Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus

Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.

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Simultaneously acute hepatitis B virus and C virus coinfection and subsequent chronic hepatitis C

Scandinavian Journal of Infectious Diseases ◽

10.1080/00365540600951358 ◽

2007 ◽

Vol 39 (4) ◽

pp. 351-354 ◽

Cited By ~ 5

Author(s):

Shuo-Wei Chen ◽

Tsung-Shih Lee ◽

Ching-Chih Hu ◽

Liang-Che Chang ◽

Rong-Nan Chien

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Acute Hepatitis ◽

Chronic Hepatitis C ◽

B Virus ◽

Acute Hepatitis B

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Membranous Nephropathy Associated with Chronic Hepatitis B Occurring in a Short Period After Acute Hepatitis B Virus Infection

Internal Medicine ◽

10.2169/internalmedicine.49.2812 ◽

2010 ◽

Vol 49 (5) ◽

pp. 383-388 ◽

Cited By ~ 7

Author(s):

Kazunari Nakahara ◽

Hideaki Takahashi ◽

Chiaki Okuse ◽

Ryuta Shigefuku ◽

Norie Yamada ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Acute Hepatitis ◽

Membranous Nephropathy ◽

Hepatitis B Virus Infection ◽

Short Period ◽

B Virus ◽

Acute Hepatitis B

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Acute hepatitis B virus infection or acute exacerbation of chronic hepatitis B infection: the differential serological diagnosis

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s10096-015-2522-7 ◽

2015 ◽

Vol 35 (1) ◽

pp. 29-40 ◽

Cited By ~ 7

Author(s):

R. A. A. Pondé

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Acute Hepatitis ◽

Hepatitis B Virus Infection ◽

Hepatitis B Infection ◽

Chronic Hepatitis B Infection ◽

B Virus ◽

Acute Hepatitis B

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Results of implementation of viral hepatitis B elimination program in the North-West Russia

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-rot-1785 ◽

2021 ◽

Vol 11 (5) ◽

pp. 875-886

Author(s):

L. V. Lyalina ◽

E. V. Esaulenko ◽

E. V. Khorkova ◽

K. E. Novak ◽

Y. V. Ostankova ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Acute Hepatitis ◽

Incidence Rate ◽

Chronic Hepatitis B ◽

North West ◽

The North ◽

B Virus ◽

Acute Hepatitis B

Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.

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