Bacterial Meningitis Caused by β-lactamase-negative, Ampicillin-resistant Nontypeable <i>Haemophilus influenzae </i>in a 1-year-old Girl : A Case Report

Bacterial meningitis continues to be a major cause of morbidity and mortality in children despite effective antimicrobial therapy. Ampicillin and chloramphenicol have been the treatments of choice for bacterial meningitis in children older than 3 months of age, but recommendations also include cefuroxime and third-generation cephalosporins as possible single-drug alternatives. Although cefuroxime has been reported to be as effective as conventional therapy and some have recommended it for treatment of bacterial meningitis in children, there have been recent concerns about its efficacy. The purpose of this report is to describe an infant who had a relapse of Haemophilus influenzae meningitis 1 day after completing 30 days of therapy with iv cefuroxime for H influenzae meningitis complicated by sterile subdural effusion and possible osteomyelitis.

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Ceftriaxone vs Cefotaxime for Treatment of Haemophilus influenzae Meningitis

PEDIATRICS ◽

10.1542/peds.85.4.622 ◽

1990 ◽

Vol 85 (4) ◽

pp. 622-623

Author(s):

LINDA MADSON ◽

CHARLES GROSE

Keyword(s):

Cerebrospinal Fluid ◽

Case Report ◽

Haemophilus Influenzae ◽

Treatment Failure ◽

Type B ◽

Treatment Regimens ◽

Cerebrospinal Fluid Culture ◽

Fluid Culture

To the Editor.— In a case report, Arditi et al1 d cefuroxime treatment failure in a child with Haemophilus influenzae meningitis. They substituted ceftriaxone for cefuroxime, but they did not mention that ceftniaxone treatment regimens have been associated with two problems. The first is the basis of a case report which described delayed sterilization of H influenzae type B meningitis under management with ceftriaxone.2 The infant had a positive cerebrospinal fluid culture after 3 days (six doses) of ceftriaxone.

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Haemophilus influenzaeType b Meningitis in the Short Period after Vaccination: A Reminder of the Phenomenon of Apparent Vaccine Failure

Case Reports in Infectious Diseases ◽

10.1155/2012/950107 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Noa Greenberg-Kushnir ◽

Orly Haskin ◽

Havatzelet Yarden-Bilavsky ◽

Jacob Amir ◽

Efraim Bilavsky

Keyword(s):

Bacterial Meningitis ◽

Haemophilus Influenzae ◽

Type B ◽

Vaccine Failure ◽

Time Period ◽

Short Period

We present two cases of bacterial meningitis caused byHaemophilus influenzaetype b (Hib) which developed a few days after conjugate Hib vaccination. This phenomenon of postimmunization provocative time period is reviewed and discussed. These cases serve as a reminder to clinicians of the risk, albeit rare, of invasive Hib disease in the short period after successful immunization.

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Listeria monocytogenes meningitis in an immunocompetent 18-year old patient as a possible diagnostic and therapeutical problem

Vojnosanitetski pregled ◽

10.2298/vsp1310976v ◽

2013 ◽

Vol 70 (10) ◽

pp. 976-978

Author(s):

Miodrag Vrbic ◽

Marina Dinic ◽

Maja Jovanovic ◽

Aleksandar Rankovic ◽

Lidija Popovic-Dragonjic ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Case Report ◽

Listeria Monocytogenes ◽

Bacterial Meningitis ◽

Initial Treatment ◽

Clinical Effect ◽

Complete Recovery ◽

Cell Mediated Immunity ◽

The Third ◽

Appropriate Treatment

Introduction. Listeria monocytogenes is the third most frequent cause of bacterial meningitis in adults. It commonly affects persons with defective cell-mediated immunity or advanced age, and only a few patients with no underlying predisposition have been reported. Case report. We presented an previously healthy, 18-year-old man with typical clinical features of meningitis. On the account of earlier treatment with ceftriaxone and cerebrospinal fluid finding, an assumption of partially treated bacterial meningitis was made. The initial treatment with vancomycin and ceftriaxone, substituted on day 4 with meropenem, did not produce any clinical effect. On day 6 Listeria monocytogenes was isolated and, even as late as that, the administration of ampicillin was followed by complete recovery of the patient. Conclusion. In younger, immunocompetent individuals, in spite of the existent diagnostic and therapeutic problems, the subacute course of Listeria monocytogenes meningitis provides enough time for appropriate treatment and favorable disease outcome.

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The Flu and Richard Pfeiffer

Continual Raving ◽

10.1093/oso/9780190677312.003.0002 ◽

2019 ◽

pp. 23-56

Author(s):

Janet R. Gilsdorf

Keyword(s):

Influenza Virus ◽

Bacterial Meningitis ◽

Respiratory Tract ◽

Haemophilus Influenzae ◽

Bacterial Infections ◽

Scientific Understanding ◽

Nutritional Requirements ◽

Full Potential ◽

Human Pathogen ◽

Evolutionary Patterns

For decades, scientists puzzled over which influenza virus was actually responsible for the Russian pandemic. Finally, in 2014, phylogenetic techniques (examining evolutionary patterns of the virus genes) and seroarcheologic techniques (measuring antibodies likely present in people at various points in time) were applied to the question of which virus caused the Russian flu of 1889–1892. Thus, Pfeiffer’s proclamation that his bacillus caused influenza was finally proven wrong. His identification of Bacillus influenzae in the respiratory tract, however, was a major contribution to the scientific understanding of bacterial infections and moved the field of bacteriology forward in allowing other investigators to unearth its full potential as an important human pathogen. Further, in the course of his studies of B. influenzae, Pfeiffer pioneered the field of nutritional requirements of bacteria. Finally, Pfeiffer’s identification of Haemophilus influenzae launched subsequent studies of the causes of bacterial meningitis and initiated in-depth explorations of bacterial meningitis-causing pathogens that ground our concepts of pathogenesis, and guide our management, of the infection.

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