Surgically Restoring Portal Blood Flow to the Liver in Children With Primary Extrahepatic Portal Vein Thrombosis Improves Fluid Neurocognitive Ability

PEDIATRICS ◽  
2006 ◽  
Vol 117 (3) ◽  
pp. e405-e412 ◽  
Author(s):  
C. L. Mack
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Portal Blood Flow ◽  
Portal Blood ◽  
Vein Thrombosis

scholarly journals Portal Vein Dopplerflowmetry in healthy sheep according to age

2017 ◽  
Vol 37 (10) ◽  
pp. 1172-1176 ◽  
Author(s):  
Alexandra F. Belotta ◽  
Bianca P. Santarosa ◽  
Danilo O.L. Ferreira ◽  
Sílvia M.F. Carvalho ◽  
Roberto C. Gonçalves ◽  
...  
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Portal Blood Flow ◽  
Portal Blood ◽  
Mean Values ◽  
Pulsed Doppler Ultrasound ◽  
Healthy Sheep ◽  
Vein Diameter ◽  
Congestion Index ◽  
Post Hoc

ABSTRACT: Pulsed Doppler ultrasound was used to evaluate portal blood flow, portal velocity and portal congestion index in 24 healthy sheep divided into groups (lambs, yearlings and ewes), according to age. Measurements were performed at the 11th right intercostal space using ideal insonation angle and uniform insonation method. Mean values obtained in each group were compared with one-way ANOVA, followed by Tukey post-hoc test. Portal velocity and portal blood flow were statistically similar between the groups (P>0.05). Mean portal velocity were 17.75; 17.13 and 16.75; while mean portal blood flow were 26.65; 31.04 and 24.32 for lambs, yearlings and ewes, respectively. Portal congestion index was statistically distinct between the groups and values for lambs, yearlings and ewes were 0.009; 0.058 and 0.09, respectively (P<0.01). Statistical differences were observed in portal vein diameter, portal vein area and portal congestion index between the groups, presumably due to influence of weight and not to age.

scholarly journals Correction of extrahepatic portal hypertension in pediatric patient after liver transplantation

2017 ◽  
Vol 19 (1) ◽  
pp. 47-51
Author(s):  
A. R. Monakhov ◽  
B. L. Mironkov ◽  
T. A. Dzhanbekov ◽  
K. O. Semash ◽  
Kh. M. Khizroev ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Portal Hypertension ◽  
Portal Vein ◽  
Pediatric Patient ◽  
Portal Blood Flow ◽  
Portal Blood ◽  
Positive Trend ◽  
Portal Vein Stenosis ◽  
Vein Stenosis

Introduction. Liver transplantation is a multi-component and complex type of operative treatment. Patients undergoing such a treatment sometimes are getting various complications. One of these complications is a portal hypertension associated with portal vein stenosis.Materials and methods. In 6 years after the left lateral section transplantation from living donor in a pediatric patient the signs of portal hypertension were observed. Stenosis of the portal vein was revealed. Due to this fact percutaneous transhepatic correction of portal vein stenosis was performed.Results. As a result of the correction of portal blood flow in the patient a positive trend was noted. According to the laboratory and instrumental methods of examination the graft had a normal function, portal blood flow was adequate. In order to control the stent patency Doppler ultrasound and MSCT of the abdominal cavity with intravenous bolus contrasting were performed. Due to these examinations the stent function was good, the rate of blood flow in the portal vein due to Doppler data has reached 80 cm/sec, and a decrease of the spleen size was noted.Conclusion. Diagnosis and timely detection of portal vein stenosis in patients after liver transplantation are very important for the preservation of graft function and for the prevention of portal hypertension. In order to do that, ultrasound Doppler fluorimetry examination needs to be performed to each patient after liver transplantation. In cases of violation of the blood flow in the portal vein CT angiography performance is needed. Percutaneous transhepatic stenting of portal vein is a minimally invasive and highly effective method of correction of portal hypertension. Antiplatelet therapy and platelet aggregation control are the prerequisites for successful stent function.

scholarly journals Portal vein thrombosis: an emergency solution for blood flow in liver transplantation

2003 ◽  
Vol 16 (8) ◽  
pp. 598-599 ◽  
Author(s):  
Angel Bernardos ◽  
Juan Serrano ◽  
Miguel A. Gomez ◽  
Inmaculada Garcia ◽  
Maria Jesus Tamayo ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Vein Thrombosis

Clinical case of chronic portal vein thrombosis

2020 ◽  
pp. 27-41
Author(s):  
L. Zaklyakova ◽  
B. Levitan ◽  
M. Bolgova ◽  
V. Skvortsov ◽  
I. Zaklyakov
Keyword(s):  
Blood Flow ◽  
Portal Hypertension ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Oral Anticoagulant ◽  
Clinical Case ◽  
Standard Treatment ◽  
Decompensated Cirrhosis ◽  
Mechanical Trauma ◽  
Vein Thrombosis

Portal vein thrombosis (PVT) is a form of venous thrombosis that causes impaired or terminated blood flow in the portal vein. PVT is the main reason for the development of extrahepatic portal hypertension. The article presents a clinical case of chronic PVT with signs of severe portal hypertension and ascites. A feature of the case is that in a patient with suspected decompensated cirrhosis of the liver with the ineffectiveness of standard treatment, PVT was detected. The cause of PVT was mechanical trauma of the portal vein and hemocoagulation thrombophilia. For health reasons, the patient was prescribed rivaroxaban. Rivaroxaban is an oral anticoagulant from the group of Xa inhibitors. Against the background of treatment, recanalization of PVT was noted in the patient. Our experiment has shown that rivaroxaban is a promising drug for treatment of PVT.

scholarly journals The Influence of Portal Deviation on the Effect of Repeat Dearterializations of a Transplantable Adenocarcinoma to the Rat Liver

HPB Surgery ◽  
1994 ◽  
Vol 8 (1) ◽  
pp. 37-41
Author(s):  
L. Q. Wang ◽  
B. G. Persson ◽  
S. Bengmark
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Liver Damage ◽  
Tumour Growth ◽  
Portal Blood Flow ◽  
Therapeutic Benefit ◽  
Portal Blood ◽  
Liver Tumours ◽  
Experimental Liver

As liver tumours receive some of their blood supply from the portal vein, we wanted to illustrate the influence of portal blood flow in combination with dearterialization in the treatment of liver tumours. Forty male, inbred Wistar/Furth rats with an adenocarcinoma transplanted to the liver were treated with various inflow occlusions repeated daily for 5 days. Deviation of the portal blood flow alone with an end-side porto-caval shunt did not alter the tumour growth (p = 0.089). Thirty min of repeat dearterializations was potentiated by portal deviation so that tumour growth was delayed (p = 0.004). However, repeat dearterializations for 60 min in portal deviated rats induced irreversible liver damage and all rats died in a few days. Repeated dearterializations for 60 minutes alone retarded the tumour growth as efficiently (p = 0.007). Simultaneous occlusion of the hepatic artery and the portal vein for 30 minutes with a side-side porto-caval shunted (total devascularization) did not affect tumour growth (p = 0.154). Liver aminotransferases (ASAT and ALAT) were substantially increased following dearterialization for 30 min in rats with either an end-side or a side-side porto-caval shunt. Dearterialization for 60 min in rats with end-side porto-caval shunts gave a further release of ASAT and ALAT.In conclusion, portal deviation did not augment the therapeutic benefit of repeat dearterializations for the treatment of this experimental liver tumour. Repeat dearterializations alone seemed to be a feasible and efficient therapy for liver tumours.

scholarly journals Duplex doppler sonography in portal hypertension

2007 ◽  
Vol 60 (3-4) ◽  
pp. 161-167 ◽  
Author(s):  
Dijana Niciforovic ◽  
Viktor Till ◽  
Dusan Hadnadjev ◽  
Mira Govorcin ◽  
Zorka Lucic ◽  
...  
Keyword(s):  
Blood Flow ◽  
Portal Hypertension ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Doppler Ultrasonography ◽  
Doppler Sonography ◽  
Imaging Modality ◽  
Vein Thrombosis ◽  
Duplex Doppler ◽  
Duplex Doppler Sonography

Conventional echotomography and duplex Doppler ultrasonography are noninvasive imaging techniques in measurement of hepatic blood flow. In the period from February 2002 to March 2004, 29.086 patients underwent ultrasound examination at the Institute of Radiology in Novi Sad, and 17.503 presented with symptoms of gastroenterology diseases and/or hepatobiliary tract diseases. 984 patients underwent duplex Doppler sonography. This prospective study included 50 patients with suspected or confirmed diagnosis of portal hypertension. All patients were examined using Siemens Versa Pro (3.5 MHz convex probe; B-mode, color and pulse Doppler). The following parameters were evaluated: Doppler sonoscore, congestion index and portal vein thrombosis. By analyzing gathered data, the diagnosis of portal hypertension was confirmed in 10% of patients at baseline, and in 6% of patients at last follow-up, six months later. Results of this investigation demonstrate the importance of duplex Doppler ultrasonography as an excellent noninvasive diagnostic method used for visualization of the direction and velocity of blood flow, as well as presence of portal vein thrombosis. This imaging modality is used as an initial diagnostic tool in the evaluation of the portohepatic circulation, especially in portal hypertension syndrome and in suspected portal vein thrombosis. .

Variability of heart rhythm in patients with viral cirrhosis depending on types of portal blood flow

2019 ◽  
Vol 1 (8) ◽  
pp. 26-29
Author(s):  
S. V. Peshkova ◽  
M. V. Chistyakova ◽  
V. S. Barcan
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Heart Rhythm ◽  
Portal Blood Flow ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Linear Velocity ◽  
Portal Blood ◽  
Control Group ◽  
Left Ventricular Myocardium

The paper analyzes the results of examinations of 24 patients with viral cirrhosis of classes B and C according to Child-Pugh criteria. The control group consisted of 16 healthy patients. Patients with viral cirrhosis were divided into 2 groups: 1 group consisted of 14 patients with pseudonormokinetic type of portal blood flow; Group 2-10 patients with hyperkinetic type of portal blood flow with predominant acceleration of the linear velocity in the portal vein. The average age of patients was 35.2 ± 7.4 years. Left ventricular myocardium mass and left ventricular myocardium mass index were determined in all the patients; the diameter and the maximum linear velocity in the main portal vein were measured using an Artida pro Toshiba apparatus, Japan. Heart rate variability was studied at rest and in active orfhostasis using the «Neuro-Soth)program, Ivanovo. it was found that in patients with liver cirrhosis the sympathetic effects of the autonomic nervous system predominated, which coincided with the literature data. It was also shown that in patients with the pseudonormokinetic type of portal blood flow these effects were more pronounced. The relationship between HRV indices and the formation of left ventricular hypertrophy in patients with pseudo-normokinetic type of portal blood flow was revealed.

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