Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia

Aim: Hypoxia-inducible factor 1 (HIF-1) is responsible in regulating oxygen homeostasis in tissues. HypoxiaInducible Factor α (HIF1-α) is a central effector of the hypoxic response. HIF-1α protein overexpression has been shown to have prognostic relevance in breast cancer. HIF-1α polymorphism is associated with increased breast susceptibility reported by several case controls studies but results remained controversial. Therefore, we studied the relationship between the HIF1α gene polymorphism with the breast cancer risk in Saudi Arabia. Methods: This study was consisted of 114 histologically confirmed Breast cancer patients and 117 sex -matched healthy women. HIF-1α genotyping was done by Amplification refractory mutation system PCR method. The HIF-1α gene genotypes were correlated with different clinicopathological characteristics of breast cancer patients. Results: A significant difference was observed in genotype distribution of HIF-1α gene variation C1772T between breast cancer cases and sex matched healthy controls (p=0.001). Our findings showed that the HIF- 1α variant was associated with an increased risk of Breast cancer for HIF-1α CC vs CT genotype OR = 0. 38, 95% CI = (0. 22 -0. 65), P = 0.005) in codominant inheritance model. The significant association was reported for HIF1A for genotypes CC vs (CT+ TT) OR = 0. 39, 95% CI = (0. 231 -0. 67), P = 0.007) in dominant inheritance model tested. In case of recessive inheritance model, a significant association of HIF-1 alpha gene variants was reported for CC VS -(CC+ CT) vs TT) OR = 3.10, 95% CI = (0. 12- 77.03), P = 0.56). During the allelic comparison, A allele significantly increased the risk of Breast cancer with odd ratio (OR = 0. 66, 95% CI = 0. 53 -1. 21, P = 0.04) and risk ratio RR= 0. 51 (0. 32 -0. 80) P= 0.004). A significant association of HIF1α polymorphism was reported with stage as well as distant metastasis of the disease. Conclusion: A significant association of HIF- 1α-CT heterozygosity and T allele significantly increased the susceptibility and is associated with the metastasis of Breast cancer. Further studies with larger data set and well-designed models are required to validate our findings.

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Clinical features and outcome of brain metastasis in breast cancer patients (Saudi Arabia).

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.e11516 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. e11516-e11516

Author(s):

O. A. M. Abulkhair ◽

W. K. S. Elmelouk ◽

A. Albabtain ◽

S. Musaad ◽

A. R. Jazieh

Keyword(s):

Breast Cancer ◽

Saudi Arabia ◽

Brain Metastasis ◽

Cancer Patients ◽

Clinical Features ◽

Breast Cancer Patients

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Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia

The Breast ◽

10.1016/s0960-9776(19)30321-2 ◽

2019 ◽

Vol 44 ◽

pp. S91

Author(s):

S. Elsamany ◽

A. Zeeneldin ◽

O. Elemam ◽

S. Elmorsy ◽

N. Abu Hashish

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Saudi Arabia ◽

Metastatic Breast Cancer ◽

Cancer Patients ◽

Prognostic Value ◽

Metastatic Breast ◽

Breast Cancer Patients

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Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia.

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2020.1.1.9-14 ◽

2020 ◽

Vol 1 (1) ◽

pp. 9-14

Author(s):

Shereef Elsamany ◽

Omaima Elemam ◽

Ahmed Zeeneldin ◽

Soha Elmorsy ◽

Ahmed Khatry ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Saudi Arabia ◽

Metastatic Breast Cancer ◽

Cancer Patients ◽

Prognostic Value ◽

Metastatic Breast ◽

Survival Outcome ◽

Clinicopathological Factors ◽

Breast Cancer Patients

Background Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia. Methods In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test. Results We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level. After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6). Conclusion Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.

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