Asthma Activity and Respiratory Morbidity in Children during the COVID-19 Pandemic: Results of a Retrospective Comparative Observational Study

Background. According to available studies during the pandemic, the incidence of COVID-19 among children was significantly lower than among adults. However, it remains unclear whether children with allergies and asthma are at risk for COVID-19 and whether the respiratory morbidity have changed during the pandemic in children with asthma as well as the asthma activity. Aims to determine the respiratory morbidity in children with and without asthma before and during the COVID-19 pandemic, to estimate asthma activity. Methods. The main group was formed of 60 children 617 y.o with confirmed asthma diagnosis, the control group from 30 children aged 617 y.o. without asthma. Data on outcomes in children with asthma and in control group were obtained on the basis of the retrospective collected information from medical records of patients and from questionnaires, filled during telephone call in 2020. Respiratory morbidity was estimated in 2019 and during the COVID-19 pandemic period in 2020 till the end of May. Results. The incidence of upper respiratory tract infections has decreased in 2020 in 72% of children with asthma by an average of 53%; in 86% of children without by an average of 62%. The frequency of lower respiratory tract infections decreased in 37% of children with asthma by an average of 61%, in 20% of children without asthma on 100%. According to the patients parents answers, none of the children were diagnosed with COVID-19. The number of episodes which required additional anti-asthma therapy decreased or didnt change in 77% of patients. According to the results of the Asthma Control Test in 2020 asthma was fully controlled in 82% of patients, 65% of patients had complete adherence to therapy. Conclusions. Children with asthma and allergies, as well as healthy children, do not seem to be at risk of contracting a new coronavirus infection. Lockdown, good adherence to therapy in children with asthma had a positive impact, led to a decrease of respiratory morbidity, exacerbations of asthma, improved disease control. Further monitoring of children with allergies and asthma during the COVID-19 pandemic is required.

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A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-aro-809 ◽

2020 ◽

Vol 10 (2) ◽

pp. 359-367

Author(s):

I. I. Ababii ◽

L. A. Danilov ◽

M. K. Maniuc ◽

P. I. Ababii ◽

S. S. Ghinda ◽

...

Keyword(s):

Respiratory Tract ◽

Respiratory Tract Infections ◽

Chronic Tonsillitis ◽

Upper Respiratory Tract Infections ◽

Control Group ◽

Healthy Children ◽

Upper Respiratory Tract ◽

Upper Respiratory ◽

Tract Infections

Currently, a rise in incidence of polyethological inflammation of the upper respiratory tract mucosa paralleled by altered resident and transient microbiota displaying in many cases increased antibiotic resistance has been noted. Opportunistic microbes play a major role in developing inflammatory process in Pirogov–Waldeyer’s ring. An inflammatory process occurring in the tonsillar lymphatic tissue results in host systemic complications. Fighting against acute and chronic infections of the upper respiratory tract holds the main task in pediatric otorhinolaryngology, as they can consequently elicit the cardiovascular, genitourinary and musculoskeletal complications. The results of studies examining this issue remain very contradictory, which accounted for a need to conduct our study on the territory of Moldova featured with mixed climatic conditions. Here, we wanted to study a role of microbial factor in etiopathogenesis of chronic tonsillitis in children. Bacteriological microbiota data for superficial palatine tonsils were obtained form 608 children subdivided into 5 groups: group I — 333 children with compensated chronic tonsillitis; group II — 87 children with decompensated chronic tonsillitis; group III — 91 children with acute upper respiratory tract infections (comparison group); group IV — 48 children with acute upper respiratory tract infections treated with antibiotic therapy; group V — 49 apparently healthy children (control group). It was found that β-hemolytic streptococcus exerting high sensitivity to virtually all antibiotics groups was detected in 17.4% of children with acute tonsilar inflammatory processes and decompensated defense in the lymphatic pharyngeal ring compared to 3.5% in control group. Streptococcus pneumoniae was isolated in all study groups ranging within 4.8–21.7%, including 14% in apparently healthy children characterized by reduced antibiotics sensitivity. The data obtained suggest that sickly children with acute and chronic upper respiratory tract infections constitute a risk group for developing somatic diseases. The high incidence of Streptococcus pneumoniae indicates a need for performing immunoprophylaxis, use of therapeutic vaccination as a up-to-date, combined approach in treatment of such pediatric cohort.

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v2 ◽

2019 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Primary Immunodeficiency ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 300 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 207 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with primary immunodeficiency (PID) and children with recurrent respiratory tract infections (RRTI) by assessment of their height and weight. All of parameters were evaluated using centile charts suitable best for the Polish population. Results The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 20% of them had their height situated below 3rd percentile. No statistically relevant differences have been found between them and RRTI group. The statistically significant difference was between the nutritional status of PID patients and the control group. Conclusions There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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Estimation of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v1 ◽

2019 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Primary Immunodeficiency ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v7 ◽

2020 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Nutritional Status ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background: Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 350 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 195 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics Ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts, suitable best for the Polish population. Results: The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 18% of them had their height situated below 3rd percentile. The statistically relevant differences have been found between them and RRTI group in terms of weight, height and nutritional status. The statistically significant difference was detected between the nutritional status of PID and control group. Conclusions: There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v5 ◽

2019 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Medical Histories ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 300 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 207 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts suitable best for the Polish population. Results The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 20% of them had their height situated below 3rd percentile. No statistically relevant differences have been found between them and RRTI group. The statistically significant difference was between the nutritional status of PID patients and the control group. Conclusions There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v3 ◽

2019 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Medical Histories ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 300 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 207 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts suitable best for the Polish population. Results The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 20% of them had their height situated below 3rd percentile. No statistically relevant differences have been found between them and RRTI group. The statistically significant difference was between the nutritional status of PID patients and the control group. Conclusions There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v4 ◽

2019 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Medical Histories ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 300 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 207 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts suitable best for the Polish population. Results The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 20% of them had their height situated below 3rd percentile. No statistically relevant differences have been found between them and RRTI group. The statistically significant difference was between the nutritional status of PID patients and the control group. Conclusions There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections.

10.21203/rs.2.10386/v6 ◽

2020 ◽

Author(s):

Karolina Pieniawska-Śmiech ◽

Kamil Bar ◽

Mateusz Babicki ◽

Karol Śmiech ◽

Aleksandra Lewandowicz-Uszyńska

Keyword(s):

Birth Weight ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Physical Growth ◽

Control Group ◽

Healthy Children ◽

Significant Difference ◽

Medical Histories ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Background Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 300 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn't present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 207 patients' medical histories from their hospitalization at Clinical Immunology and Paediatrics ward of J.Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts suitable best for the Polish population. Results The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 20% of them had their height situated below 3rd percentile. No statistically relevant differences have been found between them and RRTI group. The statistically significant difference was between the nutritional status of PID patients and the control group. Conclusions There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

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