scholarly journals Synthesis of Amino Acid Precursors from Simulated Interstellar Media by High-Energy Particles or Photons

2007 ◽  
Vol 127 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Kensei Kobayashi ◽  
Tomoya Ogawa ◽  
Hisako Tonishi ◽  
Takeo Kaneko ◽  
Yoshinori Takano ◽  
...  
Keyword(s):  
Amino Acid ◽  
High Energy ◽  
Interstellar Media ◽  
Amino Acid Precursors ◽  
High Energy Particles

Synthesis of amino acid precursors from simulated interstellar media by high-energy particles or photons

2008 ◽  
Vol 91 (3) ◽  
pp. 15-21 ◽  
Author(s):  
Kensei Kobayashi ◽  
Tomoya Ogawa ◽  
Hisako Tonishi ◽  
Takeo Kaneko ◽  
Yoshinori Takano ◽  
...  
Keyword(s):  
Amino Acid ◽  
High Energy ◽  
Interstellar Media ◽  
Amino Acid Precursors ◽  
High Energy Particles

Formation of Organic Compounds in Simulated Interstellar Media with High Energy Particles

1997 ◽  
Vol 70 (5) ◽  
pp. 1021-1026 ◽  
Author(s):  
Takashi Kasamatsu ◽  
Takeo Kaneko ◽  
Takeshi Saito ◽  
Kensei Kobayashi
Keyword(s):  
Organic Compounds ◽  
High Energy ◽  
Interstellar Media ◽  
High Energy Particles

scholarly journals Formation of amino acid precursors with large molecular weight in dense clouds and their relevance to origins of bio-homochirality

2008 ◽  
Vol 4 (S251) ◽  
pp. 465-472 ◽  
Author(s):  
Kensei Kobayashi ◽  
Takeo Kaneko ◽  
Yoshinori Takano ◽  
Jun-ichi Takahashi
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Cosmic Rays ◽  
Organic Compounds ◽  
Uv Light ◽  
High Energy ◽  
Interstellar Space ◽  
Molecular Weights ◽  
Before And After ◽  
Amino Acid Precursors

AbstractA wide variety of organic compounds have been found in carbonaceous chondrites and comets, which suggests that extraterrestrial organic compounds could have been an important source of the first terrestrial biosphere. In the Greenberg model, these organic compounds in the small bodies were originally formed in interstellar dusts (ISD) in dense clouds by the action of cosmic rays and ultraviolet light. We irradiated a frozen mixture of methanol, ammonia and water with high-energy heavy ions from an accelerator (“HIMAC” in NIRS, Japan) to simulate the action of cosmic rays in dense clouds. Racemic mixtures of amino acids were detected after hydrolysis of the irradiation products. A mixture of carbon monoxide, ammonia and water also gave such complex amino acid precursors with large molecular weights. When such amino acid precursors were irradiated with circular polarized UV light from a synchrotron, enantiomeric excesses were detected. The yield of amino acids was not largely changed between, before, and after CPL-irradiation. The present results suggest that the seed of homochirality of terrestrial amino acids were originally formed in interstellar space.

Observation of High-Energy Particles in the Inner Radiation Belt by the HEP Instrument of the Arase Satellite

2020 ◽  
Vol 18 (6) ◽  
pp. 398-403
Author(s):  
Honoka TODA ◽  
Wataru MIYAKE ◽  
Takefumi MITANI ◽  
Takeshi TAKASHIMA ◽  
Yoshizumi MIYOSHI ◽  
...  
Keyword(s):  
Radiation Belt ◽  
High Energy ◽  
High Energy Particles

scholarly journals B0AT1 amino acid transporter complexed with SARS-CoV-2 receptor ACE2 forms a heterodimer functional unit: in situ conformation using radiation inactivation analysis

Function ◽  
2021 ◽  
Author(s):  
Bruce R Stevens ◽  
J Clive Ellory ◽  
Robert L Preston
Keyword(s):  
Amino Acid ◽  
Membrane Trafficking ◽  
Functional Unit ◽  
Membrane Vesicles ◽  
High Energy ◽  
Amino Acid Transporter ◽  
Neutral Amino Acid ◽  
Transport Activity ◽  
Acid Transporter

Abstract The SARS-CoV-2 receptor, Angiotensin Converting Enzyme-2 (ACE2), is expressed at levels of greatest magnitude in the small intestine as compared to all other human tissues. Enterocyte ACE2 is co-expressed as the apical membrane trafficking partner obligatory for expression and activity of the B0AT1 sodium-dependent neutral amino acid transporter. These components are assembled as an [ACE2: B0AT1]2 dimer-of-heterodimers quaternary complex that putatively steers SARS-CoV-2 tropism in the gastrointestinal (GI) tract. GI clinical symptomology is reported in about half of COVID-19 patients, and can be accompanied by gut shedding of virion particles. We hypothesized that within this 4-mer structural complex, each [ACE2: B0AT1] heterodimer pair constitutes a physiological “functional unit.” This was confirmed experimentally by employing purified lyophilized enterocyte brush border membrane vesicles that were exposed to increasing doses of high-energy electron radiation from a 16 MeV linear accelerator. Based on established target theory, the results indicated the presence of Na+-dependent neutral amino acid influx transport activity functional unit with target size mw = 183.7 ± 16.8 kDa in situ in intact apical membranes. Each thermodynamically stabilized [ACE2: B0AT1] heterodimer functional unit manifests the transport activity within the whole ∼345 kDa [ACE2: B0AT1]2 dimer-of-heterodimers quaternary structural complex. The results are consistent with our prior molecular docking modeling and gut-lung axis approaches to understanding COVID-19. These findings advance the understanding of the physiology of B0AT1 interaction with ACE2 in the gut, and thereby potentially contribute to translational developments designed to treat or mitigate COVID-19 variant outbreaks and/or GI symptom persistence in long-haul Post-Acute Sequelae of SARS-CoV-2 (PASC).

scholarly journals Gamma-Ray and Neutrino Signals from Accretion Disk Coronae of Active Galactic Nuclei

Galaxies ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 36
Author(s):  
Yoshiyuki Inoue ◽  
Dmitry Khangulyan ◽  
Akihiro Doi
Keyword(s):  
Active Galactic Nuclei ◽  
Gamma Ray ◽  
Galactic Nuclei ◽  
High Energy ◽  
Thermal Activity ◽  
X Ray ◽  
Cascade Models ◽  
Coronal Activity ◽  
Ngc 1068 ◽  
High Energy Particles

To explain the X-ray spectra of active galactic nuclei (AGN), non-thermal activity in AGN coronae such as pair cascade models has been extensively discussed in the past literature. Although X-ray and gamma-ray observations in the 1990s disfavored such pair cascade models, recent millimeter-wave observations of nearby Seyferts have established the existence of weak non-thermal coronal activity. In addition, the IceCube collaboration reported NGC 1068, a nearby Seyfert, as the hottest spot in their 10 yr survey. These pieces of evidence are enough to investigate the non-thermal perspective of AGN coronae in depth again. This article summarizes our current observational understanding of AGN coronae and describes how AGN coronae generate high-energy particles. We also provide ways to test the AGN corona model with radio, X-ray, MeV gamma ray, and high-energy neutrino observations.

scholarly journals Arcopilus aureus MaC7A as a New Source of Resveratrol: Assessment of Amino Acid Precursors, Volatiles, and Fungal Enzymes for Boosting Resveratrol Production in Batch Cultures

2021 ◽  
Vol 11 (10) ◽  
pp. 4583
Author(s):  
Nemesio Villa-Ruano ◽  
Luis Ángel Morales-Mora ◽  
Jenaro Leocadio Varela-Caselis ◽  
Antonio Rivera ◽  
María de los Ángeles Valencia de Ita ◽  
...  
Keyword(s):  
Amino Acid ◽  
Filamentous Fungi ◽  
Hydrolytic Enzymes ◽  
Glucanase Activity ◽  
Fungal Enzymes ◽  
Activity Increase ◽  
Batch Cultures ◽  
Low Concentrations ◽  
Chemical Factors ◽  
Amino Acid Precursors

The chemical factors that regulate the synthesis of resveratrol (RV) in filamentous fungi are still unknown. This work reports on the RV production by Arcopilus aureus MaC7A under controlled conditions and the effect of amino acid precursors (PHE and TYR), monoterpenes (limonone, camphor, citral, thymol, menthol), and mixtures of hydrolytic enzymes (Glucanex) as elicitors for boosting fungal RV. Batch cultures with variable concentrations of PHE and TYR (50–500 mg L−1) stimulated RV production from 127.9 ± 4.6 to 221.8 ± 5.2 mg L−1 in basic cultures developed in PDB (pH 7) added with 10 g L−1 peptone at 30 °C. Maximum levels of RV and biomass were maintained during days 6–8 under these conditions, whereas a dramatic RV decrease was observed from days 10–12 without any loss of biomass. Among the tested volatiles, citral (50 mg L−1) enhanced RV production until 187.8 ± 2.2 mg L−1 in basic cultures, but better results were obtained with Glucanex (100 mg L−1; 198.3 ± 7.6 mg L−1 RV). Optimized batch cultures containing TYR (200 mg L−1), citral (50 mg L−1), thymol (50 mg L−1), and Glucanex (100 mg L−1) produced up to 237.6 ± 4.7 mg L−1 of RV. Our results suggest that low concentrations of volatiles and mixtures of isoenzymes with β-1, 3 glucanase activity increase the biosynthesis of fungal RV produced by A. aureus MaC7A in batch cultures.

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