Cortical Mapping in the Resection of Malignant Cerebral Gliomas

Glioblastoma ◽  
2017 ◽  
pp. 263-280 ◽  
Author(s):  
JEHAD ZAKARIA ◽  
◽  
VIKRAM C. PRABHU ◽  
Keyword(s):  
Cortical Mapping ◽  
Cerebral Gliomas

MANAGEMENT OPTIONS FOR CEREBRAL GLIOMAS

2013 ◽  
Vol 19 (5) ◽  
pp. 1-11
Author(s):  
Wael El-Mesallamy ◽  
Hamdy M. Farahat Farahat ◽  
Tarek Abdel Bary ◽  
Magdy Rashed
Keyword(s):  
Management Options ◽  
Cerebral Gliomas

scholarly journals MS-1 Surgical strategy for brain tumor based on molecular and functional connectomics profiles

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii2-ii2
Author(s):  
Tatsuya Abe
Keyword(s):  
Overall Survival ◽  
Brain Tumor ◽  
Standard Procedure ◽  
Awake Craniotomy ◽  
Surgical Strategy ◽  
Neurological Deficits ◽  
Cortical Mapping ◽  
Photodynamic Diagnosis ◽  
Tumor Surgery ◽  
Brain Tumor Surgery

Abstract It is reported that the development of new perioperative motor deficits was associated with decreased overall survival despite similar extent of resection and adjuvant therapy. The maximum safe resection without any neurological deficits is required to improve overall survival in patients with brain tumor. Surgery is performed with various modalities, such as neuro-monitoring, photodynamic diagnosis, neuro-navigation, awake craniotomy, intraoperative MRI, and so on. Above all, awake craniotomy technique is now the standard procedure to achieve the maximum safe resection in patients with brain tumor. It is well known that before any treatment, gliomas generate globally (and not only focally) altered functional connectomics profiles, with various patterns of neural reorganization allowing different levels of cognitive compensation. Therefore, perioperative cortical mapping and elucidation of functional network, neuroplasticity and reorganization are important for brain tumor surgery. On the other hand, recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. Then, we aimed to identify these biomarkers in pre-operative and/or intra-operative periods, using liquid biopsy, immunostaining and various PCR methods including rapid genotyping assay. In this presentation, we would like to demonstrate our surgical strategy based on molecular and functional connectomics profiles.

L'aumento del segnale di colina coincide con la trasformazione maligna dei gliomi cerebrali: Studio longitidinale con imaging di spettroscopia protonica in risonanza magnetica

1997 ◽  
Vol 10 (2_suppl) ◽  
pp. 18-19
Author(s):  
G. Tedeschi ◽  
N. Lundbom ◽  
R. Raman ◽  
S. Bonavita ◽  
J.H. Duyn ◽  
...  
Keyword(s):  
Proton Magnetic Resonance ◽  
Statistical Significance ◽  
Risonanza Magnetica ◽  
Emission Tomography ◽  
Magnetic Resonance Spectroscopic Imaging ◽  
Malignant Degeneration ◽  
High Grade ◽  
Positron Emission ◽  
Cerebral Gliomas ◽  
High Degree

We tested the hypothesis that proton magnetic resonance spectroscopic imaging (1H-MRSI) can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of either low-to-high grade malignant transformation or of post-therapeutic recurrence. Twenty-seven patients with histologically verified cerebral gliomas were studied repeatedly with 1H-MRSI over a period of 3.5 years. At the time of each 1H-MRSI study, clinical examination, MRI, positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG), and biopsy findings (when available) were used to categorize each patient as being either «stable» or «progressive». Measures of the between-studies percent changes in the choline 1H-MRSI signal intensity, obtained without knowledge of the clinical categorization, segregated the groups with a high degree of statistical significance. All progressive cases showed a between-studies choline signal increase of more than 45%, while all stable cases showed an elevation of less than 35%, no change, or even a decreased signal. We conclude that increased choline coincides with malignant degeneration of cerebral gliomas, and therefore, may possibly be used as a supportive indicator of malignant degeneration of these neoplasms.

Combined Utility of Functional MRI, Cortical Mapping, and Frameless Stereotaxy in the Resection of Lesions in Eloquent Areas of Brain in Children

1997 ◽  
Vol 26 (2) ◽  
pp. 68-82 ◽  
Author(s):  
Simon R. Stapleton ◽  
Elaine Kiriakopoulos ◽  
David Mikulis ◽  
James M. Drake ◽  
Harold J. Hoffman ◽  
...  
Keyword(s):  
Functional Mri ◽  
Cortical Mapping ◽  
Frameless Stereotaxy ◽  
Eloquent Areas

scholarly journals Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas

2006 ◽  
Vol 19 (4) ◽  
pp. 463-475 ◽  
Author(s):  
Isabelle Catalaa ◽  
Roland Henry ◽  
William P. Dillon ◽  
Edward E. Graves ◽  
Tracy R. McKnight ◽  
...  
Keyword(s):  
Newly Diagnosed ◽  
Cerebral Gliomas

Clinical Long-Term Follow-Up Evaluation of Functional Neuronavigation in Adult Cerebral Gliomas

2018 ◽  
Vol 119 ◽  
pp. e262-e271 ◽  
Author(s):  
Shushan Sang ◽  
Siyi Wanggou ◽  
Zaibin Wang ◽  
Xuelei Lin ◽  
Nian Jiang ◽  
...  
Keyword(s):  
Cerebral Gliomas ◽  
Long Term Follow Up ◽  
Functional Neuronavigation

Computer-controlled electrical stimulation for quantitative mapping of human cortical function

2009 ◽  
Vol 110 (6) ◽  
pp. 1300-1303 ◽  
Author(s):  
Mario F. Dulay ◽  
Dona K. Murphey ◽  
Ping Sun ◽  
Yadin B. David ◽  
John H. R. Maunsell ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Detection Threshold ◽  
Electrical Current ◽  
Controlled Delivery ◽  
Cortical Mapping ◽  
Cortical Function ◽  
Quantitative Mapping ◽  
Neurosurgical Patients ◽  
Discrete Area ◽  
Computer Controlled

Cortical mapping with electrical stimulation (ES) in neurosurgical patients typically involves the manually controlled delivery of suprathreshold electrical current to a discrete area of the brain. Limited numbers of trials and imprecise current delivery methods increase the variability of the behavioral response and make it difficult to collect quantitative mapping data, which is especially important in research studies of human cortical function. To overcome these limitations, the authors developed a method for computer-controlled delivery of defined electrical current to implanted intracranial electrodes. They demonstrate that stimulation can be time locked to a behavioral task to rapidly and systematically measure the detection threshold for ES in human visual cortex over many trials. Computer-controlled ES is well suited for the systematic and quantitative study of the function of virtually any region of cerebral cortex. It may be especially useful for studying human cortical regions that are not well characterized and for verifying the presence of stimulation-evoked percepts that are difficult to objectively confirm.

Methodological and Technical Issues for Integrating Functional Magnetic Resonance Imaging Data in a Neuronavigational System

Neurosurgery ◽  
2001 ◽  
Vol 49 (5) ◽  
pp. 1145-1157 ◽  
Author(s):  
Franck-Emmanuel Roux ◽  
Danielle Ibarrola ◽  
Michel Tremoulet ◽  
Yves Lazorthes ◽  
Patrice Henry ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Motor Cortex ◽  
Brain Mapping ◽  
Fmri Data ◽  
Electrode Placement ◽  
Cortical Mapping ◽  
Tumor Surgery ◽  
Motor Cortex Stimulation ◽  
Functional Magnetic Resonance ◽  
Brain Tumor Surgery

ABSTRACT OBJECTIVE The aim of this article was to analyze the technical and methodological issues resulting from the use of functional magnetic resonance image (fMRI) data in a frameless stereotactic device for brain tumor or pain surgery (chronic motor cortex stimulation). METHODS A total of 32 candidates, 26 for brain tumor surgery and six chronic motor cortex stimulation, were studied by fMRI scanning (61 procedures) and intraoperative cortical brain mapping under general anesthesia. The fMRI data obtained were analyzed with the Statistical Parametric Mapping 99 software, with an initial analysis threshold corresponding to P < 0.001. Subsequently, the fMRI data were registered in a frameless stereotactic neuronavigational device and correlated to brain mapping. RESULTS Correspondence between fMRI-activated areas and cortical mapping in primary motor areas was good in 28 patients (87%), although fMRI-activated areas were highly dependent on the choice of paradigms and analysis thresholds. Primary sensory- and secondary motor-activated areas were not correlated to cortical brain mapping. Functional mislocalization as a result of insufficient correction of the echo-planar distortion was identified in four patients (13%). Analysis thresholds (from P < 0.0001 to P < 10−12) more restrictive than the initial threshold (P < 0.001) had to be used in 25 of the 28 patients studied, so that fMRI motor data could be matched to cortical mapping spatial data. These analysis thresholds were not predictable preoperatively. Maximal tumor resection was accomplished in all patients with brain tumors. Chronic motor cortex electrode placement was successful in each patient (significant pain relief >50% on the visual analog pain scale). CONCLUSION In brain tumor surgery, fMRI data are helpful in surgical planning and guiding intraoperative brain mapping. The registration of fMRI data in anatomic slices or in the frameless stereotactic neuronavigational device, however, remained a potential source of functional mislocalization. Electrode placement for chronic motor cortex stimulation is a good indication to use fMRI data registered in a neuronavigational system and could replace somatosensory evoked potentials in detection of the central sulcus.

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