scholarly journals Prevalence of serum antibodies against vaccine-preventable diseases in Japanese students and its advisory standard of vaccination

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Kei Numazaki
1996 ◽  
Vol 76 (06) ◽  
pp. 1020-1029 ◽  
Author(s):  
Laurent Macchi ◽  
Gisèle Clofent-Sanchez ◽  
Gérald Marit ◽  
Claude Bihour ◽  
Catherine Durrieu-Jais ◽  
...  

SummaryIn idiopathic thrombocytopenic purpura (ITP), autoantibodies reacting with antigens on the platelet membrane bring about accelerated platelet destruction. We now report PAICA (“Platelet-Associated IgG Characterization Assay”), a method for detecting autoantibodies bound to specific membrane glycoproteins in total platelet lysates. This monoclonal antibody (MAb) capture assay takes into account the fact that antibodies on circulating platelets may be translocated to internal pools as well as being on the surface. A total of twenty ITP patients were examined by PAICA, and the results compared with those obtained by measuring (i) serum antibodies bound to paraformaldehyde-fixed control platelets by ELISA, (ii) IgG bound to the surface of the patient’s own platelets by flow cytometry (PSIgG), (iii) total platelet-associated IgG (PAIgG) by ELISA and (iv) serum antibodies reacting with control platelets by MAIPA (“Monoclonal Antibody-specific Immobilization of Platelet Antigens”). Of twelve patients with elevated PAIgG, nine had increased PSIgG yet eleven reacted positively in PAICA. Of these, eight possessed antibodies directed against GP Ilb-IIIa, two against GP Ib-IX and one patient possessed antibodies directed against GP Ilb-IIIa and GP Ia-IIa respectively. Only seven of the patients possessed serum antibodies detectable by MAIPA. PAICA was also able to detect platelet-associated c7E3 (the chimeric form of Fab fragments of the MAb 7E3) following its infusion during antithrombotic therapy, when it proved more sensitive over a seven-day period than a MAIPA assay adapted for assessing surface-bound antibody. We propose that PAICA provides added sensitivity to the detection of platelet-associated antibodies in immune thrombocytopenias or following therapy with humanized MAbs.


2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Dr. Rakesh Chandra ◽  
Mr. Pravesh Dwivedi ◽  
Dr. Ritesh Dwivedi

Universal immunization of children against common vaccine preventable diseases is the most important aspect of childcare programs. It has long been a goal of the Universal Immunization Program. National Population Policy, 2000 has also stressed on development of Indian Immunization Program, as India is one of the largest in the world, in terms of quantities of vaccines used, numbers of beneficiaries, and the numbers of immunization sessions organized. This program is spread all across the country and seven vaccines are used to protect children and pregnant mothers against tuberculosis, diphtheria, pertusis, polio, measles tetanus and hepatitis-B. Some other supplements like vitamin A and iron tablets have also been added with this delivery mechanism to support overall nutritional level of children and their mothers. To assess the grassroot level condition, this study has tried to explore and compare the different parameters related to routine vaccination and supplement distribution in some selected districts. Role of ASHAs and ANMs is very important for this whole immunization program and to enhance the coverage in qualitative manner, certain evaluation parameters must be established like how many households are aware of sanitation, hygiene, preventive health and healthy lifestyle through ASHA and ANM work.


1997 ◽  
Vol 17 (3) ◽  
pp. 536-541 ◽  
Author(s):  
Bernhard Metzler ◽  
Georg Schett ◽  
Roman Kleindienst ◽  
Ruurd van der Zee ◽  
Tom Ottenhoff ◽  
...  

2019 ◽  
Vol 11 (5) ◽  
pp. 331-333 ◽  
Author(s):  
Peter J Hotez

Abstract Over the last decade we have seen extraordinary public health gains due to expansions in global vaccination programs led by United Nations (UN) agencies, including Gavi, the Vaccine Alliance, UNICEF and the WHO. These initiatives have reduced childhood deaths from measles, tetanus and other vaccine-preventable diseases by almost one half. There is additional excitement over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, conflict and an accelerating antivaccine movement. New initiatives in vaccine diplomacy will be required to combat these challenges.


1991 ◽  
Vol 35 (3) ◽  
pp. 174-179 ◽  
Author(s):  
Esther Levy ◽  
Miriam Margalith ◽  
Batia Sarov ◽  
Israel Sarov ◽  
Charles R. Rinaldo ◽  
...  

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