Mitral Valve Prolapse: Associations with Symptoms and Anxiety

PEDIATRICS ◽  
1990 ◽  
Vol 85 (3) ◽  
pp. 311-315
Author(s):  
Cynthia L. Arfken ◽  
Anthony S. Lachman ◽  
Margaret J. McLaren ◽  
Peter Schulman ◽  
Charles N. Leach ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Adult Population ◽  
Systolic Murmur ◽  
Cardiac Abnormalities

Mitral valve prolapse has been studied extensively in the adult population, but less is known about it in children. Therefore, 813 children between 9 and 14 years of age were examined by a team of cardiologists and technicians. The children also responded to a questionnaire concerning the presence of symptoms and the What I Think and Feel anxiety instrument. The prevalence of mitral valve prolapse using auscultatory criteria was 4.2% (6.2% for girls, 2.3% for boys). Of those with mitral valve prolapse, 85% had a solitary click, 9% had a click and systolic murmur, and 6% had multiple clicks. Children with auscultatory mitral valve prolapse were less likely to have symptoms than those free of cardiac abnormalities. No difference in average anxiety scores was detected between the two groups. It is concluded that auscultatory mitral valve prolapse is common in children and not accompanied by an increased likelihood of symptoms or anxiety.

High-speed echophonocardiographic detection of tricuspid valve prolapse in mitral valve prolapse with discrepancy in onset of systolic murmur

1982 ◽  
Vol 103 (2) ◽  
pp. 301-303 ◽  
Author(s):  
Yoshinori L Doi ◽  
Tetsuro Sugiura ◽  
Richard L Bishop ◽  
Delores Paladino ◽  
Kathleen Moreau ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Tricuspid Valve ◽  
Mitral Valve Prolapse ◽  
High Speed ◽  
Systolic Murmur

Cardiovascular Abnormalities in Children With Fragile X Syndrome

PEDIATRICS ◽  
1993 ◽  
Vol 91 (4) ◽  
pp. 714-715
Author(s):  
Linda S. Crabbe ◽  
Lusia Hornstein ◽  
Andrew S. Bensky ◽  
David C. Schwartz
Keyword(s):  
Mitral Valve ◽  
Young Children ◽  
Fragile X Syndrome ◽  
Aortic Root ◽  
Mitral Valve Prolapse ◽  
Fragile X ◽  
Late Childhood ◽  
Childhood And Adolescence ◽  
Cardiac Abnormalities ◽  
Cardiovascular Abnormalities

It has been suggested by several authors that the prevalence of mitral valve prolapse and aortic root dilation is increased in individuals with the fragile X syndrome. The prevalence of these abnormalities in young children with fragile X has not been established. Sixteen boys and 1 girl 13 years or younger were studied. Only 1 child (6%) had the typical examination findings of mitral valve prolapse, although his echocardiogram was normal. From this study it appears that cardiac abnormalities in fragile X syndrome develop in late childhood and adolescence. It seems important to follow these children carefully so that these cardiac abnormalities can be documented when they do develop.

scholarly journals The determinants of onset of mitral valve prolapse in the systolic click-late systolic murmur syndrome.

Circulation ◽  
1976 ◽  
Vol 53 (5) ◽  
pp. 872-878 ◽  
Author(s):  
D G Mathey ◽  
P R Decoodt ◽  
H N Allen ◽  
H J Swan
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Systolic Murmur

Abstract 426: Effects of Non-syndromic Mitral Valve Prolapse on Valvular Interstitial Cell Extracellular Vesicle-associated Non-coding RNA in a Spontaneous Canine Disease Model

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Dawn Meola ◽  
Sally Robinson ◽  
Vicky Yang
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Therapeutic Potential ◽  
Adult Population ◽  
Large Population ◽  
Size Exclusion ◽  
Large Animal Model ◽  
Large Animal ◽  
Age Related ◽  
Non Coding Rna

Non-syndromic mitral valve prolapse (MVP), or Barlow’s Disease, is a valvular heart disease with a prevalence of 2-3% in the human adult population. Consequences of MVP include mitral regurgitation that without surgical treatment can progress to congestive heart failure, arrhythmias and sudden death. Since MVP is a degenerative disease that worsens with age, surgical risk is of concern with an older population, necessitating the development of alternative strategies for early detection and effective medical intervention. Similar to humans, canine MVP is age-related with a lifetime prevalence close to 90%, providing a large population for study. Canine MVP represents a relevant spontaneous large animal model to dissect the mechanistic underpinnings of disease pathogenesis and evaluate novel treatment. We hypothesize that extracellular vesicles (EVs) and their associated non-coding RNA (ncRNA) may play a role in this disease by enabling propagation of the fibroblast-to-myofibroblast phenotypic switch in mitral valvular interstitial cells (VICs). VICs were isolated from 12 normal and 14 diseased canine mitral valves and cultured in defined chemical media for 48 hours. EVs were isolated from conditioned media using size exclusion chromatography. Total RNA was isolated from EVs with the Qiagen miReasy Plasma/Serum kit, and from VIC cells with the mirVana miRNA Isolation Kit. Sequencing libraries were created using QIAseq miRNA Library Kit, and RNAseq was performed with Illumina HiSeq 2500 sequencer with single read 100 base format. Reads were mapped to canine ncRNA databases (miRbase, RFam). VICs from diseased valves had higher expression of αSMA than cells from normal valves (p = 0.002) based on RT-qPCR. Sequence analysis showed decreased content of tRNA (p = 0.023) and miRNA precursor (p = 0.036) in EVs from diseased VICs, in addition to decreased expression of let-7f. Cells from diseased valves had lower Y-RNA content (p = 0.007). miR-8859a and miR-451 were preferentially packaged into EVs from both normal and diseased VICs. Preferential packaging of miR-155 was seen in normal VIC EVs and miR-191 in diseased VIC EVs. Functional roles of these miRs will need to be confirmed to determine their therapeutic potential for treatment of MVP.

scholarly journals Autonomic support of the activity in children with small cardiac abnormalities

2019 ◽  
Vol 23 (3) ◽  
pp. 389-392
Author(s):  
A.V. Kuleshov
Keyword(s):  
Mitral Valve ◽  
Adaptive Capacity ◽  
Statistical Methods ◽  
Mitral Valve Prolapse ◽  
Orthostatic Test ◽  
Microsoft Excel ◽  
Cardiac Abnormalities ◽  
Adrenal System ◽  
Mixed Types ◽  
Autonomic Support

The aim of the study was to investigate vegetative maintenance (VM) in children with small cardiac abnormalities (SCA) using a wedge-orthostatic test (WOT). The article describes the research results of 170 children with SCA. VM was estimated with clinic orthostatic test (COT). The group of patients consisted of 106 children with mitral valve prolapse (MVP) and 64 children with false tendons (FT) in the left cardiac ventricular. We used absolute and relative statistical methods with Microsoft Excel program for this study. We found out that hypersympathycotonic type of VM was prevalent at MVP (57,6%). For FT it was only 37,5%. Pathologic type of VM with insufficient activation of sympathetic adrenal system was noted only in 21,2% of patients with SCA. This species is more common with FT (23.4%) than with MVP (19.8%). Hyper diastolic type was present only in 9,4% patients with MVP and in 3,1% with FT, respectively. Mixed types were rare noted at SCA without specification for MVP or FT (4.7% for MVP and 3.2% for FT). Thus, the revealed types of COT show the disorder of VM, which characterizes the reducing of adaptive capacity in such children.

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