scholarly journals Oral and Written Naming in Alzheimer’s Disease: A Longitudinal Study

2018 ◽  
Vol 15 (12) ◽  
pp. 1142-1150 ◽  
Author(s):  
Maria Gonzalez-Nosti ◽  
Fernando Cuetos ◽  
Carmen Martinez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oral Language ◽  
Picture Naming ◽  
Naming Task ◽  
Cross Sectional ◽  
Healthy Elderly ◽  
Naming Tasks ◽  
Better Than

Background: The expressive difficulties in patients with Alzheimer’s dementia have been extensively studied, mainly in oral language. However, the deterioration of their writing processes has received much less attention. Objective: The present study aims to examine the decline of the performance of patients with Alzheimer’s disease in both oral and written picture-naming tasks. Method: Sixty-four participants (half with Alzheimer’s disease and half healthy elderly) were compared in the oral and written versions of a picture-naming task. Follow-up lasted two and a half years and patients were evaluated every six months. Results: Cross-sectional data indicate that the controls performed better than the patients, and both groups showed a different pattern of errors. In terms of longitudinal data, the results show a similar pattern of deterioration in both tasks. In terms of errors, lexical-semantics were the most numerous at the beginning and their number remained constant throughout all evaluations. In the case of non-responses, there was a significant increase in the last session, both in oral and written naming. Conclusion: These results replicate those found in previous studies and highlight the utility of the naming task to detect minimal changes in the evolution of patients with Alzheimer’s disease.

Evolution of writing impairment in spanish patients with alzheimer's disease

2020 ◽  
Vol 17 ◽  
Author(s):  
María González-Nosti ◽  
Fernando Cuetos ◽  
Carmen Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oral Language ◽  
Typical Pattern ◽  
Writing Difficulties ◽  
Healthy Elderly ◽  
Patient Performance ◽  
Contradictory Data ◽  
Early Damage

Background: Although some studies suggest that writing difficulties may be one of the early symptoms of Alzheimer's disease (AD), they have been scarcely studied compared to oral language. Particularly noteworthy is the paucity of longitudinal studies that enable the observation of writing impairment as cognitive decline progresses. Objective: The aim of this study was to examine the characteristics of writing in patients with AD and to monitor the deterioration of their performance over a follow-up period. Methods: Sixty-four participants (half with AD and half healthy elderly) were compared in a word and pseudo-word dictation task. Patients were evaluated every 6 months over a 2.5 year follow-up period. Results: The evolution of patient performance and error profile shows a typical pattern of deterioration, with early damage to the lexical pathway, which later extends to the phonological pathway and eventually affects peripheral processes. Conclusion: These results confirm the presence of writing difficulties from the early stages of AD, supporting the value of this task for early diagnosis. Furthermore, it allows us to explain the contradictory data obtained in previous investigations.

An Informant Questionnaire for Detecting Alzheimer's Disease: Are Some Items Better Than Others?

2011 ◽  
Vol 17 (4) ◽  
pp. 674-681 ◽  
Author(s):  
Sietske A.M. Sikkes ◽  
Dirk L. Knol ◽  
Mark T. van den Berg ◽  
Elly S.M. de Lange-de Klerk ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structural Equation ◽  
Structural Model ◽  
The Elderly ◽  
Equation Modeling ◽  
Or Education ◽  
Healthy Elderly ◽  
Patient Groups ◽  
Better Than

AbstractA decline in everyday cognitive functioning is important for diagnosing dementia. Informant questionnaires, such as the informant questionnaire on cognitive decline in the elderly (IQCODE), are used to measure this. Previously, conflicting results on the IQCODEs ability to discriminate between Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy elderly were found. We aim to investigate whether specific groups of items are more useful than others in discriminating between these patient groups. Informants of 180 AD, 59 MCI, and 89 patients with subjective memory complaints (SMC) completed the IQCODE. To investigate the grouping of questionnaire items, we used a two-dimensional graded response model (GRM).The association between IQCODE, age, gender, education, and diagnosis was modeled using structural equation modeling. The GRM with two groups of items fitted better than the unidimensional model. However, the high correlation between the dimensions (r=.90) suggested unidimensionality. The structural model showed that the IQCODE was able to differentiate between all patient groups. The IQCODE can be considered as unidimensional and as a useful addition to diagnostic screening in a memory clinic setting, as it was able to distinguish between AD, MCI, and SMC and was not influenced by gender or education. (JINS, 2011, 17, 674–681)

Gait analysis with videogrammetry can differentiate healthy elderly, mild cognitive impairment, and Alzheimer's disease: A cross-sectional study

2020 ◽  
Vol 131 ◽  
pp. 110816 ◽  
Author(s):  
Felipe de Oliveira Silva ◽  
José Vinícius Ferreira ◽  
Jéssica Plácido ◽  
Daniel Chagas ◽  
Jomilto Praxedes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gait Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Elderly

A Follow-Up Study of Actigraphic Measures in Home-Residing Alzheimer's Disease Patients

1998 ◽  
Vol 11 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Jerome A. Yesavage ◽  
Leah Friedman ◽  
Helena C. Kraemer ◽  
Art Noda ◽  
Deryl Wicks ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Circadian Rhythm ◽  
Behavioral Disturbance ◽  
Nocturnal Sleep ◽  
Significant Deterioration ◽  
Cross Sectional ◽  
Sleep Parameters ◽  
Rest Activity

This article reports cross-sectional and follow-up data with actigraphic measures of nocturnal sleep and rest/activity in 61 Alzheimer's disease (AD) patients as well as the relation of actigraphic measures to levels of behavioral disturbance across different stages of the disease. Over the course of approximately 1.5 years' follow-up, patients showed significant deterioration of nocturnal sleep parameters, but no significant change in rest/activity circadian rhythm parameters. There were also significant correlations among nocturnal sleep, rest/activity circadian rhythm, and behavioral disturbance measures, but only in relatively early stages of AD. It is argued that study of nocturnal sleep and circadian rhythm in relation to behavioral disturbance in AD requires longitudinal data and analyses that take into account the stage of disease at which patients are assessed.

The picture-naming task in the analysis of cognitive deterioration in Alzheimer's disease

Aphasiology ◽  
2005 ◽  
Vol 19 (6) ◽  
pp. 545-557 ◽  
Author(s):  
Fernando Cuetos ◽  
María Gonzalez-Nosti ◽  
Carmen Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Picture Naming ◽  
Naming Task ◽  
Cognitive Deterioration

Profiling spontaneous speech decline in Alzheimer's disease: a longitudinal study

2013 ◽  
Vol 25 (6) ◽  
pp. 320-327 ◽  
Author(s):  
Katrina Forbes-McKay ◽  
Michael F Shanks ◽  
Annalena Venneri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phonological Processing ◽  
Longitudinal Design ◽  
Spontaneous Speech ◽  
Speech Impairment ◽  
Cross Sectional ◽  
Description Task ◽  
Prospective Longitudinal

ObjectiveThis study aims to document the nature and progression of spontaneous speech impairment suffered by patients with Alzheimer's disease (AD) over a 12-month period, using both cross-sectional and prospective longitudinal design.MethodsThirty one mild–moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex oral description task at baseline. The AD patients then underwent follow-up assessments at 6 and 12 months.ResultsCross-sectional comparisons indicated that mild–moderate AD patients produced more word-finding delays (WFDs) and empty and indefinite phrases, while producing fewer pictorial themes, repairing fewer errors, responding to fewer WFDs, produce shorter and less complex phrases and produce speech with less intonational contour than controls. However, the two groups could not be distinguished on the basis of phonological paraphasias. Longitudinal follow-up, however, suggested that phonological processing deteriorates over time, where the prevalence of phonological errors increased over 12 months.DiscussionConsistent with findings from neuropsychological, neuropathological and neuroimaging studies, the language deterioration shown by the AD patients shows a pattern of impairment dominated by semantic errors, which is later joined by a disruption in the phonological aspects of speech.

Charting the decline in spontaneous writing in Alzheimer's disease: a longitudinal study

2014 ◽  
Vol 26 (4) ◽  
pp. 246-252 ◽  
Author(s):  
Katrina Forbes-McKay ◽  
Mike Shanks ◽  
Annalena Venneri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phonological Processing ◽  
Visual Processing ◽  
Longitudinal Design ◽  
Cross Sectional ◽  
Spontaneous Writing ◽  
Description Task ◽  
Prospective Longitudinal

ObjectiveThis study aims to document the nature and progression of the spontaneous writing impairment observed in patients with Alzheimer's disease (AD) over a 12-month period using both a cross-sectional and prospective longitudinal design.MethodsThirty-one minimal–moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex written description task at baseline. The AD patients then had follow-up assessments at 6 and 12 months.ResultsCross-sectional comparisons indicated that minimal–moderate AD patients produced more semantic paraphasias, phonological paraphasias, and empty and indefinite phrases, whilst producing fewer pictorial themes, repairing fewer errors, and producing shorter and less complex sentences than controls. The two groups could not be distinguished on visual paraphasias. Longitudinal follow-up, however, suggested that visual processing deteriorates over time, where the prevalence of visual errors increased over 12 months.DiscussionThe findings suggest that the deterioration of writing skills observed in the spontaneous writings of AD patients shows a pattern of impairment dominated by semantic errors with a secondary impairment in phonological processing, which is later joined by a disruption of visuospatial and graphomotor processing.

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