management—such as adjustments to diet and physical activity. Because of the large clinical workload and hectic work schedule of Chinese health care providers, who primarily focus on treatment, crucial elements in health education are neglected and many patients do not have a personalized self-management plan designed by their health care provider. Furthermore, health care providers find it difficult to empathize with their patients emotionally and provide them prompt mental health care. In addition, health care providers, being busy, tend to be unavailable to calibrate their patients’ self-management plan and address problems as soon as they occur. ICT-based diabetes management tools have thus emerged as substitutes for health care providers, providing solutions tailored to the needs of each patient. China, in particular, has become the most promising market for self-management tools. OBJECTIVE To summarize the functions of representative ICT tools in China; analyze these tools’ effectiveness with reference to the literature; compare these AppAppstools with respect to their functions qualitatively and quantitatively; and finally, discuss the status, attendant risks, and further research directions regarding diabetes online communities. METHODS The most commonly used diabetes self-management Applications (DMAs) were searched for using the term “diabetes” in Apple’s App Store and MyApp (a widely used Android App store in China). The Apps’ basic information and main functions were then recorded. In the page for each App in the App stores, two investigators individually analyzed 99 randomly selected user comments, where keyword modifiers were coded. Each user comment was assigned a score, which was then aggregated. User comments were also coded with respect to 11 App functions. The scores for each App function and for the App as a whole Apps were analyzed using the Kruskal–Wallis test. Common online forums (Baidu Tieba, Sweet Home, and Zhihu) were selected according to user volume, number of posts, and depth of discussion. Social media platforms (WeChat and QQ) were selected according to download volume and number of related articles. The basic information and main functions of the forums and social media platforms were also collected and compared with those of the DMAs. The last section of this article reviews the literature on the effectiveness of the specific Apps analyzed here. RESULTS The functions of the ICT tools differed in their form, quality, and advantages offered. Peer communication is the common feature among the Apps. Welltang and DNurse were perceived most and least favorably overall, respectively (p = .024). Regarding App functions, Control Diabetes had the highest score for functions pertaining to diet, blood glucose management, and family support. The Apps did not significantly differ with respect to diabetes education and ancillary functions. Regarding diet management functionality, Control Diabetes scored the highest, primarily because it can recommend recipes, whereas Tang Tang Quan scored the lowest (p = .000). For drug management functionality, Da Tang Yi scored the highest, and Tang Tang Quan scored the lowest (p = .013). All Apps have a drug recording function, and Da Tang Yi scored the highest primarily because only it can remind users to take their medication. For blood glucose management functionality, Control Diabetes scored the highest, significantly higher than DNurse (p = .007) and Tang Tang Quan did (p = .013), possibly because of Control Diabetes’s ability to measure the user’s blood glucose and remind them to do so. For peer communication functionality, Tang Tang Quan was scored much higher than the other Apps (p = .000). We attribute this to the App being developed by the Tang Tang Quan online community, which has a larger user base and greater App development experience. Users trust Tang Tang Quan because it affords peer interaction. For doctor consultation functionality, Welltang scored the highest, whereas DNurse scored the lowest (p = .000). For family support functions, Control Diabetes scored the highest, whereas Tang Tang Quan scored the lowest (p = .026), possibly because of Tang Tang Quan’s complex binding process. Regarding functions classified as “other,” Tang Tang Quan and DNurse differed significantly (P = .027). “This version of Tang Tang Quan is well-optimized” and “operation is easy” are the most frequently used phrases in the comments. Users are deterred from using an App because of privacy concerns, lack of user friendliness, excessive advertisements, and inaccurate measurements by supporting equipment, which, in turn, reduce compliance. All ICT-based tools, except Baidu Tieba, Zhihu, and Da Tang Yi App, have been shown to improve diabetes self-management previously. CONCLUSIONS Each ICT-based tool has unique functionality that brings unique advantages to users in a given aspect of diabetes self-management. The supplementary functions of DMAs (e.g., recommending recipes and reminding users to take their medication or measure their blood glucose) distinguished the DMAs from each other in the function score. Although there are many ICT-based tools in the market, only a small proportion of them have been demonstrated to be effective, and the quality of research is poor. Therefore, high-quality randomized controlled trials are needed to establish the criteria for the design of ICT-based tools.


Author(s):  
Amit Chandra Deshmukh ◽  
Li Youqiang

The motive of this study was to find out the effect of Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) on Diabetes Mellitus (T2D). For the purpose of this study 200 subjects were selected and divided into two groups from Delhi, India. Both groups are experimental groups. In each group, 100:100 Type 2 Diabetes Mellitus (T2DM) subjects were distributed. There were 50 females and 50 males in each group i.e. half of the each group was female. The subjects’ age ranged between 35-45 years. One group was engaged in Chain Yogic Exercise (Yogasana) and the other group was perform Yogic Therapy (Agnisar Kriya), This process was for 90 days (30-30-30 days). The data was collected on the first day (dated 16th September 2020) of 1st round as pre-test and on the last day (dated 16th October 2020) of 1st round as post-test. For statistical analysis and interpretation of data, paired t-Test was employed. The level of significance had been taken 0.05 and 0.01. The study found Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) both has a significant effect to control Diabetes Mellitus (T2D). The study also found that Yogic Therapy (Agnisar Kriya) had much better effect to control Diabetes Mellitus (T2D) than Chain Yogic Exercise (Yogasana). <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0796/a.php" alt="Hit counter" /></p>


2021 ◽  
Vol 20 ◽  
Author(s):  
Daniela Gonçalves Gonçalves Barros ◽  
Kássylla Ferreira dos Santos ◽  
Juliana de Oliveira Roque e Lima ◽  
Suelen Gomes Malaquias ◽  
Ana Luiza Lima Sousa ◽  
...  

Objetivo: Descrever os cuidados com o uso de insulinas disponibilizadas pelo SUS e analisar os fatores associados aos cuidados inadequados. Método: Estudo transversal com 113 pessoas com Diabetes Mellitus de um ambulatório de Goiânia-GO. Foram coletados dados em prontuários sobre conservação, preparo e administração de insulina que foram classificados em adequados e inadequados. Resultados: Do total de participantes,58,4% eram mulheres e a média de idade foi 48 anos. Hipertensão arterial foi relatada por 70,8% e 89,0% apresentaram hemoglobina glicada ≥7%. A totalidade dos usuários de insulina realizavam pelo menos um tipo de cuidado inadequado e 62,8% realizavam quatro ou mais. Os mais frequentes foram:conservarem locais não recomendados (46,7%), não aplicar insulina 30 minutos antes da refeição (87,5%), não avaliar presença de grumos no frasco de insulina NPH (71,9%) e não retirar a insulina da geladeira entre 15 e 30 minutos antes da aplicação (88,7%). Não houve diferença estatisticamente significante com as variáveis de exposição analisadas, porém a maior proporção de quatro ou mais cuidados inadequados ocorreu nas mulheres, nos jovens, naqueles com 11 ou mais anos de estudo, tempo de doença superior a 10 anos e, entre os que aplicam insulina uma ou duas vezes ao dia. Conclusão: Houve alta prevalência de cuidados inadequados e grande variabilidade de práticas, reforçando a importância da implementação da linha de cuidados em Diabetes Mellitus em todos os níveis de atenção à saúde


Author(s):  
Misbah Sultana ◽  
Saima Jadoon ◽  
Arif Malik

Background: Pancreatic β-cells for insulin secretion are the main regulators of mammalian metabolic process. Diabetes and hyperglycemia make the patient dependable on exogenous insulin, which is due to the lack of functional β-cells. Oxidative stress also play an important role in the aggravation of this pathological condition. Recent insights into the development of β-cells along with the pluripotent stem cells discovery have opened new ways to generate β-cells that can help in the screening of various drugs and also in the transplantation therapy since, these pluripotent Embryonic Stem Cells (ESCs) can develop in any type of cell, due to which any defective tissue can be substituted. Objectives: The objective of this study was to evaluate current strategies which can help to control diabetes mellitus. Methodology: Methodological approach of this review was based on the comparison of theoretical studies and researches related to diabetes mellitus. Results: In vitro or in vivo replication might be repeated based on proteins or through small molecules. Efforts have been made through which differentiated cells can be converted into β-cells by transcriptional regulators that are the significant players for the development, as well as responsible to identify conditions that cause replication of β-cell both in vitro and in vivo. The recent strategies can be applied for new β-cells generation and also highlights the future aspects regarding the mechanisms that govern later differentiation stages. Conclusion: This review provides an update on generating β-cells from different strategies and also brief about the development and function of β-cells that how they could help to control diabetes.


Author(s):  
Pharkphoom Panichayupakaranant ◽  
Muhammad Ajmal Shah ◽  
Thongtham Suksawat

2020 ◽  
Vol 2 ◽  
pp. 298-302
Author(s):  
Miftah Azrin ◽  
Suyanto Suyanto

The incidence of Type 2 Diabetes Mellitus (DM) in rural areas shows an increasing number. For this reason, efforts to control diabetes need to be done through education to the public. Community service was conducted in the village of BuluhCina which is one of the fostered villages of Kampung Pelita Medika FK UNRI. Education is provided with Kukerta students through socialization of a healthy diet and checking blood sugar as a risk factor. Through this service, it is hoped that the community will have the awareness to control the risk factors for DM in BuluhCina village.


The key to successful management of any disease is its timely screening and diagnosis. Undetected and uncontrolled diabetes increases the chances of oral diseases, especially periodontitis. Chronic periodontitis and diabetes are two mutually related pathologies and are known to aggravate each other’s pathological effect. Since diabetes acts as an important risk factor for periodontal inflammation, it is essential to screen blood glucose levels to detect diabetes in patients presenting with chronic periodontitis. Periodontal inflammation produces ample gingival bleeding (gingival crevicular blood: GCB) during examination by the periodontal probe, which could be utilized to evaluate blood glucose levels and glycemic control at the dental office. Early screening and diagnosis of diabetes intervenes in the long-term complications of both the diseases and helps in better disease management. The objective of this review was to highlight the reliability and acceptability of different techniques using gingival crevicular blood for evaluation of blood glucose levels along with their advantages and limitations. By this literature review, we analysed over 60 studies published regarding the use of gingival crevicular blood for screening diabetes in periodontitis patients. The data was gathered via Google scholar and Medline using the keywords “Periodontitis, Inflammation, Glycemic control, Diabetes, Gingival crevicular blood” from the years 1993-2019. Keywords: Periodontitis; Inflammation; Glycemic Control; Diabetes; Gingival Crevicular Blood


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