Persistent Pulmonary Hypertension and ECMO

PEDIATRICS ◽  
1990 ◽  
Vol 86 (5) ◽  
pp. 809-810
Author(s):  
ELCHANAN BRUCKHEIMER ◽  
ARTHUR I. EIDELMAN
Keyword(s):  
Pulmonary Hypertension ◽  
Extracorporeal Membrane Oxygenation ◽  
Meconium Aspiration Syndrome ◽  
Persistent Pulmonary Hypertension ◽  
Major Category ◽  
Inclusion Criteria ◽  
Meconium Aspiration ◽  
Membrane Oxygenation ◽  
Respiratory Treatment ◽  
The Relationship

To the Editor.— We read with interest Dr Gross' letter1 concerning the relationship between inborn and outborn infants with persistent pulmonary hypertension and the relevance of "classical" extracorporeal membrane oxygenation (ECMO) inclusion criteria and outcome of therapy. We wholly agree with his observation that early skilled respiratory treatment of infants with persistent pulmonary hypertension to a large extent can obviate the need for ECMO, and we wish to report our experience. As has been noted, the major category of patients requiring ECMO are those with severe meconium aspiration syndrome.2

Inhaled Nitric Oxide Trials: "Vive la différence!"

PEDIATRICS ◽  
1996 ◽  
Vol 97 (3) ◽  
pp. 438-438
Author(s):  
DENNIS DAVIDSON
Keyword(s):  
Nitric Oxide ◽  
Clinical Trials ◽  
Pulmonary Hypertension ◽  
Optimal Design ◽  
Extracorporeal Membrane Oxygenation ◽  
Rescue Therapy ◽  
Underlying Disease ◽  
Inhaled Nitric Oxide ◽  
Persistent Pulmonary Hypertension ◽  
Membrane Oxygenation

The commentary by Drs Abman and Kinsella entitled "Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: The Physiology Matters!" provides one important and valid viewpoint concerning the optimal design of clinical trials in this area of neonatology. The approach that they advocate involves individualized and meticulous care of persistent pulmonary hypertension of the newborn (PPHN) patients depending on their underlying disease, using whatever conventional or rescue therapy (before extracorporeal membrane oxygenation [ECMO] is needed to support the patient, while testing the efficacy of inhaled nitric oxide (I-NO).

The Extracorporeal Membrane Oxygenation Debate

PEDIATRICS ◽  
1990 ◽  
Vol 85 (3) ◽  
pp. 381-382
Author(s):  
WILLIAM D. RHINE ◽  
ALLEN F. FISCHER ◽  
DAVID K. STEVENSON
Keyword(s):  
Pulmonary Hypertension ◽  
Extracorporeal Membrane Oxygenation ◽  
Retrospective Review ◽  
Patient Population ◽  
Recent Article ◽  
Neonatal Care ◽  
Persistent Pulmonary Hypertension ◽  
Historical Comparison ◽  
Membrane Oxygenation ◽  
Statistical Inferences

To the Editor.— We are concerned about the statistical inferences, assumptions for comparisons, and arguments of logic implicit in the recent article on survival of infants with persistent pulmonary hypertension with ECMO (extracorporeal membrane oxygenation).1 The authors did acknowledge the difficulties of retrospective review, especially over 8 years when obstetrical and neonatal care should be improving. However, other details not reported on their patient population and classification might yield important information for this historical comparison.

scholarly journals Postnatal causes and severity of persistent pulmonary Hypertension of Newborn

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Muhammad Sohail Arshad ◽  
Mudasser Adnan ◽  
Hafiz Muhammad Anwar-ul-Haq ◽  
Arif Zulqarnain
Keyword(s):  
Pulmonary Hypertension ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Birth Asphyxia ◽  
Meconium Aspiration Syndrome ◽  
Persistent Pulmonary Hypertension ◽  
High Morbidity ◽  
Meconium Aspiration

Background & Objective: Persistent pulmonary hypertension of the newborn (PPHN) is described as severe respiratory failure along with hypoxaemia. PPHN is known to be linked with high morbidity and mortality around the world. This study was planned to determine the postnatal causes and assess the severity of persistent pulmonary hypertension of newborn in babies presenting to the Children’s Hospital, Multan. Methods: This observational study was conducted at the Department of Paediatric Cardiology, The Children Hospital &Institute of Child Health, Multan, Pakistan from July to December 2019. A total of 122 confirmed cases of PPHN admitted having gestational age above 34 weeks were enrolled. Demographic data of the newborns was recorded along with maternal medical history, pregnancy status and postnatal causes of PPHN. Severity of PPHN was also recorded. Results: Out of a total of 122 cases of PPHN, 81 (66.3%) were male. Majority, 78 (64.0%) had gestational age above 37 weeks. Mode of delivery as cesarean section was noted in 70 (57.4%). Meconium aspiration syndrome 52 (42.6%), birth asphyxia 48 (39.3%), respiratory distress syndrome 23 (18.8%) and sepsis 33 (27.0%) were found to be the commonest causes of PPHN. Severe PPHN was found to be the most frequent, noted among 63 (51.6%) while Moderate PPHN was observed in 40 (32.8%) and Mild PPHN in 19 (15.6%). Morality was noted among 26 (21.3%) of cases. Conclusion: Meconium aspiration syndrome, birth asphyxia and respiratory distress syndrome were the commonest postnatal causes of PPHN. Severe PPHN was found to be the most frequent form of PPHN. doi: https://doi.org/10.12669/pjms.37.5.2218 How to cite this:Arshad MS, Adnan M, Anwar-ul-Haq HM, Zulqarnain A. Postnatal causes and severity of persistent pulmonary Hypertension of Newborn. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.2218 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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