scholarly journals Percutaneous access for the diagnosis of urothelial neoplasms: pictorial essay with anatomopathological correlation

2020 ◽  
Vol 53 (5) ◽  
pp. 345-348
Author(s):  
Thiago Franchi Nunes ◽  
Tiago Kojun Tibana ◽  
Rômulo Florêncio Tristão Santos ◽  
Bernardo Bacelar de Faria ◽  
Vinicius Adami Vayego Fornazari ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Malignant Neoplasm ◽  
High Sensitivity ◽  
Percutaneous Biopsy ◽  
Kidney Tumors ◽  
Image Guided ◽  
Prognostic Groups ◽  
Pictorial Essay ◽  
Urothelial Tumors ◽  
Accuracy Rates

Abstract Urothelial carcinoma is a rare malignant neoplasm, accounting for only 5% to 7% of kidney tumors and 5% of urothelial tumors. During the management of urothelial carcinoma, anatomopathological evaluation is used for stratifying the tumors into different prognostic groups to aid in the evaluation of treatment results and to optimize the management of patients. Percutaneous image-guided biopsy is a safe and feasible procedure, with high sensitivity and accuracy rates. Although image-guided percutaneous biopsy of the urinary tract is a relatively uncommon procedure, it can be considered an option in selected cases or when traditional methods, such as the ureteroscopic technique, are not possible.

scholarly journals Image-guided Percutaneous Drainage in the Pediatric Population: A Primer for Radiologists

2011 ◽  
Vol 1 ◽  
pp. 31 ◽  
Author(s):  
Keerthi Arani ◽  
Kiran Nandalur ◽  
Christina M Tucker ◽  
David A Bloom
Keyword(s):  
Minimally Invasive ◽  
Patient Outcomes ◽  
Percutaneous Drainage ◽  
Pediatric Population ◽  
Infectious Complications ◽  
Image Guided ◽  
Pictorial Essay ◽  
Invasive Method ◽  
Patient Preparation ◽  
The Common

Image-guided percutaneous drainage is an excellent minimally invasive method for dealing with infectious complications in the pediatric population. A thorough understanding of drainage procedures in children can often lead to improved patient outcomes. Indications for percutaneous drainage will be reviewed, including abscesses related to appendicitis, post-surgical abscess formation, and abscesses related to Crohn's disease. This pictorial essay will help the radiologist better understand the common etiologies of abscesses in children that may require percutaneous drainage, the special considerations for catheter placement, patient preparation, and anesthesia or sedation issues unique to the pediatric population.

Image-Guided Percutaneous Biopsy

2011 ◽  
pp. 563-596 ◽  
Author(s):  
Mary S. Newell ◽  
Mary Catherine Mahoney
Keyword(s):  
Percutaneous Biopsy ◽  
Image Guided

Image-Guided Percutaneous Biopsy of Musculoskeletal Lesions

2020 ◽  
pp. 879-885.e1
Author(s):  
Yung-Hsin Chen ◽  
Iman Khodarahmi ◽  
John A. Carrino ◽  
Laura M. Fayad
Keyword(s):  
Percutaneous Biopsy ◽  
Image Guided ◽  
Musculoskeletal Lesions

scholarly journals The Role of Interventional Radiology in the Management of Pancreatic Pathologies

2020 ◽  
Vol 3 (01) ◽  
pp. 099-113
Author(s):  
Ghali Salahia ◽  
Sook Cheng Chin ◽  
Ian Zealley ◽  
Richard D. White
Keyword(s):  
Multidisciplinary Approach ◽  
Irreversible Electroporation ◽  
Vascular Complications ◽  
Percutaneous Biopsy ◽  
Pancreatic Disease ◽  
Percutaneous Radiofrequency Ablation ◽  
Image Guided ◽  
Ablative Techniques ◽  
Effective Diagnosis

AbstractPancreatic pathologies are varied and wide-ranging, and a multidisciplinary approach is essential for effective diagnosis and management. We describe image-guided percutaneous (nonendoscopic) interventions in the management of pancreatic disease, with emphasis on inflammatory and neoplastic pancreatic pathologies and on the transplanted pancreas. Image-guided treatments for the complications of pancreatitis include percutaneous interventions on simple and complex peripancreatic collections, pseudocysts, and fistulas. Vascular interventions predominantly focus on the treatment of pseudoaneurysms, hemorrhagic pseudocysts, and arteriovenous malformations. Emerging ablative techniques for pancreatic cancer are promising and include percutaneous radiofrequency ablation, microwave ablation, irreversible electroporation, and electrochemotherapy. Image-guided interventions on the transplanted pancreas commonly include percutaneous biopsy and drainage in addition to endovascular treatments of vascular complications.

Intratumoral heterogeneity of ERBB2/HER2 expression in micropapillary urothelial carcinoma.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 383-383 ◽  
Author(s):  
Sumit Isharwal ◽  
Hongying Huang ◽  
Gouri Nanjangud ◽  
Francois Audenet ◽  
Yingbei Chen ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Tumor Stage ◽  
Intratumoral Heterogeneity ◽  
Lymph Node Status ◽  
Her2 Overexpression ◽  
Strongly Correlated ◽  
Her2 Expression ◽  
The Status ◽  
Urothelial Tumors ◽  
Erbb2 Amplification

383 Background: Micropapillary urothelial carcinoma (MPUC) is a rare but an aggressive variant of urothelial carcinoma. Histologically, most of these tumors are associated with variable amounts of “not otherwise specified (NOS)” urothelial carcinoma. MPUC has been shown to be associated with ERBB2/HER2 amplification and protein overexpression. However, the status and distribution of these findings within the different components of tumors containing both MP and NOS urothelial carcinoma have not been addressed. Methods: We identified 44 cases of MPUC that had tissue available for FISH and IHC at our institute, of which an NOS component sufficient for both FISH and IHC was identified in 37 cases. We followed the updated ASCO/CAP Guidelines for breast cancer and as such amplification was defined by a HER2/CEP17 ratio of ≥ 2.0 or > 6 copies of the gene and HER2 overexpression was considered with IHC scores of 2+ and 3+. Results: In urothelial tumors with both MP and NOS components (n = 37), ERBB2 amplification in MP and NOS components was present in 25 and 16 cases respectively. ERBB2 amplification was significantly higher in the MP component compared to NOS component within the same tumor (67.57% vs. 43.24%, p = 0.049). HER2 overexpression in MP and NOS components was present in 25 and 13 cases respectively. HER2 overexpression was significantly higher in the MP component compared to NOS component within the same tumor (67.56% vs. 35.13%, p = 0.012). In addition, ERBB2 amplification strongly correlated with HER2 overexpression in both MP (rho = 0.65, p < 0.001) and NOS (rho = 0.74, p < 0.001) components. In this cohort (n = 44), tumor stage and lymph node status were significant predictors for overall survival (p = 0.01, < 0.001 respectively). However, ERBB2 amplification and HER2 overexpression in MP component were not associated with patients’ survival outcome (p = 1.00, 0.75 respectively). Conclusions: In MPUC, ERBB2 amplification and HER2 overexpression were preferentially but not exclusively identified in MP component compared to NOS component within the same tumor. Our findings provide evidence for intratumoral heterogeneity of ERBB2 amplification and HER2 expression in MPUC.

scholarly journals Assessing depression symptoms in those with insomnia: An examination of the Beck Depression Inventory Second Edition (BDI-II)

2021 ◽  
Author(s):  
Colleen Carney ◽  
Christi Ulmer ◽  
Jack D Edinger ◽  
Andrew D Krystal ◽  
Faye Knauss
Keyword(s):  
Beck Depression Inventory ◽  
Roc Curve ◽  
High Sensitivity ◽  
Clinical Interview ◽  
Curve Analysis ◽  
Depression Symptoms ◽  
Roc Curve Analysis ◽  
Clinical Literature ◽  
Item Responses ◽  
Accuracy Rates

Background Due to concerns about overlapping symptomatology between medical conditions and depression, the validity of the Beck Depression Inventory (BDI-II) has been assessed in various medical populations. Although Major Depressive Disorder (MDD) and Primary Insomnia (PI) share some daytime symptoms, the BDI-II has not been evaluated for use with insomnia patients. Method Participants (N = 140) were screened for the presence of insomnia using the Duke Structured Clinical Interview for Sleep Disorders (DSISD), and evaluated for diagnosis of MDD using the Structured Clinical Interview for DSM-IV-TR (SCID). Participants’ mean BDI-II item responses were compared across two groups [insomnia with or without MDD) using multivariate analysis of variance (MANOVA), and the accuracy rates of suggested clinical cutoffs for the BDI-II were evaluated using a Receiver Operating Characteristic (ROC) curve analysis. Results The insomnia with depression group had significantly higher scores on several items; however, the groups did not differ on insomnia, fatigue, concentration problems, irritability, libido, increased appetite, and thoughts relating to suicide, self-criticism and punishment items. The ROC curve analysis revealed moderate accuracy for the BDI-II’s identification of depression in those with insomnia. The suggested BDI cutoff of ≥ 17 had 81% sensitivity and 79% specificity. Use of the mild cutoff for depression (≥14) had high sensitivity (91%) but poor specificity (66%). Conclusion Several items on the BDI-II might reflect sleep disturbance symptoms rather than depression per se. The recommended BDI-II cutoffs in this population have some support but a lower cutoff could result in an overclassification of depression in insomnia patients, a documented problem in the clinical literature. Understanding which items discriminate insomnia patients without depression may help address this nosological issue.

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