Congenital Leukemia: Two Transient Regressions Without Treatment in One Patient

Congenital leukemia is a rare disorder that presents many interesting clinical features.1-4 The clinical course is generally believed to be that of rapid deterioration.2-4 We present a case report of a patient with congenital leukemia and a normal karyotype who had two spontaneous regressions of the disease. The patient later responded to treatment with the acute lymphocytic leukemia regimen and is currently in remission at the age of 48 months despite CNS relapse at the age of 22 months. CASE REPORT A white female infant was born to a healthy 32-year old gravida 2 para 2 in December 1978. Pregnancy and delivery were unremarkable.

Download Full-text

Severe Oral Mucositis in a Patient With Acute Lymphocytic Leukemia: Case Report

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2013.12.208 ◽

2014 ◽

Vol 117 (2) ◽

pp. e189

Author(s):

JEFFERSON FREIRE CARDOSO ◽

REBEKA THIARA NASCIMENTO DOS SANTOS ◽

CÉLIA MARIA BOLOGNESE FERREIRA ◽

JECONIAS CAMARA ◽

TATIANA NAYARA LIBORIO

Keyword(s):

Case Report ◽

Oral Mucositis ◽

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Severe Oral Mucositis

Download Full-text

Acute lymphocytic leukemia: Correlation of clinical features with immunocytochemical classification

American Journal of Hematology ◽

10.1002/ajh.2830250103 ◽

1987 ◽

Vol 25 (1) ◽

pp. 13-27 ◽

Cited By ~ 3

Author(s):

Bair-Her Twu ◽

Chin-Yang Li ◽

William A. Smithson ◽

H. Clark Hoagland ◽

Gordon W. Dewald

Keyword(s):

Clinical Features ◽

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia

Download Full-text

Infant Automobile Restraint Systems: Beware of the Sun

PEDIATRICS ◽

10.1542/peds.65.3.625 ◽

1980 ◽

Vol 65 (3) ◽

pp. 625-626

Author(s):

Fred Hankin ◽

Fred Vermeulen

Keyword(s):

Case Report ◽

Motor Vehicle ◽

Female Infant ◽

Insurance Companies ◽

White Female ◽

The Sun ◽

Adverse Incident ◽

Infant Safety

The use of infant safety seats in automobiles has become a standard recommendation of physicians, insurance companies, and various organizations. The efficacy of these devices in the prevention of serious motor vehicle trauma is well recognized.1-7 We report an adverse incident involving such a restraining device. CASE REPORT J.R. is a 12-week-old white female infant who was secured in such a restrainer seat in the recommended manner. The day of admission was an unusually sunny spring afternoon and the child was wearing only a T-shirt and a diaper. Persistent crying by the child for 15 minutes led to the discovery of a blister 3 cm in diameter on the exposed portion of the patient's anterior right thigh (Figure).

Download Full-text

Isolated testicular relapse in acute lymphocytic leukemia of childhood: categories and influence on survival.

Journal of Clinical Oncology ◽

10.1200/jco.1984.2.8.924 ◽

1984 ◽

Vol 2 (8) ◽

pp. 924-929 ◽

Cited By ~ 42

Author(s):

W P Bowman ◽

R J Aur ◽

H O Hustu ◽

G Rivera

Keyword(s):

Bone Marrow ◽

Complete Remission ◽

Acute Lymphocytic Leukemia ◽

Clinical Course ◽

Late Recurrence ◽

Lymphocytic Leukemia ◽

Drug Resistant ◽

Prognostic Features ◽

Resistant Disease ◽

Testicular Disease

Isolated testicular relapse complicating first hematologic remission was identified in 31 of 521 boys with acute lymphocytic leukemia (ALL). Three categories of involvement were apparent and could be related to presenting clinical features, duration of initial complete remission, and length of hematologic remission. Among 12 patients with early testicular relapse, most had unfavorable prognostic features when ALL was first diagnosed. All but two of these children experienced marrow recurrence within seven months of testicular relapse. In contrast, the 12 patients who developed testicular disease late in their clinical course have responded much better to further therapy; ten remain in bone-marrow remission for a median of four years beyond testicular relapse. Similarly, five of the seven patients with subclinical testicular leukemia, found at elective biopsy, continue in marrow remission for prolonged periods. Early testicular recurrence is a sign of drug-resistant disease; late recurrence after elective cessation of therapy may represent residual, incompletely treated but still responsive leukemia.

Download Full-text