Medical Applications of Water-Soluble Polyhydroxylated Fullerene Derivatives

1994 ◽  
Vol 359 ◽  
Author(s):  
Long Y. Chiang ◽  
Fung-Jou Lu ◽  
Jaw-Town Lin
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Water Soluble ◽  
Free Radical Scavengers ◽  
Medical Applications ◽  
Radical Scavengers ◽  
Fullerene Derivatives ◽  
Wide Range ◽  
Positive Results

ABSTRACTThe promising positive results in reducing superoxide free radicals (O2-.), generated by invitro xanthine and xanthine oxidase, have been demonstrated in the evaluation of potential uses of novel water-soluble [60] fullerenols as free radical scavengers. Observation reveals the inherent application of fullerenols in a wide range of medical and clinical areas as preventive alternatives for a long-term medical treatment.

Discovery of New N-hydrazinecarbothioamide Indazole Hybrids: As Potential Radical (ABTS and DPPH) Scavengers

2020 ◽  
Vol 17 (9) ◽  
pp. 1177-1185
Author(s):  
Rafaila Rafique ◽  
Arshia ◽  
Kanwal ◽  
Khalid Mohammed Khan ◽  
Sridevi Chigurupati ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radicals ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Synthetic Compounds ◽  
Free Radical Generation ◽  
Radical Generation

Background: Free radicals are the main cause of numerous diseases. Their overproduction needs to be controlled in order to combat several ailments. The current study deals with the discovery of new free radical scavengers. Methods: Substituted N-hydrazinecarbothioamide indazoles 1-18 were evaluated for DPPH and ABTS radical scavenging activities. Results: All synthetic compounds possess good radical DPPH and ABTS scavenging potential in the ranges of IC50 = 2.11 ± 0.17 - 5.3 ± 0.11 μM and IC50 = 2.31 ± 0.06 - 5.5 ± 0.07 μM, respectively, as compared to standard ascorbic acid having IC50 = 2.02 ± 0.11 μM for DPPH and IC50 = 2.1 ± 0.07 μM for ABTS. Conclusion: These compounds could serve as leads for antioxidant activity that have the ability to control free radical generation and ward off free radical-induced disorders.

Novel Water-soluble Hexa(sulfobutyl)fullerenes as Potent Free Radical Scavengers

1998 ◽  
Vol 27 (5) ◽  
pp. 465-466 ◽  
Author(s):  
Yu Chi ◽  
J.B. Bhonsle ◽  
Taizoon Canteenwala ◽  
Jen-Pang Huang ◽  
Jentaie Shiea ◽  
...  
Keyword(s):  
Free Radical ◽  
Water Soluble ◽  
Free Radical Scavengers ◽  
Radical Scavengers

scholarly journals Free radical scavengers can modulate the DNA-damaging action of alloxan.

2003 ◽  
Vol 50 (1) ◽  
pp. 205-210 ◽  
Author(s):  
Janusz Blasiak ◽  
Agnieszka Sikora ◽  
Agnieszka Czechowska ◽  
Józef Drzewoski
Keyword(s):  
Dna Damage ◽  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Activities ◽  
Human Lymphocytes ◽  
Dna Lesions ◽  
Dna Glycosylase ◽  
Free Radical Scavengers ◽  
Dependent Manner ◽  
Radical Scavengers

Alloxan can generate diabetes in experimental animals and its action can be associated with the production of free radicals. It is therefore important to check how different substances often referred to as free radical scavengers may interact with alloxan, especially that some of these substance may show both pro- and antioxidant activities. Using the alkaline comet assay we showed that alloxan at concentrations 0.01-50 microM induced DNA damage in normal human lymphocytes in a dose-dependent manner. Treated cells were able to recover within a 120-min incubation. Vitamins C and E at 10 and 50 microM diminished the extent of DNA damage induced by 50 microM alloxan. Pre-treatment of the lymphocytes with a nitrone spin trap, alpha-(4-pyridil-1-oxide)- N-t-butylnitrone (POBN) or ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), which mimics glutathione peroxides, reduced the alloxan-evoked DNA damage. The cells exposed to alloxan and treated with formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), enzymes recognizing oxidized and alkylated bases, respectively, displayed greater extent of DNA damage than those not treated with these enzymes. The results confirmed that free radicals are involved in the formation of DNA lesions induced by alloxan. The results also suggest that alloxan can generate oxidized DNA bases with a preference for purines and contribute to their alkylation.

Selected anthraquinones as potential free radical scavengers and P-glycoprotein inhibitors

2018 ◽  
Vol 16 (11) ◽  
pp. 1890-1902 ◽  
Author(s):  
S. Jeremić ◽  
A. Amić ◽  
M. Stanojević-Pirković ◽  
Z. Marković
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors

In this article, we estimated the scavenger capacity of six selected anthraquinones toward free radicals and their efficacy as inhibitors of P-glycoproteins.

scholarly journals Water Soluble Proteinous Substances as Free Radical-Scavengers in Fish

2007 ◽  
Vol 13 (4) ◽  
pp. 418-421
Author(s):  
Anuradha BHADRA ◽  
Yuko OOTAKE ◽  
Tomoko YAMAGUCHI ◽  
Hitoshi TAKAMURA ◽  
Teruyoshi MATOBA
Keyword(s):  
Free Radical ◽  
Water Soluble ◽  
Free Radical Scavengers ◽  
Radical Scavengers
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