INTRACELLULAR TARGETS OF PROAPOPTOTIC INFLUENCE OF GASEOUS TRANSMITTERS
2012 ◽
Vol 67
(10)
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pp. 77-81
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Main molecular targets of nitric oxide, hydrogen sulfide and carbon monoxide proapoptotic action in Jurkat cells were determined in this study. Decrease of mitochondrial transmembrane potential was shown during all three gases action. Reason of this event is the Bcl-2 family members disbalance. Proapoptotic proteins release after mitochondrion membranes permeabilisation could be abolished by protein xIAP inhibition of caspase -9 and-3 activity during NO and CO application.
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2018 ◽
Vol 17
(9)
◽
pp. 654-670
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Keyword(s):
2018 ◽
Vol 46
(5)
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pp. 1107-1118
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Keyword(s):
2016 ◽
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