scholarly journals Language impairment in the moderate stage of dementia due to Alzheimer's disease

2021 ◽  
Vol 79 (4) ◽  
pp. 283-289
Author(s):  
Karin Zazo ORTIZ ◽  
Juliana Onofre DE LIRA ◽  
Thais Soares Ciariancullo MINETT ◽  
Paulo Henrique Ferreira BERTOLUCCI
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Language Disorder ◽  
Normal Population ◽  
Naming Task ◽  
Language Impairments ◽  
Semantic Cues ◽  
Written Word ◽  
Therapeutic Doses

ABSTRACT Background: During the moderate stage of dementia due to Alzheimer’s disease (AD), language disorder is more evident and it impacts on communication. An overview of language impairment could be helpful to find compensatory communication strategies for these patients. Objective: To identify all language impairments among patients with moderate-stage of AD. Methods: 20 patients diagnosed with probable AD based on the criteria of the NINCDS-ARDRA, with a MMSE score of 13-23 points and CDR=2, who were undergoing treatment for AD with therapeutic doses of acetyl cholinesterase inhibitors, were assessed using the Boston Diagnostic Aphasia Examination (BDAE), a test that provides a broad assessment of language. The results were compared with the performance of a normal population. Results: The patients assessed in this study presented normal scores for oral and written word recognition, repetition, mechanics of writing, primer-level dictation and spelling to dictation but also had impairment at most levels of linguistic processing, in oral and written comprehension and production. In general, as expected, the tasks relying on access to the mental lexicon were most significantly affected. However, they performed well in the naming task, in which semantic cues were presented. Moreover, the patients assessed in this study had better performance in written comprehension tasks than in oral ones. Conclusion: The severity of the language impairments was not homogenous, with some linguistic abilities more impaired than others. The abilities that were found to be preserved can help to guide strategies for aiding in communication at this stage of AD.

Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer’s Disease Biomarkers

2021 ◽  
pp. 1-13
Author(s):  
Sung Hoon Kang ◽  
Hanna Cho ◽  
Jiho Shin ◽  
Hang-Rai Kim ◽  
Young Noh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Amyloid Β ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Clinical Feature ◽  
Progressive Aphasia ◽  
Disease Biomarkers ◽  
Primary Progressive

Background: Primary progressive aphasia (PPA) is associated with amyloid-β (Aβ) pathology. However, clinical feature of PPA based on Aβ positivity remains unclear. Objective: We aimed to assess the prevalence of Aβ positivity in patients with PPA and compare the clinical characteristics of patients with Aβ-positive (A+) and Aβ-negative (A–) PPA. Further, we applied Aβ and tau classification system (AT system) in patients with PPA for whom additional information of in vivo tau biomarker was available. Methods: We recruited 110 patients with PPA (41 semantic [svPPA], 27 non-fluent [nfvPPA], 32 logopenic [lvPPA], and 10 unclassified [ucPPA]) who underwent Aβ-PET imaging at multi centers. The extent of language impairment and cortical atrophy were compared between the A+ and A–PPA subgroups using general linear models. Results: The prevalence of Aβ positivity was highest in patients with lvPPA (81.3%), followed by ucPPA (60.0%), nfvPPA (18.5%), and svPPA (9.8%). The A+ PPA subgroup manifested cortical atrophy mainly in the left superior temporal/inferior parietal regions and had lower repetition scores compared to the A–PPA subgroup. Further, we observed that more than 90%(13/14) of the patients with A+ PPA had tau deposition. Conclusion: Our findings will help clinicians understand the patterns of language impairment and cortical atrophy in patients with PPA based on Aβ deposition. Considering that most of the A+ PPA patents are tau positive, understanding the influence of Alzheimer’s disease biomarkers on PPA might provide an opportunity for these patients to participate in clinical trials aimed for treating atypical Alzheimer’s disease.

Language Impairment and Rate of Cognitive Decline in Alzheimer's Disease

1994 ◽  
Vol 5 (6) ◽  
pp. 334-338 ◽  
Author(s):  
Marie-Claire Goldblum ◽  
Catherine Tzortzis ◽  
Jean-Luc Michot ◽  
Michel Panisset ◽  
François Boller
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Language Impairment

Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients

2013 ◽  
Vol 25 (2) ◽  
pp. 66-76 ◽  
Author(s):  
Yaping Hou ◽  
Huayun Chen ◽  
Qiong He ◽  
Wei Jiang ◽  
Tao Luo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Methylation Level ◽  
Target Genes ◽  
Normal Population ◽  
Cpg Islands ◽  
Methylation Pattern ◽  
Control Group ◽  
Specific Pcr

BackgroundEfforts aiming at identifying biomarkers and corresponding methods for early diagnosis of Alzheimer's disease (AD) might be the most appropriate strategy to initiate promising new treatments and/or prevention of ADObjectiveThe aim of our study is to assess the association of DNA methylation pattern of various leucocyte genes with AD pathogenesis in order to find potential biomarkers and corresponding methods for molecular diagnosis of AD.MethodsDNA methylation level of various genes in AD patients and normal population were compared by bisulphite sequencing PCR and methylation-specific PCR (MSP). Furthermore, real-time PCR was used to explore the effects of DNA methylation on the expression of target genes.ResultsResults showed significant hypermethylation of mammalian orthologue of Sir2 (SIRT1) gene in AD patients compared with normal population. Meanwhile, changes in methylation level of SIRT1 gene between different severities of AD were also found. Specific primers were designed from the SIRT1 CpG islands to differentiate AD and control group by MSP method. Besides, significant demethylation of β-amyloid precursor protein (APP) gene was observed in AD patients, whereas no difference was observed in other AD-related genes. Moreover, significant decrease in expression of SIRT1 gene and increase in expression of APP gene were also found in AD patients. In addition, the expression level of SIRT1/APP genes was associated with the severity, but not with the age or gender, of AD patients.Conclusion:SIRT1 and APP might be the interesting candidate biomarkers and valuable for clinical diagnosis or treatment of AD.

scholarly journals Narrativity Analysis in Alzheimer’s Disease

2018 ◽  
Author(s):  
P Thomas ◽  
R Billon ◽  
C Hazif-Thomas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Neuropsychological Tests ◽  
Memory Impairment ◽  
Regression Coefficient ◽  
University Hospital ◽  
Sociodemographic Data ◽  
Pls Analysis ◽  
Fluency Test

Context. Alzheimer’s Disease (AD) is a neurodegenerative illness with frequency of occurrence increasing with old age. If memory impairment setting progressively in is here an element associated upfront, other neurocognitive troubles are also associated, for example, language impairment which can degenerate into aphasia. Aim of the study. To evaluate semantic and textual impairment in AD. Methods. Populationsstudied concerned 151 AD patients in consultation at Brest University Hospital. Certain sociodemographic data (sex, age, cultural levels) were collected as well as results from neuropsychological tests: (Folstein – MMSE; Dubois’s 5-word test; fluencies, Dubois’ s frontal test battery; Cornell’s scale for depression; Barbizet’s test, “The Lion’s tale”, for textual analysis. Demented patients were composed of 102 females and 49 males of average age 80.3 ± 6.91. All the tests, including the number of items memorized latterly in the Barbizet’s test are impaired all the more by Folstein’s test being altered. The formal fluency on demented patients is less impaired than the semantical lexical fluency test (scored respectively 5.74 ± 1. 09 versus 4.41 ± 2. 19;t= 5.60, p<0.01). The studied demented cohort shows more intrusions (n=36) than inversions in the delayed Lion’s tale, whether for items or for episodes in which they occur (n=19). The regressive PLS analysis shows that for the explanation of the overall scores to do with “The lion’s tale”, calculated later, only attainment of lexical fluency has any notable influence (Regression coefficient CR=0.224) or, more accessorily, the cultural level (CR=0.12). Conclusions. Attainment of category fluency and patient culture levels have effects on narrativity. Keywords: Alzheimer’s Disease, semiotics, semantics, textuality

scholarly journals Oral and Written Naming in Alzheimer’s Disease: A Longitudinal Study

2018 ◽  
Vol 15 (12) ◽  
pp. 1142-1150 ◽  
Author(s):  
Maria Gonzalez-Nosti ◽  
Fernando Cuetos ◽  
Carmen Martinez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oral Language ◽  
Picture Naming ◽  
Naming Task ◽  
Cross Sectional ◽  
Healthy Elderly ◽  
Naming Tasks ◽  
Better Than

Background: The expressive difficulties in patients with Alzheimer’s dementia have been extensively studied, mainly in oral language. However, the deterioration of their writing processes has received much less attention. Objective: The present study aims to examine the decline of the performance of patients with Alzheimer’s disease in both oral and written picture-naming tasks. Method: Sixty-four participants (half with Alzheimer’s disease and half healthy elderly) were compared in the oral and written versions of a picture-naming task. Follow-up lasted two and a half years and patients were evaluated every six months. Results: Cross-sectional data indicate that the controls performed better than the patients, and both groups showed a different pattern of errors. In terms of longitudinal data, the results show a similar pattern of deterioration in both tasks. In terms of errors, lexical-semantics were the most numerous at the beginning and their number remained constant throughout all evaluations. In the case of non-responses, there was a significant increase in the last session, both in oral and written naming. Conclusion: These results replicate those found in previous studies and highlight the utility of the naming task to detect minimal changes in the evolution of patients with Alzheimer’s disease.

The picture-naming task in the analysis of cognitive deterioration in Alzheimer's disease

Aphasiology ◽  
2005 ◽  
Vol 19 (6) ◽  
pp. 545-557 ◽  
Author(s):  
Fernando Cuetos ◽  
María Gonzalez-Nosti ◽  
Carmen Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Picture Naming ◽  
Naming Task ◽  
Cognitive Deterioration

Impaired production priming and intact identification priming in Alzheimer's disease

2001 ◽  
Vol 7 (7) ◽  
pp. 785-794 ◽  
Author(s):  
DEBRA A. FLEISCHMAN ◽  
LAURA A. MONTI ◽  
LISA M. DWORNIK ◽  
TERESA T. MORO ◽  
DAVID A. BENNETT ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Explicit Memory ◽  
Repetition Priming ◽  
Recognition Task ◽  
Naming Task ◽  
Word Naming ◽  
Stem Completion ◽  
Word Stem Completion ◽  
Identification Processes

This study examined the distinction between identification and production processes in repetition priming for 16 patients with Alzheimer's disease (AD) and 16 healthy old control participants (NC). Words were read in three study phases. In three test phases, participants (1) reread studied words, along with unstudied words, in a word-naming task (identification priming); (2) completed 3-letter stems of studied and unstudied words into words in a word-stem completion task (production priming); and (3) answered yes or no to having read studied and unstudied words in a recognition task (explicit memory). Explicit memory and word-stem completion priming were impaired in the AD group compared to the NC group. After correcting for baseline slowing, word-naming priming magnitude did not differ between the groups. The results suggest that the distinction between production and identification processes has promise for explaining the pattern of preservation and failure of repetition priming in AD. (JINS, 2001, 7, 785–794.)

scholarly journals Lexical Retrieval or Semantic Knowledge Which One Causes Naming Errors in Patients with Mild and Moderate Alzheimer’s Disease

2017 ◽  
Vol 7 (3) ◽  
pp. 419-429 ◽  
Author(s):  
Masoome Salehi ◽  
Mohsen Reisi ◽  
Leila Ghasisin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Subjects ◽  
Conceptual Knowledge ◽  
Semantic Knowledge ◽  
Elderly Subjects ◽  
Lexical Retrieval ◽  
Healthy Elderly ◽  
Written Word ◽  
Healthy Elderly Subjects

Background: The purpose of the study was to analyze naming errors in patients with Alz­heimer’s disease in comparison to healthy subjects and determine the underlying cause of naming errors in these patients. Method: In this study, we included 35 healthy elderly subjects, 23 patients with mild Alzheimer’s disease, and 23 with moderate Alzheimer’s disease. Forty-five images were used to determine the type of naming errors, and to identify the underlying cause of errors, matching an image with a written word was used. Results: Patients with Alz­heimer’s disease had more naming errors compared with the group of healthy elderly, and patients with moderate Alzheimer’s disease showed a slower reaction in matching an image with a written word. Conclusion: Anomia in the initial phase of Alzheimer’s disease is due to problems in lexical retrieval; however, as the disease advances, in addition to lexical retrieval problems, conceptual knowledge causes naming problems.

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