Nasal carriage rate of methicillin resistant Staphylococcus aureus among Iranian healthcare workers: a systematic review and meta-analysis

Background: Methicillin-resistant Staphylococcus aureus is one of the most common causes of nosocomial infections. Due to its multidrug resistant nature; infections due to Methicillin-resistant Staphylococcus aureus are often very difficult to treat. Colonized health care workers are the important sources of Methicillin-resistant Staphylococcus aureus. The objectives of this study were to determine the nasal carriage rate of Methicillin-resistant Staphylococcus aureus among health care workers at Kathmandu Medical College and Teaching Hospital, Nepal and to assess their antimicrobial susceptibility patterns.Methods: A cross sectional study was conducted among 252 health care workers from July to November 2013. Mannitol salt agar was used to culture the nasal swabs. Antimicrobial susceptibility testing was performed by Kirby- Bauer disc diffusion technique following Clinical and Laboratory Standards Institute guidelines. Methicillin-resistant Staphylococcus aureus strains were confirmed by using cefoxitin disc and by determining the minimum inhibitory concentration of oxacillin by agar dilution method.Results: Of 252 healthcare workers, 46(18.3%) were positive for Staphylococcus aureus among which 19(41.3%) were Methicillin-resistant Staphylococcus aureus carriers. Overall rate of nasal carriage of Methicillin-resistant Staphylococcus aureus was 7.5% (19/252).The higher percentages of lab personnel were nasal carriers of S. aureus (31.6%) and Methicillin-resistant Staphylococcus aureus (10.5%).The percentages of nasal carriage of S. aureus (35.7%) and Methicillinresistant Staphylococcus aureus (14.3%) were highest in the health care workers from post operative department. Higher percentage of Methicillin-resistant Staphylococcus aureus were susceptible toward amikacin (100%) and vancomycin (100%) followed by cotrimoxazole (84.2%).Conclusions: High rates of nasal carriage of S. aureus and Methicillin-resistant Staphylococcus aureus were observed among the healthcare workers, which indicate the need of strict infection control measures to be followed to control the nosocomial infections.

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Optimal trough concentration of teicoplanin for the treatment of methicillin‐resistant Staphylococcus aureus infection: A systematic review and meta‐analysis

Journal of Clinical Pharmacy and Therapeutics ◽

10.1111/jcpt.13366 ◽

2021 ◽

Author(s):

Yuki Hanai ◽

Yoshiko Takahashi ◽

Takashi Niwa ◽

Toshihiko Mayumi ◽

Yukihiro Hamada ◽

...

Keyword(s):

Systematic Review ◽

Staphylococcus Aureus ◽

Trough Concentration ◽

Methicillin Resistant Staphylococcus Aureus ◽

Meta Analysis ◽

Methicillin Resistant ◽

Aureus Infection

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PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS NASAL CARRIAGE IN HEALTHCARE WORKERS

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0b013e31817eeefa ◽

2008 ◽

Vol 27 (12) ◽

pp. 1109-1111 ◽

Cited By ~ 10

Author(s):

Maria Ibarra ◽

Tristan Flatt ◽

Diane Van Maele ◽

Aisha Ahmed ◽

Jaime Fergie ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Healthcare Workers ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Carriage ◽

Methicillin Resistant

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Nasal Carriage of Methicillin Resistant Staphylococcus aureus among Healthcare Workers in University of Maiduguri Teaching Hospital

Borno Medical Journal ◽

10.31173/bomj.bomj_164_16 ◽

2019 ◽

Vol 16 (2) ◽

pp. 01-08

Author(s):

Abubakar Adamu ◽

Hamman Ibrahim Garandawa ◽

AbZailani Sambo B ◽

Mohammad Y ◽

Aliyu Mohammad Kodiya ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Teaching Hospital ◽

Healthcare Workers ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Carriage ◽

Methicillin Resistant

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Systematic Review and Meta-analysis of Livestock Associated-Methicillin Resistant Staphylococcus aureus (LA-MRSA) Prevalence in Animals in India

International Journal of Livestock Research ◽

10.5455/ijlr.20180918100103 ◽

2019 ◽

pp. 1

Author(s):

Hamsapriya Sudhakar ◽

Krishnamoorthy Paramanandham ◽

Ashwini Mohan ◽

Sharanagouda Patil ◽

Parimal Roy ◽

...

Keyword(s):

Systematic Review ◽

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Meta Analysis ◽

Methicillin Resistant

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A cross sectional study to assess nasal carriage of methicillin resistant Staphylococcus aureus in healthcare professionals in a tertiary care hospital

Journal of the Pakistan Medical Association ◽

10.47391/jpma.062 ◽

2020 ◽

pp. 1-12

Author(s):

Fibhaa Syed ◽

Nasim Akhtar ◽

Mohammad Ali Arif ◽

Adil Ramzan ◽

Rauf Niazi ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Healthcare Workers ◽

Methicillin Resistant Staphylococcus Aureus ◽

Tertiary Care ◽

Nasal Carriage ◽

Cross Sectional Study ◽

Diffusion Method ◽

Cross Sectional ◽

Methicillin Resistant ◽

Nasal Swabs

Abstract Objective: To determine the nasal carriage of staphylococcus aureus and methicillin-resistant staphylococcus aureus among healthcare workers in a tertiary care setting. Methods: The cross-sectional study was conducted at the Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from April to July 2018, and comprised healthcare workers at the institution. Nasal swabs were collected and cultured on Mannitol salt agar. Mannitol fermenting colonies which were gram-positive cocci, catalase-positive and coagulase-positive were identified as staphylococcus aureus. Antibiotic susceptibility test was performed by modified Kirby-Bauer disc diffusion method. Methicillin resistance was detected using cefoxitin disc diffusion method. Data was analysed using SPSS 23. Results: Of the 210 nasal swabs, 52(24.76%) had a staphylococcus aureus growth, and, of them, 15(7.1%) were methicillin-resistant. No association could be established with either any single category of healthcare worker or an inter-department variation (p>0.05). Likewise, there was no association with age, gender, duration of service, smoking, co-morbidities, use of antibiotics in the preceding six months, treating a patient with methicillin-resistant staphylococcus aureus in the preceding six months and hospitalisation in the preceding year (p>0.05). Conclusion: The frequency of nasal carriage of methicillin resistant staphylococcus aureus amongst healthcare workers was regardless of the nature of their professional engagement. Key Words: Methicillin resistant staphylococcus aureus, Nasal carriage, Continuous...

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PREVALENCE OF NASAL CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AMONG HEALTHCARE WORKERS IN THE DEPARTMENTS OF OTORINOLARYNGOLOGY AND DENTISTRY IN KYIV, UKRAINE

Wiadomości Lekarskie ◽

10.36740/wlek202012101 ◽

2020 ◽

Vol 73 (12) ◽

pp. 2563-2567

Author(s):

Aidyn G. Salmanov ◽

Taras P. Bondar ◽

Yaroslav V. Shkorbotun ◽

Evelina A. Chumak ◽

Volodymyr O. Shkorbotun ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Virulence Factor ◽

Healthcare Workers ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Carriage ◽

Diffusion Method ◽

Methicillin Resistant ◽

Significant Difference ◽

Mrsa Strains ◽

Encoding Genes

The aim: To obtain the first estimates of the current prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers (HCWs) in the departments of Otorinolaryngology and Dentistry and to determine of genes virulence factors (Panton Valentine Leukocidine (PVL) genes). Materials and methods: We performed a multicenter cross-sectional study. The susceptibility to antibiotics was determined by disk diffusion method according to the European Committee on Antimicrobial Susceptibility Testing. The virulence factor encoding genes, mecA, lukS-lukF, were detected by Polymerase Chain Reaction (PCR). Results: Incidence rate of S. aureus nasal carriage among HCWs was 36.2%, whereas MRSA carriage was 17%. Prevalence of MRSA carriage rate was 34.9% in Otorhinolaryngology departments and 9.7% in Dentistry. PCR testing confirmed that all MRSA strains were mecA gene-positive. The virulence factor encoding genes were detected in 82.3% of the S. aureus isolates from HCWs. Among S.aureus, the lukS-lukF genes were detected in over 59% of the strains. The lukS-lukF genes were detected in 55.5% of MRSA and in 58.9% of MSSA strains. LukS-lukF genes were most commonly co-present in MRSA strains. No significant difference was detected between the occurrences of lukS-lukF genes (P > 0.05). Conclusions: Personnell in otorhinolaryngology and dentistry departments have a high rate of nasal colonization of MRSA. This carrier state may be an important risk factor for transmission MRSA from physicians and nurses to patients and vice-versa. Screening for MRSA nasal carriage of HCWs is a key element in enabling infection control measures and early therapeutic decisions.

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