PEDIATRIC APPLICATION OF THE RADIOIODINE (1-131) ROSE BENGAL METHOD IN HEPATIC AND BILIARY SYSTEM DISEASE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (2) ◽  
pp. 239-250
Author(s):  
William E. White ◽  
John S. Welsh ◽  
Daniel C. Darrow ◽  
Thomas M. Holder
Keyword(s):  
Liver Function ◽  
Rose Bengal ◽  
Pediatric Patients ◽  
Normal Liver ◽  
Normal Amount ◽  
Liver Uptake ◽  
System Disease ◽  
Intestinal Activity ◽  
Normal Subject ◽  
Biliary Ducts

Rose bengal tagged with radioiodine (I-131) injected in the vein of a normal subject is rapidly cleared from the blood by the liver and conveyed by the biliary ducts to the intestine. By counting the radioactivity over the heart, liver, and intestine, the liver function (rate of clearing the blood of activity and rate of liver uptake) and patency of the biliary ducts (appearance of activity in the intestines) can be assessed. Patients with hepatitis clear the blood of dye slowly and exhibit a slow liver uptake. Intestinal activity appears somewhat slower than normal but in normal amount. In patients with biliary atresia, the blood is cleared of activity somewhat more slowly than normal. Liver activity, though rising slowly, continues to increase for a much longer period of time than in the normal subject. No activity reaches the intestine. Sixty-five nose bengal studies were carried out in 50 pediatric patients. The test is of most value in evaluating the jaundiced neonate. More experience with it will be necessary to evaluate fully the usefulness of this test.

scholarly journals Individualised dosimetry and safety of SIRT for intrahepatic cholangiocarcinoma

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Kathy P. Willowson ◽  
Enid M. Eslick ◽  
Dale L. Bailey
Keyword(s):  
Liver Function ◽  
Dose Response ◽  
Intrahepatic Cholangiocarcinoma ◽  
Uptake Rate ◽  
Metabolic Response ◽  
Absorbed Dose ◽  
Normal Liver ◽  
Equivalent Uniform Dose ◽  
Liver Malignancy ◽  
Liver Uptake

Abstract Background The aim of this study was to investigate the safety and efficacy of selective internal radiation therapy (SIRT) with 90Y resin microspheres for the treatment of Intrahepatic Cholangiocarcinoma (ICC). A total of 23 SIRT procedures from 18 ICC subjects were analysed to determine a lesion-based dose/response relationship with absorbed dose measures from 90Y PET and metabolic response as measured on [18F]FDG PET. Average absorbed dose (Davg), minimum dose to 70% of the volume (D70), volume receiving at least 50 Gy (V50), biological effective dose (BED) and equivalent uniform dose (EUD), were compared to changes in metabolic volume, maximum standardised uptake value (SUVmax) and total lesion glycolysis (TLG). Dose to normal liver was assessed with changes in liver uptake rate as measured with [99mTc]mebrofenin scintigraphy for a cohort of 20 subjects with primary liver malignancy (12 ICC, 8 hepatocellular carcinoma (HCC)). Results Thirty-four lesions were included in the analysis. A relationship was found between metabolic response and both Davg and EUD similar to that seen previously in metastatic colorectal cancer (mCRC), albeit trending towards a lower response plateau. Both dose and SUV coefficient of variation within the lesion (CoVdose and CoVSUV), baseline TLG and EUD were found to be mildly significant predictors of response. No strong correlation was seen between normal liver dose and change in [99mTc]mebrofenin liver uptake rate; low baseline uptake rate was not indicative of declining function following SIRT, and no subjects dropped into the ‘poor liver function’ category. Conclusions ICC lesions follow a similar dose–response trend as mCRC, however, despite high lesion doses a full metabolic response was rarely seen. The CoV of lesion dose may have a significant bearing on response, and EUD correlated more tightly with metabolic response compared to Davg. SIRT in primary liver malignancy appears safe in terms of not inducing a clinically significant decline in liver function, and poor baseline uptake rate is not predictive of a reduction in function post SIRT.

Management of Obscurely Dilated Common Bile Duct with Normal Liver Function Tests: A Pragmatic Approach

2021 ◽  
Author(s):  
Sundeep Singh Saluja ◽  
Vaibhav Kumar Varshney ◽  
Vidya Sharada Bhat ◽  
Phani Kumar Nekarakanti ◽  
Asit Arora ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Pragmatic Approach ◽  
Normal Liver Function ◽  
Function Tests

Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic

Diagnosis ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Wycliffe Mbagaya ◽  
Joanne Foo ◽  
Ahai Luvai ◽  
Claire King ◽  
Sarah Mapplebeck ◽  
...  
Keyword(s):  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Normal Liver ◽  
Abdominal Ultrasound ◽  
Liver Function Tests ◽  
Analytical Investigation ◽  
Normal Liver Function ◽  
Rheumatology Clinic ◽  
History Of ◽  
Liver Biopsies

AbstractMacrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnecessary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Previous abdominal ultrasound and two liver biopsies carried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illustrates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroenzyme analysis potentially avoiding unnecessary invasive investigations.

Η αξιολόγηση της κάθαρσης του πράσινου της ινδοκυανίνης (ICG) προεγχειρητικά ως μέθοδος ελέγχου της ηπατικής λειτουργίας μετά ηπατεκτομή

2013 ◽  
Author(s):  
Μιχαήλ Δέρπαπας
Keyword(s):  
Liver Function ◽  
Liver Failure ◽  
Vena Cava ◽  
Normal Liver ◽  
Postoperative Liver Failure ◽  
Remnant Liver ◽  
Total Blood ◽  
Hepatic Reserve ◽  
Icg Clearance ◽  
Residual Liver Function

Purpose: Liver failure is a major cause of early mortality followinghepatectomy. The future-remnant liver function is an important factor whenassessing the risk for postoperative liver impairment. Several techniques havebeen established for this evaluation, including the ICG test. Aim of the study isto evaluate the ICG clearance in patients scheduled for liver resectionregarding perioperative and postoperative risk factors.Methods: Thirty-one patients, scheduled for liver resection, underwent theICG test. Peri-operative and postoperative variables were recorded andanalyzed using non-parametric tests.Results: Procedures extended from wedge excisions to extendedhepatectomies. Major complications included 1 case of a non-ST elevationmyocardial infarct, 1 case of inferior vena cava thrombosis, 2 cases of liverinsufficiency and 1 case of renal failure. Two patients died due to myocardialinfarction and postoperative liver failure respectively. PDR was foundpositively correlated with total blood loss, transfusion and operation duration.Conclusions: The role of residual liver function and particularly the hepaticreserve assessment on liver surgery may be of most benefit in the routinestratification of risk, enabling surgical procedures to be performed with safety.In this study, the ICG clearance markers were found significantly correlated with perioperative risk factors in histologically „normal‟ liver parenchyma.Interpretation of ICG clearance results may appraise in these patients aninadequate hepatic reserve in the remaining parenchyma postoperatively.Thus, in addition to CT volumetry, functional assessment of the hepaticreserve with ICG may persuade the preoperative planning and preventpostoperative liver failure.

scholarly journals Mildly elevated succinylacetone and normal liver function in compound heterozygotes with pathogenic and pseudodeficient FAH alleles

2018 ◽  
Vol 14 ◽  
pp. 55-58 ◽  
Author(s):  
Hao Yang ◽  
Francis Rossignol ◽  
Denis Cyr ◽  
Rachel Laframboise ◽  
Shu Pei Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Compound Heterozygotes
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