scholarly journals Intrauterine thrombosis of umbilical artery - case report

2016 ◽  
Vol 134 (4) ◽  
pp. 355-358 ◽  
Author(s):  
Gustavo Henrique de Oliveira ◽  
Cristiane de Moraes Dias ◽  
Denise Cristina Mós Vaz-Oliani ◽  
Antonio Hélio Oliani
Keyword(s):  
Case Report ◽  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Correct Diagnosis ◽  
Perinatal Morbidity ◽  
Mechanical Compression ◽  
Perinatal Complications ◽  
Intrauterine Growth ◽  
High Chance

ABSTRACT: CONTEXT: Umbilical cord thrombosis is related to greater fetal and perinatal morbidity and mortality. It is usually associated with umbilical cord abnormalities that lead to mechanical compression with consequent vascular ectasia. Its correct diagnosis and clinical management remains a challenge that has not yet been resolved. CASE REPORT: This study reports a case of umbilical artery thrombosis that occurred in the second half of a pregnancy. The umbilical cord was long, thin and overly twisted and the fetus presented severe intrauterine growth restriction. The clinical and histopathological findings from this case are described. CONCLUSIONS: This case report emphasizes the difficulty in diagnosing and clinically managing abnormalities of intrauterine life with a high chance of perinatal complications.

scholarly journals Pathophysiological changes of umbilical vessels in intrauterine growth restriction

2014 ◽  
Vol 155 (50) ◽  
pp. 1989-1995
Author(s):  
Mária Jakó ◽  
Andrea Surányi ◽  
László Kaiser ◽  
Dóra Domokos ◽  
Róbert Gáspár ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Perinatal Morbidity ◽  
Control Groups ◽  
Umbilical Vessels ◽  
Intrauterine Growth ◽  
Basal Tone ◽  
Vasopressin Receptors ◽  
And Control

Introduction: The prevalence of intrauterine growth restriction is 4–5000/100,000 births, and they give the majority of perinatal morbidity. Aim: The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies. Method: Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists’ protocol. Results: After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups. Conclusions: The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight. Orv. Hetil., 2014, 155(50), 1989–1995.

Campylobacter coliinfection causing second trimester intrauterine growth restriction (IUGR): a case report and review of the literature

2015 ◽  
Vol 35 (12) ◽  
pp. 1258-1261 ◽  
Author(s):  
Adi Kuperman-Shani ◽  
Zvi Vaknin ◽  
Sonia Mendlovic ◽  
Ronit Zaidenstein ◽  
Yaakov Melcer ◽  
...  
Keyword(s):  
Case Report ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Second Trimester ◽  
Review Of The Literature ◽  
Intrauterine Growth

scholarly journals Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction

2006 ◽  
Vol 163 (11) ◽  
pp. 1035-1041 ◽  
Author(s):  
Laura M. Grosso ◽  
Elizabeth W. Triche ◽  
Kathleen Belanger ◽  
Neal L. Benowitz ◽  
Theodore R. Holford ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Cytochrome P 450

scholarly journals A novel PIK3R1 mutation of SHORT syndrome in a Chinese female with diffuse thyroid disease: a case report and review of literature

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Liying Sun ◽  
Qianwen Zhang ◽  
Qun Li ◽  
Yijun Tang ◽  
Yirou Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Short Stature ◽  
Thyroid Disease ◽  
Nonsense Mutation ◽  
Intrauterine Growth Restriction ◽  
De Novo ◽  
Protein Translation ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Short Syndrome

Abstract Background SHORT syndrome is a rare genetic disease named with the acronyms of short stature, hyper-extensibility of joints, ocular depression, Rieger anomaly and teething delay. It is inherited in an autosomal dominant manner confirmed by the identification of heterozygous mutations in PIK3R1. This study hereby presents a 15-year-old female with intrauterine growth restriction, short stature, teething delay, characteristic facial gestalts who was identified a novel de novo nonsense mutation in PIK3R1. Case presentation The proband was admitted to our department due to irregular menstrual cycle and hirsutism with short stature, who had a history of intrauterine growth restriction and presented with short stature, teething delay, characteristic facial gestalts, hirsutism, and thyroid disease. Whole-exome sequencing and Sanger sequencing revealed c.1960C > T, a novel de novo nonsense mutation, leading to the termination of protein translation (p. Gln654*). Conclusions This is the first case report of SHORT syndrome complicated with thyroid disease in China, identifying a novel de novo heterozygous nonsense mutation in PIK3R1 gene (p. Gln654*). The phenotypes are mildly different from other cases previously described in the literature, in which our patient presents with lipoatrophy, facial feature, and first reported thyroid disease. Thyroid disease may be a new clinical symptom of patients with SHORT syndrome.

scholarly journals Carboxyhemoglobin Levels in Umbilical Cord Blood of Women With Preeclampsia and Intrauterine Growth Restriction

2010 ◽  
Vol 15 (suppl_A) ◽  
pp. 33A-33A
Author(s):  
K Yusuf ◽  
M Kamaluddeen ◽  
E Al-awad ◽  
RA Finch ◽  
B Caron ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Maternal Hematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction

2019 ◽  
Vol 28 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Mária Jakó ◽  
Andrea Surányi ◽  
László Kaizer ◽  
Gábor Németh ◽  
György Bártfai
Keyword(s):  
Platelet Count ◽  
Birth Weight ◽  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Hematological Parameters ◽  
Placental Weight ◽  
Sectional Area ◽  
Cross Sectional ◽  
Intrauterine Growth ◽  
Placental Volume

Objective: To investigate the placental and umbilical cord histopathology in intrauterine growth restriction (IUGR) and their relation to second-trimester maternal hematological parameters. Materials and Methods: Patients were selected for the IUGR group based on estimated fetal weight below the 10th percentile. Patients were recruited into the control group randomly. Patients were followed up with ultrasound, and blood samples were taken between the 20th and 24th gestational weeks. After delivery and formalin fixation, weight and volume of the placenta were recorded and histologic samples were processed. Results: Maternal platelet count strongly correlates with placental weight (r = 0.766). On the other hand, neonatal weight correlates with placental volume (r = 0.572) rather than with placental weight (r = 0.469). Umbilical arterial lumen cross-sectional area correlates with birth weight (r = 0.338). Conclusions: Maternal hematological parameters do not seem to affect neonatal outcome. Our main findings are the correlation of maternal platelet count with placental weight, the correlation of placental volume with birth weight being stronger than the correlation of placental weight with birth weight, and the correlation of umbilical artery lumen cross-sectional area with neonatal weight. Mild histopathologic alterations might occur in normal pregnancies; however, sufficient fetal nutrition can be maintained. This compensatory function of the placenta seems to be insufficient when two or more pathologies are present, which is characteristic for IUGR.

Sign in / Sign up

Export Citation Format

Share Document