scholarly journals Coagulation status in patients with pulmonary embolism receiving long-term anticoagulant therapy

2022 ◽  
Vol 20 (8) ◽  
pp. 3093
Author(s):  
E. A. Shmidt ◽  
S. A. Berns ◽  
T. Yu. Penskaya ◽  
I. I. Zhidkova ◽  
O. V. Gruzdeva ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Blood Coagulation ◽  
Anticoagulant Therapy ◽  
Thrombin Generation ◽  
Fibrin Clot ◽  
Coagulation Rate ◽  
Integral Methods ◽  
Coagulation Status ◽  
Generation Test

Aim. To study the blood coagulation status by various laboratory methods in patients after pulmonary embolism (PE) receiving long-term anticoagulant therapy.Material and methods. The blood of 23 patients with pulmonary embolism, who received long-term anticoagulant therapy, was studied. The study of coagulation profile, D-dimer, thrombodynamics, thromboelastography and thrombin generation test were carried out.Results. The thrombin generation test shows a significant increase in the time of its formation, while the maximum amount of thrombin formed is half that of the reference values. There is a slightly increased median fibrin clot growth rate in the thrombodynamics test — 30,4 gm/min with a normal coagulation rate of 20-29 gm/min. The result of thromboelastography also reflects the blood hypocoagulation, in terms of R, Angle a and CI.Conclusion. Integral methods for assessing the thrombotic readiness in combination with a routine coagulation panel demonstrate a complete picture of blood coagulation potential in patients after pulmonary embolism requiring long-term anticoagulant therapy.

Factors Associated with Pulmonary Embolism Recurrence and the Benefits of Long-term Anticoagulant Therapy

2018 ◽  
Vol 17 (3) ◽  
pp. 205-211
Author(s):  
Francisco J.A. Sanchez ◽  
Jose L.A. Martínez ◽  
Mirem A.U. Echezarreta ◽  
Ione V. Garcia ◽  
Jorge R. Alvaro
Keyword(s):  
Pulmonary Embolism ◽  
Anticoagulant Therapy ◽  
Factors Associated

Long-term Anticoagulant Therapy for Idiopathic Pulmonary Embolism in the Elderly

CHEST Journal ◽  
2009 ◽  
Vol 135 (5) ◽  
pp. 1243-1251 ◽  
Author(s):  
Jeffrey Haspel ◽  
Kenneth Bauer ◽  
Alexander Goehler ◽  
David H. Roberts
Keyword(s):  
Pulmonary Embolism ◽  
Anticoagulant Therapy ◽  
The Elderly

Thrombin generation test in patients under anticoagulant therapy with vitamin k antagonists

2009 ◽  
Vol 101 (03) ◽  
pp. 594-595 ◽  
Author(s):  
Isabel Brocal ◽  
Javier Lucas ◽  
José Verdú ◽  
Fabián Tarín ◽  
Pascual Marco
Keyword(s):  
Anticoagulant Therapy ◽  
Vitamin K ◽  
Thrombin Generation ◽  
Vitamin K Antagonists ◽  
Generation Test

Evaluation of the hemostatic potential at coronary artery bypass surgery during long-term aspirin therapy

2016 ◽  
Vol 88 (12) ◽  
pp. 21-27
Author(s):  
O V Gruzdeva ◽  
E V Fanaskova ◽  
O E Akbasheva ◽  
E G Uchasova ◽  
T Yu Penskaya ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Platelet Transfusion ◽  
Thrombin Generation ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Term Therapy ◽  
Generation Test

Aim. To estimate thrombin generation test parameters in patients with coronary heart disease during coronary artery bypass surgery under extracorporeal circulation after transfusion of donor platelet concentrates during long-term therapy with acetylsalicylic acid (ASA). Subjects and methods. A total of 148 patients with coronary heart disease who had undergone elective primary coronary artery bypass surgery under extracorporeal circulation during preserved therapy with ASA (75-100 mg/day) were examined. According to donor platelet concentrate transfusion, all the patients were divided into 2 groups: 1) 76 patients undergoing donor platelet transfusion and 2) 72 without this procedure. A control group consisted of 20 apparently healthy individuals. At the pre-, intra-, and early postoperative stages, the investigators evaluated the following thrombin generation test parameters: lag time (min); peak thrombin concentration (nM/l); time to peak (min); the area under the thrombin generation curve (nM), and thrombin generation rate (nM/min). Results. During long-term ASA therapy, the patients were found to have an activated endogenous thrombin potential in the pre- and intraoperative periods, as evidenced by the high peak concentration of thrombin and the increased rate of its generation. At the same time, the time of prothrombinase complex activation and that of thrombin generation were longer than those in the control group. In the early postoperative period, the patients who had not been transfused with platelet concentrates with a further increase in the temporal parameters, showed a decreased hemostatic potential, reaching the control level, whereas donor platelet transfusion stimulated endogenous thrombin generation: the time to initiate clotting and that to reach the peak were shorter; in this case, the thrombin generation rate and concentrations increased, but the preoperative level was not reached. No perioperative (hemorrhagic or thrombotic ischemic) events were noted in the examined groups. Conclusion. The hemostatic potential was preserved in patients receiving long-term therapy for ASA. Taking into account laboratory and clinical findings, platelet concentrate transfusions are unnecessary for preventive purposes. The appropriateness of donor platelet transfusion should be strictly individually approached with regard to the laboratory parameters of the thrombin generation test, by minimizing the risk of perioperative ischemic and hemorrhagic events in each specific patient.

scholarly journals Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Anne Sofie Gram ◽  
Martin Bæk Petersen ◽  
Jonas Salling Quist ◽  
Mads Rosenkilde ◽  
Bente Stallknecht ◽  
...  
Keyword(s):  
Thrombin Generation ◽  
Leisure Time ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Fibrin Clot ◽  
Overweight And Obesity ◽  
Active Commuting ◽  
Long Term Effects

Obesity and exercise constitute important factors for cardiovascular disease risk, but the long-term effects of different exercise modalities on haemostatic biomarkers are not well elucidated. We investigated the effects of 6 months of active commuting or leisure-time exercise on measures of fibrin turnover in individuals who are overweight and obese. Ninety younger (20–40 years), sedentary, healthy women and men who are overweight and obese (BMI: 25–35 kg/m2) were randomised to 6 months of habitual lifestyle (CON, n=16), active commuting (BIKE, n=19), or leisure-time exercise of moderate (MOD, ∼50% VO2peak reserve, n=31) or vigorous intensity (VIG, ∼70% VO2peak reserve, n=24). Fasting blood samples (baseline and 3 and 6 months) were analysed for cholesterols and triglycerides, thrombin generation, prothrombin fragment 1 + 2, D-dimer, fibrin clot properties, and fibrinolytic activity. We observed no differences between CON, BIKE, MOD, and VIG during the intervention and no time effects for any of the variables measured despite increased VO2peak in all exercise groups. We found no difference between CON and all exercise groups combined and no gender-specific effects of exercise. Our findings suggest that thrombin generation capacity, coagulation activation, fibrin clot structure, and lysability are unaffected by long-term active commuting and leisure-time exercise in women and men who are overweight and obese.

Effects of Soy Bean Trypsin Inhibitor on Fibrin Clot Lysis

1966 ◽  
Vol 15 (03/04) ◽  
pp. 542-553 ◽  
Author(s):  
K Egeblad
Keyword(s):  
Human Plasma ◽  
Blood Coagulation ◽  
Trypsin Inhibitor ◽  
Thrombin Generation ◽  
Inhibitory Effect ◽  
Fibrin Clot ◽  
Combined Effect ◽  
Clot Lysis ◽  
Bean Trypsin Inhibitor ◽  
Inhibitory Agents

SummaryThe effect of soy bean trypsin inhibitor (SBTI) on fibrinolysis and blood coagulation was investigated. Clot lysis was recorded by means of thrombelastography. SBTI delays fibrinolysis induced by plasmin and by activators of plasminogen (SK-activator and urokinase). Activator-induced lysis is delayed by a combined effect on activator and plasmin. There appears to exist an equilibrium between highly dissociated compounds of inhibitor with the active agents. The inhibitory effect of SBTI is relatively decreased in clots containing human plasma probably caused by an equilibrium with inhibitory agents in the plasma. SBTI delays thrombin generation in recalcified plasma as well as the effect of thromboplastin, but the effect is weak and requires a concentration 70-100 fold the antifibrinolytic active. The effect on thrombosis is even weaker.

scholarly journals Wave propagation for a reduced model of blood coagulation

2020 ◽  
Vol 31 ◽  
pp. 01005
Author(s):  
Nicolas Ratto ◽  
Martine Marion ◽  
Vitaly Volpert
Keyword(s):  
Wave Propagation ◽  
Mathematical Models ◽  
Blood Coagulation ◽  
Thrombin Generation ◽  
Reduced Model ◽  
Generation Test

Reduced mathematical models of blood coagulation can properly describe Thrombin Generation Test (TGT). Clot growth occurs as a reactiondiffusion wave, and the reduced model studied in this work describes this behaviour, preserving the differences observed between healthy and hemophilia subjects in the TGT.

Acute Pancreatitis in Man and Blood Coagulation Disturbances

1979 ◽  
Author(s):  
H. Kõtering ◽  
M. Hasenbein ◽  
H. Artmann ◽  
U. Kasten ◽  
J. Kellermann
Keyword(s):  
Acute Pancreatitis ◽  
Blood Coagulation ◽  
Thrombin Generation ◽  
The Other ◽  
Phospholipase A ◽  
Coagulation System ◽  
Consumption Coagulopathy ◽  
Blood Coagulation System ◽  
Severe Pancreatitis ◽  
Generation Test

The pathogenesis of blood coagulation-disturbances in patients with acute pancreatitis in man is still unknown. Therefore we studied repeatedly the blood coagulation system of all patients with acute pancreatitis, who were admitted to our clinic or were transferred from other hospitals after complications occurred. 19 patients with a severe pancreatitia were studied. Most of them showed oliguria, pancreatic lungs, thrombosis or haemorrhage. Only 9 determinations (in 5 patients) resulted an enhancement of thrombin generation in the Thrombin-Generation-Test (TGT). All the other patients showed already hypocoagulsbility in the TGT and severe signs of DIC and consumption coagulopathy with a loss of platelets, fibrinogen and prothrombin complex. In 9 patients, who died, we found histomorphologicaliy fibrin deposites and hyaline thrombi. In comparison to 58 patients with elevated amylases but no severe pancreatitiS we found, that the initial alteration of blood coagulation system in pancreatitis is a hypercoagulaoility, possibly caused by trypsin, phospholipase A or elastase.

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