Fine Chemicals Synthesis by Heterogeneous Asymmetric Catalysis

1994 ◽  
Vol 368 ◽  
Author(s):  
Kam T. Wan ◽  
Mark E. Davis
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Industrial Application ◽  
Antiinflammatory Drug ◽  
Fine Chemicals ◽  
Chiral Catalyst ◽  
Heterogeneous Asymmetric Catalysis

ABSTRACTThe application of heterogeneous asymmetric catalysis to fine chemicals synthesis is discussed. The asymmetric synthesis of naproxen, a non-steroidal antiinflammatory drug, using a novel, heterogeneous, chiral catalyst is used as an example to illustrate the feasibility to industrial application.

scholarly journals Asymmetric reactions in continuous flow

2009 ◽  
Vol 5 ◽  
Author(s):  
Xiao Yin Mak ◽  
Paola Laurino ◽  
Peter H Seeberger
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Continuous Flow ◽  
Asymmetric Reactions ◽  
Heterogeneous Asymmetric Catalysis

An overview of asymmetric synthesis in continuous flow and microreactors is presented in this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed.

scholarly journals Nitrile Synthesis with Aldoxime Dehydratases: A Biocatalytic Platform with Applications in Asymmetric Synthesis, Bulk Chemicals, and Biorefineries

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4466
Author(s):  
Pablo Domínguez de María
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Solvents ◽  
Raw Materials ◽  
Aqueous Media ◽  
Industrial Processes ◽  
Polymer Chemistry ◽  
Fine Chemicals ◽  
Mild Conditions ◽  
Bulk Chemicals ◽  
Recent Developments

Nitriles comprise a broad group of chemicals that are currently being industrially produced and used in fine chemicals and pharmaceuticals, as well as in bulk applications, polymer chemistry, solvents, etc. Aldoxime dehydratases catalyze the cyanide-free synthesis of nitriles starting from aldoximes under mild conditions, holding potential to become sustainable alternatives for industrial processes. Different aldoxime dehydratases accept a broad range of aldoximes with impressive high substrate loadings of up to >1 Kg L−1 and can efficiently catalyze the reaction in aqueous media as well as in non-aqueous systems, such as organic solvents and solvent-free (neat substrates). This paper provides an overview of the recent developments in this field with emphasis on strategies that may be of relevance for industry and sustainability. When possible, potential links to biorefineries and to the use of biogenic raw materials are discussed.

Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction

Science ◽  
2018 ◽  
Vol 360 (6396) ◽  
pp. 1438-1442 ◽  
Author(s):  
Jianfeng Chen ◽  
Xing Gong ◽  
Jianyu Li ◽  
Yingkun Li ◽  
Jiguo Ma ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
High Activity ◽  
Asymmetric Catalysis ◽  
Carbonyl Group ◽  
Mannich Reaction ◽  
Primary Amine ◽  
Chiral Amines ◽  
Carbonyl Groups ◽  
Diphenylphosphinyl Imines

Chiral amines are widely used as catalysts in asymmetric synthesis to activate carbonyl groups for α-functionalization. Carbonyl catalysis reverses that strategy by using a carbonyl group to activate a primary amine. Inspired by biological carbonyl catalysis, which is exemplified by reactions of pyridoxal-dependent enzymes, we developed an N-quaternized pyridoxal catalyst for the asymmetric Mannich reaction of glycinate with aryl N-diphenylphosphinyl imines. The catalyst exhibits high activity and stereoselectivity, likely enabled by enzyme-like cooperative bifunctional activation of the substrates. Our work demonstrates the catalytic utility of the pyridoxal moiety in asymmetric catalysis.

scholarly journals Chiral salen complexes in polymeric main-chains for heterogeneous asymmetric catalysis - a brief account

2020 ◽  
Vol 58 (1) ◽  
pp. 29-39
Author(s):  
Hiba Dandachi ◽  
Xiang Hong ◽  
Farah Ibrahim ◽  
Houssein Nasrallah ◽  
Anaïs Zulauf ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Salen Complexes ◽  
Heterogeneous Asymmetric Catalysis ◽  
Chiral Salen Complexes
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