The aim of the present study was to examine potential protective effects of
methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a
rat model of acute intoxication with carbon tetrachloride (CCl4) by tracking
the changes in liver morphology and function. Serum transaminase and
bilirubin were significantly elevated in animals treated with CCl4 alone. A
pretreatment with M and I prior to the administration of CCl4 significantly
prevented the increase of serum levels of liver damage markers.
Histopathological evaluation of the livers of the test animals also revealed
that M and I reduced the incidence of liver lesions. Our experiments showed
that both M and I possess protective effect in CCl4-induced liver damage in
rats. The results are of interest due to the presence of natural or synthetic
M in the human diet.
Influence of methyl and isopropyl N-methyl antranilates on carbon tetrachloride-induced changes in rat liver morphology and function