scholarly journals Influence of methyl and isopropyl N-methyl antranilates on carbon tetrachloride-induced changes in rat liver morphology and function

2013 ◽  
Vol 11 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Niko Radulovic ◽  
Pavle Randjelovic ◽  
Nikola Stojanovic ◽  
Ivan Ilic ◽  
Ana Miltojevic
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Serum Levels ◽  
Protective Effects ◽  
Liver Lesions ◽  
Human Diet ◽  
Histopathological Evaluation ◽  
Liver Morphology ◽  
And Function ◽  
Induced Changes

The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl4) by tracking the changes in liver morphology and function. Serum transaminase and bilirubin were significantly elevated in animals treated with CCl4 alone. A pretreatment with M and I prior to the administration of CCl4 significantly prevented the increase of serum levels of liver damage markers. Histopathological evaluation of the livers of the test animals also revealed that M and I reduced the incidence of liver lesions. Our experiments showed that both M and I possess protective effect in CCl4-induced liver damage in rats. The results are of interest due to the presence of natural or synthetic M in the human diet.

Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats

1999 ◽  
Vol 17 (4) ◽  
pp. 253-259 ◽  
Author(s):  
Mustafa Naziroğlu ◽  
Mehmet Çay ◽  
Bilal Üstündağ ◽  
Mesut Aksakal ◽  
Hayrettin Yekeler
Keyword(s):  
Vitamin E ◽  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Protective Effects

Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice

2017 ◽  
Vol 72 ◽  
pp. 42-50 ◽  
Author(s):  
Yifei Yang ◽  
Lingyun Yang ◽  
Yaodan Han ◽  
Zhenwei Wu ◽  
Pan Chen ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Protective Effects

Ameliorative effect of trimetazidine on cisplatin-induced hepatotoxicity in rats

2016 ◽  
Vol 94 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Hayam Ateyya ◽  
Hala Yosef ◽  
Manar A. Nader
Keyword(s):  
Liver Damage ◽  
Antioxidant Defense System ◽  
Serum Levels ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Protective Effects ◽  
Bax Protein ◽  
Ameliorative Effect ◽  
Glutamyl Transferase ◽  
Per Oral

This study was designed to evaluate the protective effects of trimetazidine (TMZ) against cisplatin (CP) induced liver damage in rats. Animals were distributed among 4 groups as follows: control group; TMZ group (20 mg/kg body mass, per oral), which was treated for 10 days; CP group (6 mg/kg, by intraperitoneal injection), which received a single injection; and the CP + TMZ group (20 mg/kg, per oral), which received TMZ 4 days before and 6 days after CP injection. The extent of hepatic damage was studied by assessing biochemical parameters and histopathological evaluation of the extracted liver tissue. The results revealed that liver enzymes were markedly elevated after injection of CP, as evident from significant increases in the serum levels of alanine transaminase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (γ-GT), and lactate dehydrogenase (LDH), as well as marked changes to the liver architecture, with a significant decrease in serum levels of albumin. There were also marked changes to the antioxidant defense system, as indicated by significant decreases in total antioxidants and hepatic levels of reduced glutathione (GSH) and superoxide dismutase (SOD), together with a significant increase in lipid peroxidation. However, there was a significant increase in the activity of hepatic nuclear factor kappa B (NF-κB) as well as hepatic Bax protein expression. We conclude that TMZ protects against CP-induced liver damage through scavenging free radicals and anti-inflammatory and antiapoptotic effects, as well as through reducing NF-κB activation.

scholarly journals Salvia miltiorrhizaInjection Ameliorates Renal Damage Induced by Lead Exposure in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Lei Li ◽  
Yuanyuan Zhang ◽  
Juanjuan Ma ◽  
Weichong Dong ◽  
Qiongtao Song ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Salvia Miltiorrhiza ◽  
Kidney Injury ◽  
Serum Levels ◽  
Organ Injury ◽  
Therapeutic Drug ◽  
High Dose ◽  
Protective Effects ◽  
Pb Accumulation ◽  
And Function

Exposure to lead (Pb) can induce kidney injury and our recent studies have found thatSalvia miltiorrhiza(SM) injection, a traditional Chinese medicine, could protect against the organ injury induced by iron overload. This study was designed to investigate the protective effects of SM injection on nephrotoxicity induced by Pb acetate in mice and to elucidate the potential mechanism(s). Healthy male mice were randomly divided into four groups: control, Pb, low-doseSalvia miltiorrhiza(L-SM), and high-doseSalvia miltiorrhiza(H-SM). SM injection dose dependently reduced the Pb accumulation in the kidney, decreased kidney coefficients, and ameliorated renal structure and function from the morphology analysis. Meanwhile, SM administration downregulated serum levels of blood urea nitrogen (BUN) and creatinine (CR), decreased malondialdehyde (MAD) content, and increased activities of super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the kidney homogenate. Moreover, SM injection reduced the level of renal apoptosis by immunohistochemical staining analysis. Our findings implicate the therapeutic potential of SM injection for Pb-induced nephrotoxicity, which were at least partly due to the decrease of Pb accumulation, inhibition of lipid peroxidation, and suppression of renal apoptosis. These results provided preliminary experimental support for Danshen as a therapeutic drug for Pb poisoning diseases.

scholarly journals Hepatoprotective Effect of Tagetes Erecta L. Extract on Carbon Tetrachloride Induced Hepatotoxicity in Rats

2019 ◽  
Vol 9 (4-s) ◽  
pp. 269-272
Author(s):  
Kamshetti Manoj Vidyadhar ◽  
Hemant Kumar Sharma
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Water Extract ◽  
Free Radical Scavenger ◽  
Hepatoprotective Effect ◽  
Detoxification Enzymes ◽  
Radical Scavenger ◽  
Tagetes Erecta ◽  
Protective Effects ◽  
Tagetes Erecta L

Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. In this study, the protective effects of water extract of Tagetes erecta L. against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that Tagetes erecta L. Extract could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Keywords: Tagetes erecta L., Carbon Tetrachloride, Liver Damage, Hepato-protection

scholarly journals Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL

2021 ◽  
Vol 22 (2) ◽  
pp. 719
Author(s):  
Irene Schilcher ◽  
Julia T. Stadler ◽  
Margarete Lechleitner ◽  
Andelko Hrzenjak ◽  
Andrea Berghold ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Serum Levels ◽  
Paraoxonase 1 ◽  
Endothelial Lipase ◽  
And Function ◽  
Induced Changes ◽  
The Impact ◽  
Mediated Reduction

Endothelial lipase (EL) is a strong modulator of the high-density lipoprotein (HDL) structure, composition, and function. Here, we examined the impact of EL on HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity in vitro and in vivo. The incubation of HDL with EL-overexpressing HepG2 cells decreased HDL size, PON1 content, and AE activity. The EL modification of HDL did not diminish the capacity of HDL to associate with PON1 when EL-modified HDL was incubated with PON1-overexpressing cells. The overexpression of EL in mice significantly decreased HDL serum levels but unexpectedly increased HDL PON1 content and HDL AE activity. Enzymatically inactive EL had no effect on the PON1 content of HDL in mice. In healthy subjects, EL serum levels were not significantly correlated with HDL levels. However, HDL PON1 content was positively associated with EL serum levels. The EL-induced changes in the HDL-lipid composition were not linked to the HDL PON1 content. We conclude that primarily, the interaction of enzymatically active EL with HDL, rather than EL-induced alterations in HDL size and composition, causes PON1 displacement from HDL in vitro. In vivo, the EL-mediated reduction of HDL serum levels and the consequently increased PON1-to-HDL ratio in serum increase HDL PON1 content and AE activity in mice. In humans, additional mechanisms appear to underlie the association of EL serum levels and HDL PON1 content.

scholarly journals Effects of ethanol on intraovarian nitric oxide production in the prepubertal rat

1999 ◽  
Vol 161 (1) ◽  
pp. 69-75 ◽  
Author(s):  
VK Srivastava ◽  
JK Hiney ◽  
V Rettori ◽  
WL Dees
Keyword(s):  
Nitric Oxide ◽  
Ovarian Development ◽  
Ovarian Function ◽  
Serum Levels ◽  
Female Rats ◽  
Nitrite Accumulation ◽  
Stage Of Development ◽  
Male And Female Rats ◽  
And Function ◽  
Induced Changes

Nitric oxide (NO) has been shown to contribute to ovarian development and function. In non-ovarian tissues NO can be altered by ethanol (ETOH), a drug considered to be a gonadal toxin in men as well as male and female rats. The present study was undertaken to determine if some of the detrimental effects of chronic ETOH exposure on prepubertal ovarian function could be due to ETOH-induced alterations in the intraovarian NO system. Rats were implanted with intragastric cannulae on day 24 and began receiving control or ETOH diets on day 29. All rats were killed on day 34, determined to be in the late juvenile stage of development, and their ovaries and blood were collected. We analyzed the expression of the two constitutive forms of nitric oxide synthase (NOS), i.e. neuronal (n) NOS and endothelial (e) NOS, as well as the inducible (i) form of NOS protein in the ovaries of control and ETOH-treated rats by Western immunoblotting. Results demonstrate that eNOS protein increased markedly (P<0.02; 140 kDa) in ETOH-treated rats compared with controls. ETOH treatment did not alter the protein expression of nNOS (155 kDa) and only slightly increased that of iNOS (130 kDa). We also assessed NOS activity as determined by nitrite accumulation and by the conversion of L-[14C]arginine to L-[14C]citrulline. In this regard, the ETOH-treated animals showed an increase in ovarian nitrite generation (P<0.05), as well as an increase in ovarian citrulline formation (P<0.0001), when compared with control animals. Along with the above described ETOH-induced increases in ovarian eNOS and NO activity, the serum levels of estradiol were concomitantly suppressed (P<0.001) in the ETOH-treated rats. These results demonstrate for the first time the ETOH-induced changes in the prepubertal ovarian NO/NOS system, and suggest that these alterations contribute to the detrimental actions of the drug on prepubertal ovarian development and function.

scholarly journals Protective effects of prebiotic (resistant maltodextrin) and silymarin against toxicity of carbon tetrachloride in liver rat and kidney

2020 ◽  
Vol 8 (1) ◽  
pp. 15
Author(s):  
M. G. A. EL. SAYED ◽  
ENAS. A. H. FARAG ◽  
HEBA. M. Nasr
Keyword(s):  
Carbon Tetrachloride ◽  
Serum Levels ◽  
Protective Role ◽  
Vehicle Group ◽  
Albino Rats ◽  
Protective Effects ◽  
Liver And Kidney ◽  
Resistant Maltodextrin ◽  
Hepatic Injuries

Exposure to carbon tetrachloride induces acute and chronic hepatic injuries as well as renal injuries in rats. Therefore, the current study aimed to evaluate the protective role of prebiotic (digestion resistant maltodextrin) and silymarin against carbon tetrachloride -induced heptorenal toxicity in albino rats. Six groups with ten rats each were used for this purpose; these groups included the control vehicle group that received saline daily for 30 days, prebiotic group (1g/kg, orally) daily for 30 days; silymarin group (200 mg/kg orally) daily for 30 days; carbon tetrachloride group (2.5ml/kg intraperitoneally twice per week for three week; the prebiotic – carbon tetrachloride group; the silymarin – carbon tetrachloride group. The results revealed that carbon tetrachloride significantly increased serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin cholesterol, triglyceride, urea and creatinine. In addition, there were substantial increase in lipid peroxidation (malondialdehyde) and level of glucose with significant decreases in albumin, total protein, creatinine kinase, hemoglobin and red blood cells. Carbon tetrachloride also caused histological changes in liver and kidney tissues. However, administration of prebiotic and silymarin alone ameliorated the carbon tetrachloride induced liver and kidney damage with improved hematological, lipid profile and glucose level.  

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