scholarly journals An In Vivo Study of Free Radicals Generated in Murine Skin by Protoporphyrin IX and Visible Light

2006 ◽  
Vol 82 (3) ◽  
pp. 738 ◽  
Author(s):  
Kozo Nakai ◽  
Ann G. Motten ◽  
Colin F. Chignell
Keyword(s):  
Free Radicals ◽  
Visible Light ◽  
Protoporphyrin Ix ◽  
In Vivo Study

Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: In vivo study

2005 ◽  
Vol 36 (3) ◽  
pp. 234-237 ◽  
Author(s):  
Andrea Degen ◽  
Tanja Gabrecht ◽  
Georges Wagnières ◽  
Rosmarie Caduff ◽  
Bruno Imthurn ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
In Vivo Study

scholarly journals Potential Use ofC60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Abdulmalik Altaf ◽  
Hibah Aldawsari ◽  
Zainy M. Banjar ◽  
Daisuke Iohara ◽  
Makoto Anraku ◽  
...  
Keyword(s):  
Visible Light ◽  
Cancer Cells ◽  
Visible Light Irradiation ◽  
Hela Cells ◽  
Protoporphyrin Ix ◽  
A549 Cells ◽  
Light Irradiation ◽  
Dependent Manner ◽  
Irradiation Level

The photosensitizing ability of C60/2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) nanoparticles under visible light irradiation was studied by electron spin resonance (ESR) and phototoxicity on cancer cells. In addition, the photoinduced antitumor effect to the tumor-bearing mice was evaluated. C60nanoparticles were prepared by grinding a mixture of HP-β-CyD. The resulting C60/HP-β-CyD nanoparticles were highly-sensitive to visible light and generated higher levels of1O2than protoporphyrin IX (PpIX). C60/HP-β-CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner. The IC50values of the C60/HP-β-CyD nanoparticles was 10 μM for HeLa cells and 60 μM for A549 cells at an irradiation level of 35 mW/cm2. The photodynamic effect of C60/HP-β-CyD nanoparticles on thein vivogrowth of mouse sarcoma S-180 cells was evaluated after intratumor injection. The outcome of PDT by C60/HP-β-CyD was directly dependent on the dose of irradiated light. Treatment with C60/HP-β-CyD nanoparticles at a C60dose of 2.0 mg/kg under visible light irradiation at 350 mW/cm2(63 J/cm2) markedly suppressed tumor growth, whereas that at 30 J/cm2was less effective. These findings suggest that C60/HP-β-CyD nanoparticles represent a promising candidate for use in cancer treatment by PDT.

A temporal survey on protoporphyrin IX fluorescence signal after administration of 5ALA conjugated gold nanoparticles: An in vivo study on CT26 tumors

2011 ◽  
Vol 44 (13) ◽  
pp. S217-S218
Author(s):  
Nafiseh Sobhani ◽  
Ameneh Sazgarnia ◽  
Nadia Naghavi ◽  
Omid Rajabi ◽  
Saeed Akhlaghi
Keyword(s):  
Gold Nanoparticles ◽  
Protoporphyrin Ix ◽  
In Vivo Study ◽  
Fluorescence Signal

scholarly journals Protective effect of Acampe praemorsa (Roxb.) Blatt. & McCann against oxidative stress

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
U Praveen Kumar ◽  
GSN Koteswara Rao ◽  
A Rajasekhar Reddy ◽  
K Umasankar ◽  
Y Vangoori
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Reducing Power ◽  
The Body ◽  
In Vivo Study ◽  
Oxidative Enzymes ◽  
Hydroalcoholic Extract ◽  
Study Results

The current study was carried to make available phytochemical information and evaluation of antioxidant activity of Acampe praemorsa (Roxb.) Blatt. & McCann. The phytochemical analysis was carried out using procedures and quantified phenolic and alkaloid contents. The antioxidant activity was evaluated by in-vitro and in-vivo studies. The In-vitro antioxidant activity was carried on free radicals such as superoxide, hydroxyl DPPH, hydrogen peroxide, evaluation of reducing power. In-vivo study was carried on albino Wistar rats with different doses of extracts. The results provide that, A. praemorsa extracts have diversified phytochemicals in extracts like steroids, alkaloids, phenolics, glycosides, oils, quinones, tannins etc. The hydroalcoholic extract has more phenolic (26.80±0.51) and alkaloid (20.59±0.22) contents. The antioxidant activity results provide information that the extracts possess concentration dependent activity on tested free radicals. The hydroalcoholic extract has more protective nature against superoxide, DPPH, H2O2 free radicals and reducing power but ethyl acetate extract has more potential against hydroxyl free radical than hydroalcoholic extract. The extracts were found to be safe on toxic studies and In-vivo study results and they play significant role in controlling the oxidative enzymes such as catalase, superoxide dismutase, lipid peroxidation (malonaldehyde) in the body. Thus, it was determined that A. praemorsa have potential bioactive compounds and antioxidant activity.

Time-lag combination therapy for cerebral ischemia using the FNK protein transduction technology and an immunosuppressant, I: In vivo study

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S57-S57
Author(s):  
Ken-ichiro Kasura ◽  
Megumi Watanabe ◽  
Kumiko Takahashi ◽  
Genki Mizukoshi ◽  
Seiji Ohkubo ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Combination Therapy ◽  
Time Lag ◽  
In Vivo Study ◽  
Protein Transduction
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