Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

2021 ◽  
Vol 64 ◽  
Author(s):  
Mervan Bayraktar ◽  
Omer Shoshin
Keyword(s):  
Growth Traits ◽  
Igf I

Insulin-like growth factor-I measured in juvenile pigs is genetically correlated with economically important performance traits

2005 ◽  
Vol 45 (8) ◽  
pp. 783 ◽  
Author(s):  
K. L. Bunter ◽  
S. Hermesch ◽  
B. G. Luxford ◽  
H-U. Graser ◽  
R. E. Crump
Keyword(s):  
Growth Factor ◽  
Growth Traits ◽  
Genetic Correlations ◽  
Selection Criterion ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Performance Traits ◽  
Growth Factor I ◽  
Daily Gain

Insulin-like growth factor-I (IGF-I) is a naturally occurring polypeptide produced in the liver, muscle and fat tissues. It is known to be associated with growth and development during the postnatal growth period. Evidence for strong genetic correlations between juvenile IGF-I and performance traits would suggest this physiological measure would be useful as an early selection criterion. This paper reports estimates of genetic parameters from 9 trials where IGF-I was measured in juvenile pigs. All trials involved populations undergoing active selection for improved performance (e.g. efficient lean meat growth). Juvenile IGF-I was moderately heritable (average h2: 0.31) and influenced by common litter effects (average c2: 0.15). Genetic correlations (rg) between juvenile IGF-I and backfat (BF), feed intake (FI) or feed conversion ratio (FCR) traits were generally large and positive: rg averaged 0.57, 0.41 and 0.65, respectively. Phenotypic correlations (rp) between juvenile IGF-I and BF, FI or FCR were much lower (rp averaged 0.21, 0.09, and 0.15, respectively) as residual correlations between IGF-I and these performance traits were low, consistent with being measured at very different times. Correlations (genetic or phenotypic) between juvenile IGF-I and growth traits (e.g. lifetime daily gain or test daily gain) were relatively low, with average values within ± 0.09 of zero. Results from the trials reported here, and several physiological studies, indicate that information on juvenile IGF-I concentration can be used as an early physiological indicator of performance traits traditionally measured later in life. There is a clear role for juvenile IGF-I to facilitate pre-selection and more accurate selection of livestock for hard to measure traits, such as FCR, in pig breeding programs.

scholarly journals PCR-SSCP Variation of IGF1 and PIT1 Genes and Their Association with Estimated Breeding Values of Growth Traits in Makooei Sheep

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Negahdary ◽  
Abbas Hajihosseinlo ◽  
Marziyeh Ajdary
Keyword(s):  
Metabolic Pathways ◽  
Growth Traits ◽  
Genome Mapping ◽  
Banding Patterns ◽  
Breeding Values ◽  
Igf I ◽  
Puberty Stages ◽  
Estimated Breeding Values ◽  
Mapping Information

Molecular biology techniques genetic improvement by facilitating identification, mapping and analysis of polymorphism of genes by encoding proteins that act on metabolic pathways involved in economically interesting traits. This use of genetic markers can aid identification of those animals with the highest breeding values in sheep. On the basis of sheep genome mapping, information was examined on the ovine IGF1 and PIT1 genes as a possible genetic marker for growth traits in sheep. The current study was designed to estimate the frequencies of putative IGF-1 and PIT-1 genes SNPs and investigate associations with calculated EBVs of growth traits in Makooei sheep. PCR-SSCP analysis of the exon1 of IGF-I gene and include a part of intron2, exon3 and a part of intron3 and PIT-1 gene revealed the following banding patterns; three (AA, AG, GG) and four AA (p1), AB (p2), CC (p3), CD (p4), banding patterns respectively. Results from this study demonstrated higher performance of AA animals in BW and GBW, and AG animal in WW and W6 that may be related to the role of IGF-1 at the pre-puberty and puberty stages. Also higher performance of p3 animals in W9, YW and GSN, and p1 animal in GNY may be related to the PIT-1 role in post-puberty.

scholarly journals Evaluation of Polymorphism in IGF-I and IGFB-3 Genes and their Relationship tith Twinning Rate and Growth Traits in Markhoz Goats

2017 ◽  
Vol 17 (1) ◽  
pp. 89-103 ◽  
Author(s):  
Sahar Rasouli ◽  
Alireza Abdolmohammadi ◽  
Alireza Zebarjadi ◽  
Ali Mostafaei
Keyword(s):  
Growth Factor ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Insulin Like Growth Factor ◽  
Economic Traits ◽  
Chi Square ◽  
Genotype Frequencies ◽  
Igf I ◽  
I Gene ◽  
Igfbp 3

AbstractGrowth rate and twinning rate are economic traits that can be used in goat breeding objectives. The aim of this study was to investigate polymorphisms in the insulin-like growth factor 1(IGF-I) and insulin-like growth factor binding protein (IGFBP-3) genes and their relationship with growth traits and twinning in Markhoz goats. Two sets of specific primers were used to amplify a 249bp fragment of IGF-I gene and a 316bp fragment of IGFBP-3 gene. PCR-SSCP analysis revealed three banding patterns for each gene that confirmed presence of a mutation in position 1617 of the IGF-I gene and a mutation in position 58 of IGFBP-3 gene. The genotype frequencies of IGF-I gene were 0.81 (GG), 0.16 (GA) and 0.03 (AA). Also, the genotype frequencies of IGFBP-3 gene were 0.79 (TT), 0.17 (TC) and 0.04 (CC). The Odds Ratio estimated for twinning rate was 1.11 for second on first parity, 0.19 for third on first parity and 5.71 for second on third parity. The chi-square statistics were 6.46 for IGF-I gene and 3.32 for IGFBP-3 gene. The results also indicated that different genotypes of these genes had no significant effect on birth weight, weight at 6 months, at 9 months and at 12 months but the interactions between different genotypes of IGF-I and IGFBP-3 genes were significant for weaning weight and average daily gain from birth to weaning. These results suggest that twinning rate in Markhoz breed is statistically affected by these genes and can be considered in breeding programs.

Polymorphism of Insulin-Like Growth Factor I Gene among Chicken Breeds in Egypt

2010 ◽  
Vol 65 (3-4) ◽  
pp. 284-288 ◽  
Author(s):  
Eman M. Gouda ◽  
Gamal S. Essawy
Keyword(s):  
Growth Factor ◽  
Growth Traits ◽  
Sscp Analysis ◽  
Insulin Like Growth Factor ◽  
Rt Pcr ◽  
Factor I ◽  
Igf I ◽  
Pcr Products ◽  
Growth Factor I ◽  
I Gene

The insulin-like growth factor I (IGF-I) regulates growth, protein synthesis, and cell proliferation and differentiation in vertebrates. Polymorphisms of IGF-I gene transcripts of three breeds of chicken were assessed. The associations of these polymorphisms with the growth rate of the studied breeds were also evaluated. Total RNA was isolated from chicken livers, and the IGF-I gene was amplified from each breed RNA by RT-PCR using specific primers flanking a certain region of the gene. The amplified RT-PCR products were formed to identify the transcripts and to correlate them to the phenotype of growth, by performing single stranded conformation polymorphism (SSCP) analysis for genotype identification. In this report, we describe how SSCP analysis of RT-PCR products can be used to evaluate the transcript expression pattern of avian IGF-I polymorphism, and their effect on the growth traits of chickens.

scholarly journals A New Single Nucleotide Polymorphism in the IGF-I Gene and Its Association with Growth Traits in the Nanjiang Huang Goat

2008 ◽  
Vol 21 (8) ◽  
pp. 1073-1079 ◽  
Author(s):  
Chunxiang Zhang ◽  
Wei Zhang ◽  
Hailing Luo ◽  
Wenbin Yue ◽  
Mingyu Gao ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Growth Traits ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Igf I ◽  
I Gene

Genetic and phenotypic relationships between insulin-like growth factor-I (IGF-I) and net feed intake, fat, and growth traits in Angus beef cattle

2005 ◽  
Vol 56 (3) ◽  
pp. 211 ◽  
Author(s):  
K. L. Moore ◽  
D. J. Johnston ◽  
H-U. Graser ◽  
R. Herd
Keyword(s):  
Growth Factor ◽  
Beef Cattle ◽  
Genetic Correlation ◽  
Feed Intake ◽  
Growth Traits ◽  
Genetic Correlations ◽  
Production Traits ◽  
Factor I ◽  
Phenotypic Correlations ◽  
Igf I

Insulin-like growth factor-I (IGF-I) concentration measured in the blood plasma of 6520 seedstock Angus beef cattle (3622 bulls and 2898 heifers) from eastern Australia between 2002 and 2004 was used to estimate the heritability of IGF-I and phenotypic and genetic correlations with net feed intake (NFI) and other production traits. The average concentration of IGF-I was 314 ng/mL measured at the average age of 242 days. A moderate heritability of 0.35 was estimated for IGF-I. IGF-I was further defined as being measured either at, or prior to, weaning (average age of 201 days) or post-weaning (average age 310 days). The genetic correlation between IGF-I recorded at the different ages was 1.0 ± 0.04. IGF-I and NFI were found to have a genetic correlation of 0.41 ± 0.21. IGF-I had positive genetic correlations of 0.22 ± 0.14, 0.19 ± 0.14, and 0.26 ± 0.15 with ultrasound-scanned subcutaneous fat depth at the rump (P8) and 12/13th rib (RIB) sites and intramuscular fat % (IMF), respectively. Corresponding phenotypic correlations were 0.14, 0.13, and 0.12, respectively, for P8, RIB, and IMF. IGF-I had low to moderate negative genetic correlations with growth traits. Direct genetic correlations for IGF-I of –0.22 ± 0.08, –0.17 ± 0.09 and –0.10 ± 0.14 were estimated with birth (BWT), 200-day (WT200), and 400-day (WT400) weights, respectively. Genetic correlations between the direct component of IGF-I and maternal components of BWT and WT200 were 0.15 ± 0.13 and 0.31 ± 0.11, respectively. Phenotypic correlations of the direct component of IGF-I with the direct components of BWT, WT200, and WT400 were –0.10, 0.06, and 0.16, respectively. Ultrasound-scanned eye muscle area (EMA) and IGF-I had genetic and phenotypic correlations of –0.22 ± 0.15 and 0.13, respectively. This study showed that IGF-I is heritable and genetically correlated with important production traits. The genetic correlations indicate that selection for lower IGF-I concentrations would result in cattle that have lower NFI (i.e. more feed efficient), are leaner, with increased growth, and possibly decreased maternal weaning weight.

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