scholarly journals Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs

2016 ◽  
Vol 46 (12) ◽  
pp. 2216-2222
Author(s):  
Tiago Barbalho Lima ◽  
Ivan Martinez Padua ◽  
Karina Kamachi Kobashigawa ◽  
Marcela Aldrovani ◽  
Flor Diana Yocoay Claros Chacaltana ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Glycolic Acid ◽  
Treatment Protocol ◽  
Ocular Inflammation ◽  
Intraocular Inflammation ◽  
Acid Copolymer ◽  
Biodegradable Poly ◽  
Pars Plana ◽  
Intravitreal Dexamethasone ◽  
Late Postoperative Period

ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.

scholarly journals Postprocedural Endophthalmitis or Postprocedural Intraocular Inflammation: A Diagnostic Conundrum

2021 ◽  
pp. 418-424
Author(s):  
Aisha Al Busaidi ◽  
Ahmed Al-Hinai
Keyword(s):  
Pars Plana Vitrectomy ◽  
Povidone Iodine ◽  
Complete Recovery ◽  
Neovascular Glaucoma ◽  
Intraocular Inflammation ◽  
Aqueous Samples ◽  
Patient Counseling ◽  
Pars Plana ◽  
Culture Negative ◽  
Office Procedures

We experienced an atypical endophthalmitis occurring post consecutively performed in-office procedures; an intravitreal injection (IVI) of ranibizumab followed by an anterior chamber (AC) paracentesis performed twice in an eye with neovascular glaucoma (NVG). A 52-year-old diabetic male who was asymptomatic developed signs of endophthalmitis and decreased vision without pain in his left eye a few days post-IVI and AC paracentesis. The condition worsened after an initial vitreous tap and injection of antibiotics. Cultures of vitreous and aqueous samples were negative. Complete resolution occurred after a pars plana vitrectomy with IVI of antibiotics and steroid with removal of a dense “yellowish-brown” fibrinous plaque. The absence of pain, presence of a peculiar colored fibrin, mild-to-moderate vitritis without retinitis, negative cultures, and complete recovery despite the fulminant presentation; favor a diagnosis of inflammation over infection. We hypothesize that a micro-leak from a 26-gauge AC tap tract might have served as an entry port for 5% povidone-iodine from the ocular surface thus inciting inflammation. However, an exuberant inflammatory response that can be typically seen in NVG eyes after intraocular procedures cannot be excluded. Various causes of inflammation post-procedures, both toxic and nontoxic should be considered in atypical culture-negative fulminant endophthalmitis cases with good outcome posttreatment. Any minor ocular procedure may carry a risk of such complication. Patient counseling and care must be exercised in performing these procedures.

scholarly journals Capsid-like biodegradable poly-glycolic acid nanoparticles for a long-time release of nucleic acid molecules

2021 ◽  
Author(s):  
Clara Guido ◽  
Mariangela Testini ◽  
Stefania D’Amone ◽  
Barbara Cortese ◽  
Maria Grano ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Glycolic Acid ◽  
Cell Transfection ◽  
Biodegradable Poly ◽  
Long Time ◽  
2D And 3D

Capsid-like PGA nanoparticles (NPs) allow sustained cell transfection in 2D and 3D configurations.

scholarly journals Chronic Glaucoma Using Biodegradable Microspheres to Induce Intraocular Pressure Elevation. Six-Month Follow-Up

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 682
Author(s):  
Maria Jesus Rodrigo ◽  
David Garcia-Herranz ◽  
Manuel Subias ◽  
Teresa Martinez-Rincón ◽  
Silvia Mendez-Martínez ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Clinical Signs ◽  
Progressive Increase ◽  
Biodegradable Microspheres ◽  
Fiber Layer ◽  
Chronic Glaucoma ◽  
Biodegradable Poly ◽  
Contralateral Eye

 Background: To compare two prolonged animal models of glaucoma over 24 weeks of follow-up. A novel pre-trabecular model of chronic glaucoma was achieved by injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (10–20 µm) (Ms20/10) into the ocular anterior chamber to progressively increase ocular hypertension (OHT). Methods: Rat right eyes were injected to induce OHT: 50% received a suspension of Ms20/10 in the anterior chamber at 0, 2, 4, 8, 12, 16 and 20 weeks, and the other 50% received a sclerosing episcleral vein injection biweekly (EPIm). Ophthalmological clinical signs, intraocular pressure (IOP), neuroretinal functionality measured by electroretinography (ERG), and structural analysis of the retina, retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) protocols using optical coherence tomography (OCT) and histological exams were performed. Results: Both models showed progressive neuroretinal degeneration (p < 0.05), and contralateral eye affectation. The Ms20/10 model showed a more progressive increase in IOP and better preservation of ocular surface. Although no statistical differences were found between models, the EPIm showed a tendency to produce thicker retinal and thinner GCL thicknesses, slower latency and smaller amplitude as measured using ERG, and more aggressive disturbances in retinal histology. In both models, while the GCL showed the greatest percentage loss of thickness, the RNFL showed the greatest and earliest rate of thickness loss. Conclusions: The intracameral model with biodegradable microspheres resulted more like the conditions observed in humans. It was obtained by a less-aggressive mechanism, which allows for adequate study of the pathology over longer periods. 

Intraocular pressure changes following 20G pars-plana vitrectomy

2011 ◽  
Vol 90 (8) ◽  
pp. 744-749 ◽  
Author(s):  
Carsten Framme ◽  
Susanne Klotz ◽  
Ute E.K. Wolf-Schnurrbusch ◽  
Peter Wiedemann ◽  
Sebastian Wolf
Keyword(s):  
Intraocular Pressure ◽  
Pars Plana Vitrectomy ◽  
Pars Plana ◽  
Pressure Changes

Synthesis and structure control ofl-lactic acid-glycolic acid copolymer by homo-copolymerization

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Huihui Yin ◽  
Rui Wang ◽  
Huan Ge ◽  
Xiuqin Zhang ◽  
Zhiguo Zhu
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Structure Control ◽  
Acid Copolymer

Unusual presentation of a choroidal melanoma

2021 ◽  
Vol 14 (5) ◽  
pp. e240983
Author(s):  
Sunila Jain ◽  
Kar Yen Phoong
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Pars Plana Vitrectomy ◽  
Visual Loss ◽  
Spindle Cell ◽  
Choroidal Melanoma ◽  
Artificial Eye ◽  
History Of ◽  
Pars Plana ◽  
Eye Clinic

A 49-year-old gentleman presented with a 1-day history of painful deterioration of vision in his right eye. He was lifting heavy weights just before this visual loss. On examination, his vision was perception of light in that eye, with a medically uncontrollable high intraocular pressure and hyphaema almost completely filling his anterior chamber. An ultrasound performed suggested a working diagnosis of a Valsalva related ‘eight ball’ bleed. After an anterior chamber washout, he had another episode of bleeding three days later. A pars plana vitrectomy was performed and the sample obtained was sent off to the laboratory, revealing a choroidal melanoma. Following enucleation, the histology confirmed a large necrotic spindle cell melanoma, with a haemorrhagic background. Fortunately, no liver metastasis was found. Since his diagnosis 3 years ago, he continues to be followed up in an artificial eye clinic and has regular liver scans under the care of his oncologist.

Medical management of silicone oil associated acute postoperative ocular inflammation

2021 ◽  
Vol 14 (7) ◽  
pp. e242251
Author(s):  
Mariya Bashir Doctor ◽  
Deepika Chennapura Parameswarappa ◽  
Padmaja Kumari Rani
Keyword(s):  
Medical Management ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Ocular Inflammation ◽  
Intraocular Inflammation ◽  
Topical Steroids ◽  
Gradual Improvement ◽  
Batch Number ◽  
Oil Injection

We report a case of a 57-year-old man, who underwent right eye silicone oil injection as a part of his surgical treatment for rhegmatogenous retinal detachment. Following this, on the first postoperative day, he developed acute postoperative intraocular inflammation. There was circumciliary congestion, diffuse corneal oedema, anterior chamber (AC) reaction, hypopyon and a pupillary membrane. The AC had not been entered during the surgery. No patients, who had been operated on the same day, or with the materials having the same batch number, developed similar reactions. We started the patient on hourly topical steroids and cycloplegics after which the patient’s condition showed gradual improvement. At the 2 weeks follow-up appointment, his pupillary membrane had completely contracted and the AC was quiet. This case highlights a clinical picture of acute postoperative silicone oil-induced ocular inflammation, which was resolved through medical management.

Experimental Myringoplasty

1980 ◽  
Vol 3 (6) ◽  
pp. 354-357 ◽  
Author(s):  
L. Feenstra ◽  
B.W.C. Van Der Ven ◽  
F.E. Kohn ◽  
J. Feijen
Keyword(s):  
Lactic Acid ◽  
Bisphenol A ◽  
Tympanic Membrane ◽  
Biodegradable Polymers ◽  
Glycolic Acid ◽  
Tissue Reaction ◽  
Biodegradable Poly ◽  
One Year ◽  
Poly Carbonate ◽  
Tympanic Membranes

Artificial eardrums made from biodegradable poly(D, L-lactic acid), poly(glycolic acid) and poly(ß-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a reference subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(ß-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.

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