The The efficiency of antihypoxants for prophylactic use on the model of toxic pulmonary edema caused by the use of nitrogen oxide (IV) was studied. It was found that the antihypoxants amtizol (25 mg/kg) and cytoflavin (100 mg/kg for succinic acid), increase the daily survival of rats have a pronounced anti-edematous action. The use of cytoflavin and amtizol increased the daily survival rate to 50 and 40%, respectively. Antihypoxants amtizol and cytoflavin decreased the pulmonary coefficient and the degree of hydration of the lungs, increased the dry residue of the lungs. The coefficient of protection for cytoflavin was 1.33 and 1.28 for amtizol. The use of succinic acid at a dose of 25 and 100 mg/kg did not lead to a higher daily survival rate of the animals and significant change in gravimetric parameters in comparison with the control group.
Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives
