Defective Polymorphonuclear Leukocyte Chemotaxis and Bactericidal Capacity in a Boy With Recurrent Pyogenic Infections

A 13-year-old boy with a history of recurrent pyogenic infections had abnormalities of polymorphonuclear leukocyte (PMN) function which probably accounted for his susceptibility to infection. PMN phagocytosis and nitroblue tetrazolium dye reduction were normal but glucose 14C oxidation was abnormally increased in resting cells. The patient's PMNs possessed decreased bactericidal activity against Staphylococcus aureus and Escherichia coli. Also documented were decreased PMN chemotactic activity and leukocyte accumulation in Rebuck skin windows. PMN random motility, PMN bone marrow reserve, PMN kinetics, lymphocyte blastogenesis, and delayed cutaneous hypersensitivity were normal. This patient represents another of the growing number of distinct granulocytopathies currently being recognized which may result in increased susceptibility to infection.

Download Full-text

Delayed Cutaneous Hypersensitivity Reactions to Hirudin

Archives of Pathology & Laboratory Medicine ◽

10.5858/2001-125-1585-dchrth ◽

2001 ◽

Vol 125 (12) ◽

pp. 1585-1587

Author(s):

Kathleen J. Smith ◽

Juan Rosario-Collazo ◽

Henry Skelton

Keyword(s):

Primary Treatment ◽

Myocardial Infarctions ◽

Hypersensitivity Reactions ◽

Type Ii ◽

Antithrombotic Agent ◽

Heparin Induced Thrombocytopenia ◽

Cutaneous Hypersensitivity ◽

History Of ◽

Delayed Hypersensitivity Reaction ◽

Delayed Cutaneous Hypersensitivity

Abstract Hirudin is one of the new synthetic antithrombin agents, which is most commonly used in patients with type II heparin-induced thrombocytopenia and in patients with hypersensitivity reactions to unfractionated heparin as well as low-molecular-weight heparins. Hirudin is comparable to heparin as an antithrombotic agent and also has been studied as a primary treatment in patients who experienced acute myocardial infarctions. We describe a patient with a history of type II heparin-induced thrombocytopenia who was placed on intravenous hirudin therapy. After extravasation of the intravenous hirudin site, the patient developed a delayed hypersensitivity reaction that histologically showed an epithelioid granulomatous infiltrate. Although rare reports of hypersensitivity reactions to hirudin have been published, these reactions have not been well characterized and the histopathologic changes have not been described.

Download Full-text

The development of delayed cutaneous hypersensitivity in rabbits infected with the herpesvirus of malignant catarrhal fever

Comparative Immunology Microbiology and Infectious Diseases ◽

10.1016/0147-9571(81)90026-6 ◽

1981 ◽

Vol 4 (1) ◽

pp. 29-34 ◽

Cited By ~ 3

Author(s):

E.Z Mushi ◽

F.R Rurangirwa

Keyword(s):

Malignant Catarrhal Fever ◽

Cutaneous Hypersensitivity ◽

Delayed Cutaneous Hypersensitivity

Download Full-text

Human Babesiosis in Europe

Pathogens ◽

10.3390/pathogens10091165 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1165

Author(s):

Anke Hildebrandt ◽

Annetta Zintl ◽

Estrella Montero ◽

Klaus-Peter Hunfeld ◽

Jeremy Gray

Keyword(s):

Clinical Management ◽

Diagnostic Tools ◽

Genetic Characteristics ◽

Susceptibility To Infection ◽

First Case ◽

The Usa ◽

Life Threatening ◽

History Of ◽

Etiological Agents ◽

Human Babesiosis

Babesiosis is attracting increasing attention as a worldwide emerging zoonosis. The first case of human babesiosis in Europe was described in the late 1950s and since then more than 60 cases have been reported in Europe. While the disease is relatively rare in Europe, it is significant because the majority of cases present as life-threatening fulminant infections, mainly in immunocompromised patients. Although appearing clinically similar to human babesiosis elsewhere, particularly in the USA, most European forms of the disease are distinct entities, especially concerning epidemiology, human susceptibility to infection and clinical management. This paper describes the history of the disease and reviews all published cases that have occurred in Europe with regard to the identity and genetic characteristics of the etiological agents, pathogenesis, aspects of epidemiology including the eco-epidemiology of the vectors, the clinical courses of infection, diagnostic tools and clinical management and treatment.

Download Full-text