scholarly journals Nanoparticles : Non-invasive Biomedical Imaging Agents

2021 ◽  
Vol 2 (4) ◽  
Keyword(s):  
Biomedical Imaging ◽  
Imaging Agents ◽  
Non Invasive

scholarly journals Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging

2018 ◽  
Vol 6 (4) ◽  
pp. 550-555 ◽  
Author(s):  
F. Zamberlan ◽  
L. Turyanska ◽  
A. Patanè ◽  
Z. Liu ◽  
H. E. L. Williams ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Biomedical Imaging ◽  
Near Infrared ◽  
Non Invasive ◽  
Pbs Nanocrystals ◽  
Pbs Quantum Dots

Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.

scholarly journals Metal-based imaging agents: progress towards interrogating neurodegenerative disease

2020 ◽  
Vol 49 (10) ◽  
pp. 2886-2915 ◽  
Author(s):  
Adam C. Sedgwick ◽  
James T. Brewster ◽  
Peter Harvey ◽  
Diana A. Iovan ◽  
Graham Smith ◽  
...  
Keyword(s):  
Transition Metals ◽  
Neurodegenerative Disease ◽  
Lanthanide Ions ◽  
Diagnostic Tools ◽  
Imaging Agents ◽  
Non Invasive

Transition metals and lanthanide ions display unique properties that enable the development of non-invasive diagnostic tools for imaging. In this review, we highlight various metal-based imaging strategies used to interrogate neurodegeneration.

scholarly journals Supramolecular Encapsulation of Small-Ultra Red Fluorescent Proteins in Virus-Like Nanoparticles for Non-Invasive In Vivo Imaging Agents

2020 ◽  
Author(s):  
Fabian C. Herbert ◽  
Olivia Brohlin ◽  
Tyler Galbraith ◽  
Candace Benjamin ◽  
Cesar A. Reyes ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Ex Vivo ◽  
Imaging Agents ◽  
Non Invasive ◽  
Red Fluorescent Proteins ◽  
Ex Vivo Imaging

<div> <div> <div> <p>Icosahedral virus-like particles (VLPs) derived from bacteriophages Qβ and PP7 encapsulating small-ultra red fluorescent protein (smURFP) were produced using a versatile supramolecualr capsid dissassemble-reassemble approach. The generated fluorescent VLPs display identical structural properties to their non-fluorescent analogs. Encapsulated smURFP shows indistinguishable photochemical properties to its unencapsulated counterpart, exhibits outstanding stability towards pH, and produces bright in vitro images following phagocytosis by macrophages. In vivo imaging allows biodistribution to be imaged at different time points. Ex vivo imaging of intravenously administered encapsulated smURFP reveleas localization in the liver and </p> </div> </div> <div> <div> <p>kidneys after 2 h blood circulation and substantial elimination constructs as non-invasive in vivo imaging agents. </p> </div> </div> </div>

Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications

2020 ◽  
Vol 20 (17) ◽  
pp. 1767-1780 ◽  
Author(s):  
Huan Yue ◽  
Ja Young Park ◽  
Yongmin Chang ◽  
Gang Ho Lee
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Biomedical Imaging ◽  
Mri Contrast Agents ◽  
Polyol Synthesis ◽  
Imaging Agents ◽  
Bibliographic Databases ◽  
Mri Contrast ◽  
X Ray

Imaging agents are crucial in diagnosing diseases. Ultrasmall lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Eu, Gd, and Dy) are promising materials as high-performance imaging agents because of their excellent magnetic, optical, and X-ray attenuation properties which can be applied as magnetic resonance imaging (MRI), fluorescence imaging (FI), and X-ray computed tomography (CT) agents, respectively. Ultrasmall Ln2O3 NPs (Ln = Eu, Gd, and Dy) are reviewed here. The reviewed topics include polyol synthesis, characterization, properties, and biomedical imaging applications of ultrasmall Ln2O3 NPs. Recently published papers were used as bibliographic databases. A polyol method is a simple and efficient one-pot synthesis for preparing ultrasmall Ln2O3 NPs. Ligand-coated ultrasmall Ln2O3 NPs have good colloidal stability, biocompatibility, and renal excretion ability suitable for in vivo imaging applications. Ultrasmall Eu2O3 NPs display photoluminescence in the red region suitable for use as FI agents. Ultrasmall Gd2O3 NPs have r1 values higher than those of commercial molecular contrast agents and r2/r1 ratios close to 1, which make them eligible for use as T1 MRI contrast agents. Ultrasmall Dy2O3 NPs exhibit high r2 and negligible r1 values, which make them suitable for use as T2 MRI contrast agents. All ultrasmall Ln2O3 NPs have high X-ray attenuation powers which make them suitable for use as CT contrast agents. Unmixed, mixed, or doped ultrasmall Ln2O3 NPs with different Ln are extremely useful for in vivo imaging applications in MRI, CT, FI, MRI-CT, MRI-FI, CT-FI, and MRI-CT-FI.

POLYMER-MODIFIED GADOLINIUM NANOPARTICLES FOR TARGETED MAGNETIC RESONANCE IMAGING AND THERAPY

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 263-275 ◽  
Author(s):  
STEPHEN G. BOYES ◽  
MISTY D. ROWE ◽  
NATALIE J. SERKOVA ◽  
FERNANDO J. KIM ◽  
JAMES R. LAMBERT ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Molecular Probes ◽  
Imaging Agents ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Gene And Protein Expression ◽  
Wide Range

Functional imaging is a novel area in radiological sciences and allows for the non-invasive assessment and visualization of specific targets such as gene and protein expression, metabolic rates, and drug delivery in intact living subjects. As such, the field of molecular imaging has been defined as the non-invasive, quantitative, and repetitive imaging of biomolecules and biological processes in living organisms. For example, cancer cells may be genetically altered to attract molecules that alter the magnetic susceptibility, thereby permitting their identification by magnetic resonance imaging. These contrast agents and/or molecular reporters are seen as essential to the task of molecular medicine to increase both sensitivity and specificity of imaging. Therefore, there are five general principles which need to be fulfilled in order to conduct a successful in vivo molecular imaging study: (1) selection of appropriate cellular and subcellular targets; (2) development of suitable in vivo affinity ligands (molecular probes); (3) delivery of these probes to the target organ; (4) amplification strategies able to detect minimal target concentrations; and (5) development of imaging systems with high resolution. Although there has been a wide range of routes taken to incorporate both imaging agents and a disease-targeting moiety into diagnostic devices, arguably the most interesting of these routes employs the use of nanoparticles. Nanoscale diagnostic systems that incorporate molecular targeting agents and diagnostic imaging capabilities are emerging as the next-generation imaging agents and have the potential to dramatically improve the outcome of the imaging, diagnosis, and treatment of a wide range of diseases. The present review addresses chemical aspects in development of molecular probes based upon gadolinium nanoparticles and their potential role in translational clinical imaging and therapy.

scholarly journals Recent Advances in Higher-Order, Multimodal, Biomedical Imaging Agents

Small ◽  
2015 ◽  
Vol 11 (35) ◽  
pp. 4445-4461 ◽  
Author(s):  
James Rieffel ◽  
Upendra Chitgupi ◽  
Jonathan F. Lovell
Keyword(s):  
Biomedical Imaging ◽  
Higher Order ◽  
Imaging Agents ◽  
Recent Advances

Quenched hexacene optoacoustic nanoparticles

2018 ◽  
Vol 6 (1) ◽  
pp. 44-55 ◽  
Author(s):  
Antonio Nunes ◽  
Vikram J. Pansare ◽  
Nicolas Beziere ◽  
Argiris Kolokithas Ntoukas ◽  
Josefine Reber ◽  
...  
Keyword(s):  
Biomedical Imaging ◽  
Imaging Agents ◽  
Optoacoustic Imaging ◽  
Flash Nanoprecipitation ◽  
Strong Signal ◽  
The Creation

Flash NanoPrecipitation allows for the creation of optoacoustic imaging agents with tunable size and strong signal for biomedical imaging and therapy.

scholarly journals Supramolecular Encapsulation of Small-Ultra Red Fluorescent Proteins in Virus-Like Nanoparticles for Non-Invasive In Vivo Imaging Agents

2020 ◽  
Author(s):  
Fabian C. Herbert ◽  
Olivia Brohlin ◽  
Tyler Galbraith ◽  
Candace Benjamin ◽  
Cesar A. Reyes ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Ex Vivo ◽  
Imaging Agents ◽  
Non Invasive ◽  
Red Fluorescent Proteins ◽  
Ex Vivo Imaging

<div> <div> <div> <p>Icosahedral virus-like particles (VLPs) derived from bacteriophages Qβ and PP7 encapsulating small-ultra red fluorescent protein (smURFP) were produced using a versatile supramolecualr capsid dissassemble-reassemble approach. The generated fluorescent VLPs display identical structural properties to their non-fluorescent analogs. Encapsulated smURFP shows indistinguishable photochemical properties to its unencapsulated counterpart, exhibits outstanding stability towards pH, and produces bright in vitro images following phagocytosis by macrophages. In vivo imaging allows biodistribution to be imaged at different time points. Ex vivo imaging of intravenously administered encapsulated smURFP reveleas localization in the liver and </p> </div> </div> <div> <div> <p>kidneys after 2 h blood circulation and substantial elimination constructs as non-invasive in vivo imaging agents. </p> </div> </div> </div>

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