Genetic Mechanisms in Human Disease. Chromosomal Aberrations. Edited by M. F. Ashley Montague. Springfield, Illinois, Thomas, 1961

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 635-635
Author(s):  
Josef Warkany
Keyword(s):  
Chromosomal Aberrations ◽  
Human Disease ◽  
Standard System ◽  
Chromosomal Anomalies ◽  
Mitotic Chromosomes ◽  
Medical Journals ◽  
The Status ◽  
Genetic Mechanisms

It was a commendable effort to collect in a single volume many of the important contributions that in recent years have demonstrated chromosomal anomalies associated with constitutional disorders in man. The book contains 55 articles on this subject, all of them published previously in the Lancet or in other medical journals. Two introductory chapters deal with the status of cytogenetics in medicine and with the standard system of nomenclature of human mitotic chromosomes. The book ends with a chapter "Chromosomes for Beginners" reprinted from the Lancet.

scholarly journals Genetic Profiling of Malignant Melanoma Arising from an Ovarian Mature Cystic Teratoma: A Case Report

2021 ◽  
Vol 22 (5) ◽  
pp. 2436
Author(s):  
Kohei Nakamura ◽  
Eriko Aimono ◽  
Reika Takamatsu ◽  
Shigeki Tanishima ◽  
Tomonari Tohyama ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Homozygous Deletion ◽  
Mature Cystic Teratoma ◽  
Genetic Profiling ◽  
Improve Treatment ◽  
The Status ◽  
Genetic Mechanisms ◽  
Targeted Gene Sequencing

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare cases, malignant tumors arise from ovarian mature cystic teratoma. A variety of tumors can arise from mature cystic teratoma, among which primary malignant melanoma (MM), for which no molecular analyses such as genomic sequencing have been reported to date, is exceedingly rare, thereby limiting possible therapeutic options using precision medicine. We used targeted gene sequencing to analyze the status of 160 cancer-related genes in a patient with MM arising from an ovarian mature cystic teratoma (MM-MCT). KRAS amplification and homozygous deletion in PTEN and RB1 were detected in tumor samples collected from the patient. No KRAS amplification has been previously reported in cutaneous MM, indicating that the carcinogenesis of MM-MCT differs from that of primary cutaneous melanomas. A better understanding of the underlying genetic mechanisms will help clarify the carcinogenesis of MM-MCT. In turn, this will enable treatment with novel targeting agents as well as the initial exploration of gene-based precision oncological therapies, which aim to improve treatment outcomes for patients with this disease.

scholarly journals Debating Scientific Medicine: Homoeopathy and Allopathy in Late Nineteenth-century Medical Print in Bengal1

2012 ◽  
Vol 56 (4) ◽  
pp. 463-480 ◽  
Author(s):  
Shinjini Das
Keyword(s):  
Nineteenth Century ◽  
South Asia ◽  
Late Nineteenth Century ◽  
Medical Systems ◽  
Scientific Medicine ◽  
Medical Journals ◽  
The Status ◽  
Late Nineteenth ◽  
Print Market

AbstractThe historiography of medicine in South Asia often assumes the presence of preordained, homogenous, coherent and clearly-bound medical systems. They also tend to take the existence of a medical ‘mainstream’ for granted. This article argues that the idea of an ‘orthodox’, ‘mainstream’ named allopathy and one of its ‘alternatives’ homoeopathy were co-produced in Bengal. It emphasises the role of the supposed ‘fringe’, ie. homoeopathy, in identifying and organising the ‘orthodoxy’ of the time. The shared market for medicine and print provided a crucial platform where such binary identities such as ‘homoeopaths’ and ‘allopaths’ were constituted and reinforced. This article focuses on a range of polemical writings by physicians in the Bengali print market since the 1860s. Published mostly in late nineteenth-century popular medical journals, these concerned the nature, definition and scope of ‘scientific’ medicine. The article highlights these published disputes and critical correspondence among physicians as instrumental in simultaneously shaping the categories ‘allopathy’ and ‘homoeopathy’ in Bengali print. It unravels how contemporary understandings of race, culture and nationalism informed these medical discussions. It further explores the status of these medical contestations, often self-consciously termed ‘debates’, as an essential contemporary trope in discussing ‘science’ in the vernacular.

scholarly journals Further Progress in CCD Photometry

1993 ◽  
Vol 136 ◽  
pp. 291-303 ◽  
Author(s):  
Peter B. Stetson
Keyword(s):  
Star Clusters ◽  
Standard System ◽  
Synthetic Aperture ◽  
Ccd Photometry ◽  
Profile Fitting ◽  
The Status ◽  
Nearby Galaxies

AbstractI comment on some of the steps required to convert raw instrumental magnitudes, derived by profile-fitting or synthetic-aperture photometry from CCD images, to final calibrated photometry on a standard system. The status of the DAO program to obtain homogeneous BV photometry for star clusters and nearby galaxies will also be discussed.

scholarly journals A PROPOSED STANDARD SYSTEM OF NOMENCLATURE OF HUMAN MITOTIC CHROMOSOMES

CYTOLOGIA ◽  
1960 ◽  
Vol 25 (2) ◽  
pp. 289-291 ◽  
Author(s):  
Human Chromosomes Study Group
Keyword(s):  
Standard System ◽  
Mitotic Chromosomes

Chromosomal aberrations in human disease

1961 ◽  
Vol 31 (3) ◽  
pp. 442-470 ◽  
Author(s):  
Kurt Hirschhorn ◽  
Herbert L. Cooper
Keyword(s):  
Chromosomal Aberrations ◽  
Human Disease
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