scholarly journals GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Cell Stress ◽  
2021 ◽  
Vol 5 (11) ◽  
pp. 173-175
Author(s):  
Constantinos Demetriades ◽  
Julian Nüchel ◽  
Markus Plomann
Keyword(s):  
Growth Factor ◽  
Human Disease ◽  
Low Energy ◽  
Biological Research ◽  
Stress Signaling ◽  
Adaptation To Stress ◽  
Cellular Adaptation ◽  
Homeostatic Process ◽  
Extracellular Proteome ◽  
Growth Factor Deprivation

Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.

scholarly journals Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress

Contact ◽  
2021 ◽  
Vol 4 ◽  
pp. 251525642110166
Author(s):  
Verena Kohler ◽  
Sabrina Büttner
Keyword(s):  
Nuclear Envelope ◽  
Internal Stress ◽  
Molecular Architecture ◽  
Adaptation To Stress ◽  
Semipermeable Membranes ◽  
Cellular Adaptation ◽  
Membrane Contact Sites ◽  
Contact Sites ◽  
Intracellular Compartments ◽  
Membrane Contact

Cellular adaptation to stress and metabolic cues requires a coordinated response of different intracellular compartments, separated by semipermeable membranes. One way to facilitate interorganellar communication is via membrane contact sites, physical bridges between opposing organellar membranes formed by an array of tethering machineries. These contact sites are highly dynamic and establish an interconnected organellar network able to quickly respond to external and internal stress by changing size, abundance and molecular architecture. Here, we discuss recent work on nucleus-vacuole junctions, connecting yeast vacuoles with the nucleus. Appearing as small, single foci in mitotic cells, these contacts expand into one enlarged patch upon nutrient exhaustion and entry into quiescence or can be shaped into multiple large foci essential to sustain viability upon proteostatic stress at the nuclear envelope. We highlight the remarkable plasticity and rapid remodelling of these contact sites upon metabolic or proteostatic stress and their emerging importance for cellular fitness.

scholarly journals RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

2018 ◽  
Vol 9 ◽  
Author(s):  
Vishnu Hosur ◽  
Michelle L. Farley ◽  
Benjamin E. Low ◽  
Lisa M. Burzenski ◽  
Leonard D. Shultz ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Growth Factor ◽  
Human Disease ◽  
Growth Factor Signaling ◽  
Murine Models

scholarly journals Control of mRNA Splicing by Intragenic RNA Activators of Stress Signaling: Potential Implications for Human Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Raymond Kaempfer ◽  
Lena Ilan ◽  
Smadar Cohen-Chalamish ◽  
Orli Turgeman ◽  
Lise Sarah Namer ◽  
...  
Keyword(s):  
Human Disease ◽  
Mrna Splicing ◽  
Stress Signaling

DNA polymerase κ: Friend or foe?

2020 ◽  
Vol 13 (629) ◽  
pp. eabb2934
Author(s):  
Joann B. Sweasy
Keyword(s):  
Dna Polymerase ◽  
Melanoma Cells ◽  
Adaptation To Stress ◽  
Cellular Adaptation ◽  
Targeted Inhibitors ◽  
Translesion Dna

In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

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