Urogenital Tract Abnormalities in Sons of Women Treated With Diethylstilbestrol

PEDIATRICS ◽  
1976 ◽  
Vol 58 (4) ◽  
pp. 505-507 ◽  
Author(s):  
Brian E. Henderson ◽  
Barbara Benton ◽  
Malcolm Cosgrove ◽  
Joyce Baptista ◽  
James Aldrich ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
In Utero ◽  
Urogenital Tract ◽  
Male Offspring ◽  
In Utero Exposure ◽  
Medical Practices ◽  
Female Genital

Since in utero exposure to diethylstilbestrol (DES) is known to cause abnormalities of the female genital tract later in life, exposed male offspring were located, surveyed by mail, and compared with unexposed male offspring from the same period and medical practices. The exposed and unexposed respondents appeared comparable and did not differ in their response to most medical questions. However, a larger proportion of exposed than of unexposed boys had experienced problems in passing urine (12.9% vs. 1.8%; P = .0003) and abnormalities of the penile urethra (4.4% vs. 0%; P = .017).

Prenatal exposure to stilbestrol and adenocarcinoma of the female genital tract: The pediatrician's responsibility

PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 456-458
Author(s):  
Lester F. Soyka
Keyword(s):  
Young Women ◽  
Genital Tract ◽  
Clear Cell ◽  
Female Genital Tract ◽  
In Utero ◽  
Vaginal Examination ◽  
Cell Type ◽  
Clear Cell Type ◽  
The Media ◽  
Female Genital

In 1970 Herbst and Scully1 reported seven cases of adenocarcinoma of the vagina in adolescents, of which six were of the clear-cell type. In a followup paper,2 an association was proposed between the occurrence of this previously rare tumor in young women and their exposure in utero to diethylstilbestrol (DES). This startling conclusion was immediately strengthened by reports of additional cases, and soon adenocarcinoma of the cervix also was linked to in utero DES exposure.3 These reports have been popularized by the media, and some obstetricians have recommended routine, repeated vaginal examination, biopsy, culposcopy, etc. for all females who were exposed in utero.4-6

scholarly journals The Influence of the Female Genital Tract on the Metabolism of Rabbit Spermatozoa II. Effect of Storage With Glucose Lactate, Bicarbonate , and Female Genital Tract Fluids

1968 ◽  
Vol 21 (5) ◽  
pp. 973 ◽  
Author(s):  
RN Murdoch ◽  
G Wite
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
In Utero ◽  
Rabbit Spermatozoa ◽  
Female Genital

In an attempt to isolate the factors responsible for altering the metabolism of spermatozoa incubated in utero, washed rabbit spermatozoa were stored in vitro for 6 hr at 37�C with either glucose, lactate, bicarbonate, or female genital tract fluids, and their ability to metabolize [1_14C]glucose and [6-14C]glucose was then compared with that of fresh spermatozoa.

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