scholarly journals Buschke-Löwenstein tumour (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Paulus Mario Christopher ◽  
Hartono Kosim ◽  
Ratna Sari Wijaya ◽  
Silvi Suhardi ◽  
Linda Julianti Wijayadi
Keyword(s):  
Histopathological Examination ◽  
Immune Surveillance ◽  
Basal Layer ◽  
Condyloma Acuminatum ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum ◽  
Increased Risk ◽  
Typical Morphology

Buschke Löwenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. BLT/GCA is characterized by verrucous tumor or palpable cauliflower-likemass, exophytic growth, flesh-colored, and uneven surface. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.

scholarly journals Buschke-Löwenstein tumour (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Paulus Mario Christopher ◽  
Hartono Kosim ◽  
Ratna Sari Wijaya ◽  
Silvi Suhardi ◽  
Linda Julianti Wijayadi
Keyword(s):  
Histopathological Examination ◽  
Immune Surveillance ◽  
Basal Layer ◽  
Condyloma Acuminatum ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum ◽  
Increased Risk ◽  
Typical Morphology

Buschke Löwenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. BLT/GCA is characterized by verrucous tumor or palpable cauliflower-likemass, exophytic growth, flesh-colored, and uneven surface. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.

scholarly journals Perianal Giant Condyloma Acuminatum—Buschke-Löwenstein Tumor: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Sukru Tas ◽  
Muhammet Kasim Arik ◽  
Faruk Ozkul ◽  
Oztekin Cikman ◽  
Yilmaz Akgun
Keyword(s):  
Surgical Excision ◽  
Treatment Method ◽  
Condyloma Acuminatum ◽  
Wide Resection ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum ◽  
Anogenital Region ◽  
Degree Of Malignancy

Condyloma acuminatum caused by Human Papillomavirus is the most commonly occurring sexually transmitted infection in the anogenital region. Buschke-Löwenstein tumor (BLT) known also as giant condyloma acuminatum is a rare disease. The disease, for which the most important treatment method is the surgical excision, differs from normal condyloma acuminatum cases with its high degree of malignancy. The purpose of this paper is to present the case that reached huge dimensions in the perianal region and that was treated with wide resection in the literature.

Two Cases of Giant Condyloma Acuminatum Effectively Treated with Zinc Oxide Starch Powder

2010 ◽  
Vol 72 (2) ◽  
pp. 121-125
Author(s):  
Fumiko YASUKAWA ◽  
Kyoko KUDO ◽  
Akiko NAKAMURA ◽  
Shinji KOBAYASHI ◽  
Kazunori URABE ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

scholarly journals Giant condyloma acuminatum of the vulva

2010 ◽  
Vol 14 (5) ◽  
pp. e455-e456 ◽  
Author(s):  
Xian-Jie Tan ◽  
Ming Wu ◽  
Jing-He Lang
Keyword(s):  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

Squamous-cell carcinoma of the pelvis in a giant condyloma acuminatum

1998 ◽  
Vol 41 (11) ◽  
pp. 1450-1453 ◽  
Author(s):  
Micheline Hyacinthe ◽  
Richard Karl ◽  
Domenico Coppola ◽  
Thomas Goodgame ◽  
William Redwood ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

scholarly journals Detection of Human Papillomavirus Type 56 in Giant Condyloma Acuminatum

2014 ◽  
Vol 94 (4) ◽  
pp. 482-483
Author(s):  
T Ishibuchi ◽  
A Shimizu ◽  
M Kato ◽  
Y Takeuchi ◽  
K Aoyama ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

Giant Condyloma Acuminatum

2003 ◽  
Vol 29 (3) ◽  
pp. 300-303
Author(s):  
SELMA SÖNMEZ ERGÜN ◽  
YASEMIN BALSEVER KURAL ◽  
NESIMI BÜYÜKBABANI ◽  
LEVENT VERIM ◽  
HABIB AKBULUT ◽  
...  
Keyword(s):  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

scholarly journals Surgical Management of Perianal Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor)

2006 ◽  
Vol 38 (4) ◽  
pp. 418-422 ◽  
Author(s):  
Giorgio De Toma ◽  
Giuseppe Cavallaro ◽  
Andrea Bitonti ◽  
Andrea Polistena ◽  
Maria Giuseppina Onesti ◽  
...  
Keyword(s):  
Surgical Management ◽  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

scholarly journals Sero-epidemiology and risk factors of syphilis in Makassar, Indonesia

2019 ◽  
Vol 11 (2) ◽  
pp. 43-49
Author(s):  
Maryam Kusumawaty ◽  
Khairuddin Djawad ◽  
Muh Nasrum Massi ◽  
Andi Muhammad Adam ◽  
Siswanto Wahab ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hiv Transmission ◽  
Treponema Pallidum ◽  
Public Health Problem ◽  
Sexual Relationships ◽  
Capital City ◽  
Major Public Health Problem ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Increased Risk

Abstract Introduction. Syphilis is an infectious disease caused by Treponema pallidum spirochete and is mainly transmitted by sexual contact. Syphilis has the potential to cause serious complications and is closely related to human immunodeficiency virus (HIV) infection thus making syphilis still a major public health problem. In Indonesia, surveys of high-risk populations in 2007 and 2011 reported an increase in the prevalence of syphilis, especially in men who have sexual relationships with other men (MSM). Moreover, studies have described risk factors for HIV transmission including MSM, heterosexual contacts, Intravenous (IV) drug use, and infected partners. Objectives. To assess the epidemiological aspects and risk factors for syphilis in Makassar, as well as the correlation with a coinfection of other sexually transmitted infections. Material and Methods. This study is a multi-centre cross-sectional descriptive study with consecutive sampling. We evaluated cases for eligibility by confirming the diagnosis based on the serological result using rapid plasma reagin assay (RPR), Treponema pallidum haemagglutination (TPHA), and HIV screening kit. The cases were analyzed based on epidemiological features, risk factors and clinical findings, co-infection with other sexually transmitted infection (ST), and stadium of the disease. Results. A total of 79 serologically confirmed syphilis cases were collected between January 2017 and December 2018 in Makassar, the capital city of South Sulawesi province in Indonesia. Of the 63 male subjects (79.7%), 38 (48.1%) were homosexual/MSM, and in 41 cases of HIV-infected subjects, 25 (60.9%) of them were also MSM. Conclusion. Our study showed there was a significant correlation between syphilis and an increased risk of HIV transmission in MSM groups. The higher number of cases of syphilis and HIV co-infection among MSM can increase transmission of both infections and should be considered a major risk factor for syphilis in Makassar.

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