Effect of transcranial direct current stimulation of stroke patients on depression and quality of life

Abstract Background Persistent pain can lead to incapacitation requiring long-term pharmacological treatment. Up to 82% of chronic kidney disease (CKD) patients undergoing hemodialysis (HD) have chronic pain and most do not respond to usual medication. Advances in non-pharmacological treatments are necessary to promote pain relief without side effects and to restore functionality. Transcranial direct current stimulation (tDCS) promises to be a novel, cost-efficient, non-pharmacological treatment for CKD patients with chronic pain. In this study, we hypothesize that tDCS could improve pain, depression, functionality, and quality of life in patients with CKD undergoing HD. Methods/design We describe a single-center, parallel-design, double blind randomized, sham-controlled trial. Forty-five subjects with CKD undergoing HD will be randomized to a motor cortex (M1), a dorso lateral prefrontal cortex (DLPFC), or a sham group. A total of ten sessions will be administered to participants over 4 weeks using a monophasic continuous current with an intensity of 2 mA for 20 min. Participants will be evaluated at baseline, immediately after the tenth session, and at 1 week and 4 weeks of follow-up after the intervention. Pain, depression, functionality, and quality of life will be evaluated. Discussion The results from this study will provide initial clinical evidence on the efficacy and safety of tDCS in patients with CKD undergoing HD. Trial registration Brazilian Clinical Trials Registry/Registro Brasileiro de Ensaios Clínicos (ensaiosclinicos.gov.br), 1111–1216-0137. Registered on 20 June 2018.

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2056-P: Psychiatric Profile and Quality of Life in Subjects with Excess Weight Treated with Transcranial Direct Current Stimulation Combined with Hypocaloric Diet

Diabetes ◽

10.2337/db19-2056-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2056-P

Author(s):

GABRIELLA RICHTER NATIVIDADE ◽

CARINA DE ARAUJO ◽

RAQUEL C. FITZ ◽

AMANDA F. OSÓRIO ◽

PAULA NUNES MERELLO ◽

...

Keyword(s):

Quality Of Life ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Excess Weight ◽

Hypocaloric Diet ◽

Direct Current Stimulation

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Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients

European Journal of Neurology ◽

10.1111/j.1468-1331.2012.03703.x ◽

2012 ◽

Vol 20 (1) ◽

pp. 202-204 ◽

Cited By ~ 87

Author(s):

C. Rossi ◽

F. Sallustio ◽

S. Di Legge ◽

P. Stanzione ◽

G. Koch

Keyword(s):

Acute Stroke ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Stroke Patients ◽

Direct Current Stimulation ◽

Stimulation Of

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Comparison of the effects of transcranial direct current stimulation and mindfulness-based stress reduction on mental fatigue, quality of life and aggression in mild traumatic brain injury patients: a randomized clinical trial

Annals of General Psychiatry ◽

10.1186/s12991-021-00355-1 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Sheida Shirvani ◽

Mohammadreza Davoudi ◽

Masoud Shirvani ◽

Peiman Koleini ◽

Safora Hojat Panah ◽

...

Keyword(s):

Quality Of Life ◽

Direct Current ◽

Stress Reduction ◽

Transcranial Direct Current Stimulation ◽

Mental Fatigue ◽

Direct Current Stimulation ◽

Significant Difference ◽

The World ◽

Mindfulness Based Stress Reduction

Abstract Background The rate of traumatic brain injuries (TBIs) due to the accidents is high around the world. Patients with mild TBIs may suffer from some psychological disorders, including aggression, and mental fatigue, and thus their quality of life decreased. Among different treatments for TBI, two treatments, namely transcranial direct current stimulation (tDCS), and mindfulness-based stress reduction (MBSR) have shown to be effective. Therefore, this study aimed to compare the effects of these two treatments on mental fatigue, aggression and quality of life in mTBI patients. Materials and methods This randomized controlled trial study was conducted on 48 TBI patients referred to emergency and neurosurgery departments of Shahid Beheshti Hospital, Kashan, Iran. They were selected using the convenience sampling method. Data were collected using the mental fatigue scale, the World Health Organization Quality of Life-BREF (short version), and the Buss–Perry Aggression Questionnaires. Then, the data were analyzed using a Mixed Repeated Measures ANOVAs, and the Levene and Kolmogorov–Smirnov tests by SPSS-23 software. Results The mean age of patients in the three groups of MBSR, tDCS and control were 69.38 + 6.11 (25% male), 25.40 + 12.11 (25% male) and 69.37 + 0.2 (18.8% male), respectively. There was no significant difference between the three groups in terms of mental fatigue, quality of life and aggression (P < 0.05). In addition, the results showed that there was a significant difference between the main effect of time and the interaction between time and group (P < 0.001). Conclusions Both MBSR and tDCS methods are effective in reducing the mental fatigue and aggression and increasing quality of life of mTBI patients; MBSR treatment, as indicated in the present study, can be more effective than tDCS in patients with mTBI. Trial registration : Thailand Registry of Clinical Trials, TCTR20180827003 Registered on August 24, 2018.

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Transcranial direct current stimulation (tDCS) for improving health -related quality of life, disability and impairment in patients with idiopathic Parkinson's disease

10.1002/14651858.cd010916 ◽

2014 ◽

Author(s):

Bernhard Elsner ◽

Joachim Kugler ◽

Marcus Pohl ◽

Jan Mehrholz

Keyword(s):

Quality Of Life ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Idiopathic Parkinson’S Disease ◽

Health Related Quality ◽

Direct Current Stimulation ◽

Idiopathic Parkinson's Disease ◽

Related Quality ◽

Health Related

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Determining the effects of transcranial direct current stimulation on tinnitus and tinnitus-related outcomes: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2020-047191 ◽

2021 ◽

Vol 11 (3) ◽

pp. e047191

Author(s):

Bas Labree ◽

Derek J Hoare ◽

Lauren E Gascoyne ◽

Magdalena Sereda

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Adverse Effects ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Ethical Issues ◽

Future Research ◽

Direct Current Stimulation ◽

Meta Analyses

IntroductionTinnitus is the awareness of a sound in the ear or head in the absence of an external source. It affects around 10%–15% of people. About 20% of people with tinnitus also experience symptoms such as depression or anxiety that negatively affect their life. Transcranial direct current stimulation (tDCS) is a technique involving constant low-intensity direct current delivered via electrodes on the head. It is postulated to modulate (suppress or enhance) neural activity in the region between electrodes. As such, it represents a potential treatment option for tinnitus, as well as comorbid depression or anxiety. This systematic review will estimate the effects of tDCS on outcomes relevant to tinnitus. In addition, it will determine whether there is any relationship between stimulation parameters (electrode montage, current intensity, and length and frequency of stimulation sessions) and the effect of tDCS on these outcomes.Methods and analysisElectronic searches for peer-reviewed journal articles will be performed in the Cochrane Register of Studies online (the Cochrane Ear, Nose and Throat Disorders Group Register and CENTRAL, current issue), PubMed, EMBASE, CINAHL, LILACS, KoreaMed, IndMed, PakMediNet, CNKI, AMED, PsycINFO, Web of Science, ClinicalTrials.gov, ICTRP and Google Scholar using the following search terms: transcranial Direct Current Stimulation OR tDCS AND tinnitus OR depression OR anxiety OR quality of life OR adverse effects OR neurophys*.Searches were not limited by date. Methods are reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Randomised controlled trials will be included if they report at least one of the following outcomes: tinnitus symptom severity, anxiety or depression as measured by relevant validated instruments. Where available, data on quality of life, adverse effects and neurophysiological changes will also be reviewed. In addition to an analysis of the effect of each parameter, an analysis will be performed to uncover any interactions between parameters. Where appropriate, meta‐analyses will be performed.Ethics and disseminationThis systematic review will make use of secondary data only. As no data will be obtained from participants directly, ethical approval has not been sought. No other ethical issues are foreseen. Findings will be submitted for peer-reviewed publication and presented at academic conferences. The results of this review will inform future research.PROSPERO registration numberCRD42020185567.

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To Combine or Not to Combine Physical Therapy With tDCS for Stroke With Shoulder Pain? Analysis From a Combination Randomized Clinical Trial for Rehabilitation of Painful Shoulder in Stroke

Frontiers in Pain Research ◽

10.3389/fpain.2021.696547 ◽

2021 ◽

Vol 2 ◽

Author(s):

Janaina Andressa de Souza ◽

João Carlos Ferrari Corrêa ◽

Anna Marduy ◽

Letizzia Dall'Agnol ◽

Maria Helena Gomes de Sousa ◽

...

Keyword(s):

Quality Of Life ◽

Physical Therapy ◽

Range Of Motion ◽

Shoulder Pain ◽

Motor Function ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Direct Current Stimulation ◽

Significant Difference

Purpose: Transcranial Direct Current Stimulation (tDCS) is an intervention that seems to be an ideal tool to enhance the effects of rehabilitation therapies given it facilitates generation of plasticity in the stimulated brain area. In stroke this strategy has been highly utilized; however, the results have been mixed. In this trial we have evaluated the analgesic and functional effects of Transcranial Direct Current Stimulation (tDCS) combined with physiotherapy in stroke survivors with shoulder pain.Methods: Twenty-six stroke surviving adults with shoulder pain received 10 sessions of passive mobilization and performed upper limb exercises using a cycle ergometer, combined with active or sham tDCS. The intensity of pain in the hemiplegic shoulder was measured using the Visual Analog Scale (VAS); secondary outcomes were the level of motor impairment, handgrip strength, range of motion, motor function of the upper limbs, and quality of life (QOL) assessed before and after 10 sessions and 1 month after the end of the treatment.Results: A clinically important pain reduction (3 points) was found in both groups and was maintained at follow-up; there was no significant difference between groups (p = 0.3). Similarly, the shoulder range of motion improved, motor function and quality of life improved showed no significant differences between groups. One result that needs to be underscored is that both groups had a significant effect size toward improvement in all of these outcomes.Conclusions: We discuss in this study that tDCS is not a useful combination strategy when the physical therapy has a large effect by itself and we also review other negative trials of combined therapy under this framework of ceiling effect of the main physical therapy.Trial registry: Trial registration: Brazilian Registry of Clinical Trials, RBR-8F5MNY (http://www.ensaiosclinicos.gov.br/rg/RBR-8f5mny/). Registered on June 2, 2017.Beginning of the recruitment of the volunteers: august, 2017.

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