Review of Microfluidic Devices for On-Chip Chemical Sensing

2016 ◽  
Vol 136 (6) ◽  
pp. 244-249
Author(s):  
Takahiro Watanabe ◽  
Fumihiro Sassa ◽  
Yoshitaka Yoshizumi ◽  
Hiroaki Suzuki
Keyword(s):  
Chemical Sensing ◽  
Microfluidic Devices ◽  
On Chip

Review of Microfluidic Devices for On-Chip Chemical Sensing

2017 ◽  
Vol 100 (4) ◽  
pp. 25-32 ◽  
Author(s):  
TAKAHIRO WATANABE ◽  
FUMIHIRO SASSA ◽  
YOSHITAKA YOSHIZUMI ◽  
HIROAKI SUZUKI
Keyword(s):  
Chemical Sensing ◽  
Microfluidic Devices ◽  
On Chip

Versatile acoustic manipulation of micro-object using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Wei Zhang ◽  
Bin Song ◽  
Xue Bai ◽  
Lina Jia ◽  
Li Song ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Oscillating Bubbles ◽  
Fixed Design ◽  
On Chip

Controllable on-chip multimodal manipulation of micro-objects in microfluidic devices is urgently required for enhancing the efficiency of potential biomedical applications. However, fixed design and driving models make it difficult to...

Design Techniques for Microfluidic Devices Implementation Applicable to Chemical Analysis Systems

2019 ◽  
pp. 195-222 ◽  
Author(s):  
Reinaldo Lucas dos Santos Rosa ◽  
Antonio Carlos Seabra
Keyword(s):  
Chemical Analysis ◽  
Solid Phase ◽  
Microfluidic Devices ◽  
Water Quality Monitoring ◽  
Analysis Process ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
On Chip ◽  
Separation Cell ◽  
High Level

This chapter provides a guide for microfluidic devices development and optimization focused on chemical analysis applications, which includes medicine, biology, chemistry, and environmental monitoring, showing high-level performance associated with a specific functionality. Examples are chemical analysis, solid phase extraction, chromatography, immunoassay analysis, protein and DNA separation, cell sorting and manipulation, cellular biology, and mass spectrometry. In this chapter, most information is related to microfluidic devices design and fabrication used to perform several steps concerning chemical analysis, process preparation of reagents, samples reaction and detection, regarding water quality monitoring. These steps are especially relevant to lab-on-chip (LOC) and micro-total-analysis-systems (μTAS). μTAS devices are developed in order to simplify analytical chemist work, incorporating several analytical procedures into flow systems. In the case of miniaturized devices, the analysis time is reduced, and small volumes (nL) can be used.

scholarly journals On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

Lab on a Chip ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 162-170 ◽  
Author(s):  
Kadi L. Saar ◽  
Yingbo Zhang ◽  
Thomas Müller ◽  
Challa P. Kumar ◽  
Sean Devenish ◽  
...  
Keyword(s):  
Electric Fields ◽  
Single Layer ◽  
Microfluidic Devices ◽  
Protein Analysis ◽  
Label Free ◽  
Free Protein ◽  
On Chip ◽  
Electrolysis Products

Single-layer lithography microfluidic devices for applying high and stable electric fields on chip.

scholarly journals Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 85 ◽  
Author(s):  
Brigitte Bruijns ◽  
Andrea Veciana ◽  
Roald Tiggelaar ◽  
Han Gardeniers
Keyword(s):  
Chemical Resistance ◽  
Multiple Displacement Amplification ◽  
Visible Region ◽  
Dna Amplification ◽  
Microfluidic Devices ◽  
Cyclic Olefin Copolymer ◽  
Color Test ◽  
Cyclic Olefin ◽  
On Chip ◽  
Amplification Reaction

Microfluidic devices offer important benefits for forensic applications, in particular for fast tests at a crime scene. A large portion of forensic applications require microfluidic chip material to show compatibility with biochemical reactions (such as amplification reactions), and to have high transparency in the visible region and high chemical resistance. Also, preferably, manufacturing should be simple. The characteristic properties of cyclic olefin copolymer (COC) fulfills these requirements and offers new opportunities for the development of new forensic tests. In this work, the versatility of COC as material for lab-on-a-chip (LOC) systems in forensic applications has been explored by realizing two proof-of-principle devices. Chemical resistance and optical transparency were investigated for the development of an on-chip presumptive color test to indicate the presence of an illicit substance through applying absorption spectroscopy. Furthermore, the compatibility of COC with a DNA amplification reaction was verified by performing an on-chip multiple displacement amplification (MDA) reaction.

scholarly journals Engineered Lateral Roughness Element Implementation and Working Fluid Alteration to Intensify Hydrodynamic Cavitating Flows on a Chip for Energy Harvesting

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 49 ◽  
Author(s):  
Moein Talebian Gevari ◽  
Ali Hosseinpour Shafaghi ◽  
Luis Guillermo Villanueva ◽  
Morteza Ghorbani ◽  
Ali Koşar
Keyword(s):  
Energy Harvesting ◽  
Microfluidic Devices ◽  
Surface Cleaning ◽  
Hydrodynamic Cavitation ◽  
Working Fluid ◽  
Wall Roughness ◽  
Cavitating Flows ◽  
Roughness Elements ◽  
Fluid Alteration ◽  
On Chip

Hydrodynamic cavitation is considered an effective tool to be used in different applications, such as surface cleaning, ones in the food industry, energy harvesting, water treatment, biomedical applications, and heat transfer enhancement. Thus, both characterization and intensification of cavitation phenomenon are of great importance. This study involves design and optimization of cavitation on chip devices by utilizing wall roughness elements and working fluid alteration. Seven different microfluidic devices were fabricated and tested. In order to harvest more energy from cavitating flows, different roughness elements were used to decrease the inlet pressure (input to the system), at which cavitation inception occurs. The implemented wall roughness elements were engineered structures in the shape of equilateral triangles embedded in the design of the microfluidic devices. The cavitation phenomena were also studied using ethanol as the working fluid, so that the fluid behavior differences in the tested cavitation on chip devices were explained and compared. The employment of the wall roughness elements was an effective approach to optimize the performances of the devices. The experimental results exhibited entirely different flow patterns for ethanol compared to water, which suggests the dominant effect of the surface tension on hydrodynamic cavitation in microfluidic channels.

Vision-Based Real-Time Microflow-Rate Control System for Cell Analysis

2016 ◽  
Vol 28 (6) ◽  
pp. 854-861 ◽  
Author(s):  
Tadayoshi Aoyama ◽  
◽  
Amalka De Zoysa ◽  
Qingyi Gu ◽  
Takeshi Takaki ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Control System ◽  
Real Time ◽  
Flow Rate ◽  
Rate Control ◽  
Microfluidic Devices ◽  
Cell Analysis ◽  
Time Flow ◽  
On Chip ◽  
Flow Rate Control

[abstFig src='/00280006/09.jpg' width='300' text='Snapshots of particle sorting experiment using our system' ] On-chip cell analysis is an important issue for microtechnology research, and microfluidic devices are frequently used in on-chip cell analysis systems. One approach to controlling the fluid flow in microfluidic devices for cell analysis is to use a suitable pumps. However, it is difficult to control the actual flow-rate in a microfluidic device because of the difficulty in placing flow-rate sensors in the device. In this study, we developed a real-time flow-rate control system that uses syringe pumps and high-speed vision to measure the actual fluid flow in microfluidic devices. The developed flow-rate control system was verified through experiments on microparticle velocity control and microparticle sorting.

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