Cefuroxime Treatment Failure and Haemophilus influenzae Meningitis: Case Report and Review of Literature

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. 132-135
Author(s):  
MOSHE ARDITI ◽  
BETSY C. HEROLD ◽  
RAM YOGEV
Keyword(s):  
Case Report ◽  
Bacterial Meningitis ◽  
Haemophilus Influenzae ◽  
Subdural Effusion ◽  
Third Generation ◽  
Review Of Literature ◽  
Single Drug ◽  
Days Of Therapy ◽  
Meningitis In Children ◽  
Third Generation Cephalosporins

Bacterial meningitis continues to be a major cause of morbidity and mortality in children despite effective antimicrobial therapy. Ampicillin and chloramphenicol have been the treatments of choice for bacterial meningitis in children older than 3 months of age, but recommendations also include cefuroxime and third-generation cephalosporins as possible single-drug alternatives. Although cefuroxime has been reported to be as effective as conventional therapy and some have recommended it for treatment of bacterial meningitis in children, there have been recent concerns about its efficacy. The purpose of this report is to describe an infant who had a relapse of Haemophilus influenzae meningitis 1 day after completing 30 days of therapy with iv cefuroxime for H influenzae meningitis complicated by sterile subdural effusion and possible osteomyelitis.

scholarly journals Emergence of Non-Serotype b EncapsulatedHaemophilus influenzaeas a Cause of Pediatric Meningitis in Northwestern Ontario

2013 ◽  
Vol 24 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Pouya Sadeghi-Aval ◽  
Raymond SW Tsang ◽  
Frances B Jamieson ◽  
Marina Ulanova
Keyword(s):  
Bacterial Meningitis ◽  
Haemophilus Influenzae ◽  
Present Article ◽  
Genetic Background ◽  
Antibiotic Sensitivity ◽  
Invasive Disease ◽  
Northwestern Ontario ◽  
Clonal Nature ◽  
Serotype B ◽  
Meningitis In Children

Before the introduction of the conjugate vaccine,Haemophilus influenzaeserotype b (Hib) was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes ofH influenzae, such as a (Hia), or f (Hif). The emergence of invasive disease caused by non-Hib in northwestern Ontario (38 cases between 2002 and 2008) with predominance of Hia was previously reported by the authors. At that time, no cases of pediatric meningitis caused byH influenzaewere recorded in the region. Continued surveillance identified 12 new cases of invasive non-Hib between January 2009 and July 2011. Among these cases, three young children developed meningitis with severe complications caused by Hia or Hif. The present article describes these cases along with the characteristics of recentH influenzaeisolates from the region, (ie, their genetic background and antibiotic sensitivity). The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasiveH influenzaeinfections in northwestern Ontario.

scholarly journals Prognosis of bacterial meningitis in children

1996 ◽  
Vol 54 (3) ◽  
pp. 407-411 ◽  
Author(s):  
Irenio Gomes ◽  
Ailton Melo ◽  
Rita Lucena ◽  
Marco Heleno Cunha-Nascimento ◽  
Adriana Ferreira ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Cranial Nerve ◽  
Cranial Nerve Palsy ◽  
Nerve Palsy ◽  
Acute Bacterial Meningitis ◽  
Subdural Effusion ◽  
Level Of Consciousness ◽  
Important Health ◽  
Meningitis In Children ◽  
The Impact

We studied the incidence and prognosis of acute neurologic complications in 281 children under 13 years of age with a diagnosis of acute bacterial meningitis. All the patients were examined daily by the same group of neurologists, using a standardized neurological examination. Patients with signs of encephalic lesions, unsatisfactory response to antibiotics or decreased level of consciousness were submitted to brain computer tomography. The overall lethality rate was 20.3% and cases whose causative agent was identified presented a higher lethality rate (23.7%) than those in which the agent was not found. The most important neurological abnormalities were meningeal signs (88.3%) followed by decreased consciousness (47.7%), irritability (35.2%), seizures (22.4%), fontanel bulging (20.6%) and cranial nerve palsy (14.2%). Seizures, cranial nerve palsy and the absence of meningeal signs were related to higher rates of lethality. Diminished consciousness, seizures, subdural effusion, abscess and hydrocephalus were the most important complications, respectively. We can conclude that acute bacterial meningitis continues to be an important health problem in developing countries and that public health measures will be necessary to minimize the impact of sequelae and reduce the mortality rate in children with that pathology.

Successful Treatment of PD Peritonitis Due to Morganella morganii Resistant to Third-Generation Cephalosporins – A Case Report

2017 ◽  
Vol 37 (2) ◽  
pp. 241-242 ◽  
Author(s):  
Vaibhav Keskar ◽  
Mohan Biyani ◽  
Syed Obaid Amin ◽  
Greg Knoll
Keyword(s):  
Peritoneal Dialysis ◽  
Case Report ◽  
Antibiotic Therapy ◽  
Successful Treatment ◽  
Third Generation ◽  
Morganella Morganii ◽  
Oral Ciprofloxacin ◽  
Microbiologic Diagnosis ◽  
Third Generation Cephalosporins

Morganella morganii is a rare cause of peritonitis in patients on peritoneal dialysis (PD). Most of the reported cases have resorted to a switch to hemodialysis. We herein report a case of peritonitis due to M. morganii resistant to third-generation cephalosporins, which was treated successfully with intraperitoneal (IP) tobramycin followed by oral ciprofloxacin. Early microbiologic diagnosis is essential in the treatment of peritonitis from rare microorganisms such as Morganella morganii, and appropriate antibiotic therapy is the key to avoiding catheter loss and subsequent switch to hemodialysis.

scholarly journals Bacterial Meningitis Caused by β-lactamase-negative, Ampicillin-resistant Nontypeable Haemophilus influenzae in a 1-year-old Girl : A Case Report

2014 ◽  
Vol 88 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Katsuaki ABE ◽  
Tadashi HOSHINO ◽  
Naoko IMUTA ◽  
Junichiro NISHI ◽  
Naruhiko ISHIWADA
Keyword(s):  
Case Report ◽  
Bacterial Meningitis ◽  
Haemophilus Influenzae
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