Papillary Thyroid Cancer: A Pediatric Perspective

PEDIATRICS ◽  
1996 ◽  
Vol 98 (3) ◽  
pp. 464-466
Author(s):  
Timothy K. Flannery ◽  
John L. Kirkland ◽  
Kenneth C. Copeland ◽  
Alison A. Bertuch ◽  
Lefkothea P. Karaviti ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Carcinoma ◽  
Fine Needle Aspiration Biopsy ◽  
Case Reports ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Invasive Approach ◽  
Fine Needle ◽  
Less Invasive Approach ◽  
Children And Young Adults

A less-invasive approach to the evaluation of papillary carcinoma in children and adolescents recently has been proposed, based on reports of the accuracy and reliability of fine-needle aspiration biopsy (FNAB) in this population.1-4 Such confidence may be ill-founded, as the following clinical histories will illustrate. Functioning nodules, Hashimoto's thyroiditis (HT), and goiter-associated lymphadenopathy are unusual but significant presentations of papillary carcinoma in children and young adults, likely to be missed by the standard diagnostic approach in adults, which is reliant on FNAB, 123I scintiscans, or clinical response to suppressive doses of L-thyroxine (T4). CASE REPORTS Case 1 A thyroid nodule developed in a 12-year-old girl, first observed 1 month before evaluation in an endocrine clinic.

scholarly journals Detection of BRAF Mutation on Fine Needle Aspiration Biopsy Specimens: A New Diagnostic Tool for Papillary Thyroid Cancer

2004 ◽  
Vol 89 (6) ◽  
pp. 2867-2872 ◽  
Author(s):  
Mingzhao Xing ◽  
Ralph P. Tufano ◽  
Anthony P. Tufaro ◽  
Shehzad Basaria ◽  
Marge Ewertz ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Fine Needle Aspiration ◽  
Diagnostic Tool ◽  
Braf Mutation ◽  
Fine Needle Aspiration Biopsy ◽  
Mutation Detection ◽  
Detection Method ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle

Abstract Numerous biomolecular markers have been studied to improve the accuracy of fine needle aspiration biopsy (FNAB) in the diagnostic and prognostic evaluation of thyroid tumors, but none of them has yet become clinically useful. The recently discovered BRAF mutation, which occurs specifically in papillary thyroid cancers (PTC) with a high prevalence and is associated with poor clinicopathological outcomes, has the potential to be a useful diagnostic and prognostic marker for PTC. In the present study, we investigated whether detection of BRAF mutation on FNAB specimens was technically possible and could be used as an adjunct diagnostic tool with routine FNAB. Evaluation of a new colorimetric mutation detection method demonstrated 100% sensitivity and 100% specificity in comparison with conventional DNA sequencing as the “gold standard” in a large pool of DNA samples from various primary thyroid tumor specimens and cell lines. We found this novel technique even more sensitive in detecting BRAF mutation on FNAB specimens than conventional sequencing. In a series of 48 patients undergoing thyroidectomy, mostly for thyroid cancer or for suspicion of cancer, we performed preoperative FNAB and, using the colorimetric mutation detection method, identified BRAF mutation on the cytological specimens. Prospective analysis showed that 50% of the nodules that proved to be PTC on surgical histopathology were correctly diagnosed by BRAF mutation analysis on FNAB specimens; there were no false positive findings. Thus, we have demonstrated the usefulness of BRAF mutation detection on FNAB specimens that can help diagnose and identify those PTC patients who may need more aggressive surgical treatment and vigilant clinical monitoring.

scholarly journals An intrathyroidal nodule consisting of papillary thyroid cancer and ectopic hyperechoic parathyroid adenoma: a case report

2021 ◽  
Author(s):  
Serkan Guneyli ◽  
Adnan Kabaalioglu ◽  
Emre Altinmakas ◽  
Barbaros Erhan Cil ◽  
Orhun Cig Taskin ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Parathyroid Adenoma ◽  
Papillary Thyroid Cancer ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Neck Ultrasound ◽  
Fine Needle ◽  
Histopathologic Evaluation ◽  
Ectopic Parathyroid

A 53-year-old woman with fatigue lasting for 6 weeks and increased parathormone level underwent a neck ultrasound. It revealed a large, lobulated, solid intrathyroidal nodule consisting of hypoechoic component with microcalcifications and hy-perechoic component with vascularity on Doppler mode. There were also subcentimetric intrathyroidal hypo- and hyperechoic nodules. Upon the diagnosis of papillary thyroid cancer on fine-needle aspiration biopsy, a total thyroidectomy procedure was performed. In the histopathologic evaluation, the hypoechoic component was diagnosed as papillary thyroid cancer, while the hyperechoic component was diagnosed as ectopic parathyroid adenoma. Subcentimetric nodules were demonstrated as multi-foci of papillary thyroid cancer.

Sign in / Sign up

Export Citation Format

Share Document