scholarly journals -866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis

2020 ◽  
Vol 43 (2) ◽  
Author(s):  
Cristine Dieter ◽  
Taís Silveira Assmann ◽  
Natália Emerim Lemos ◽  
Eloísa Toscan Massignam ◽  
Bianca Marmontel de Souza ◽  
...  
2018 ◽  
Vol 56 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Taís S. Assmann ◽  
Mariana Recamonde-Mendoza ◽  
Aline R. Costa ◽  
Márcia Puñales ◽  
Balduíno Tschiedel ◽  
...  

2017 ◽  
Vol 131 (15) ◽  
pp. 1815-1829 ◽  
Author(s):  
Chia-Chu Chang ◽  
Chen-Yu Chen ◽  
Ching-Hui Huang ◽  
Chia-Lin Wu ◽  
Hung-Ming Wu ◽  
...  

Advanced glycation end-products (AGEs) form during oxidative stress, which is increased in diabetes mellitus (DM). Uromodulin is a protein with a renal protective effect, and may be subject to glycation. The implications of uromodulin glycation and AGEs in the urine are not understood. Here, immunoprecipitation and liquid chromatography–mass spectrometry identified glycated uromodulin (glcUMOD) in the urine of 62.5% of patients with diabetic kidney disease (DKD), 20.0% of patients with non-diabetic chronic kidney disease (CKD), and no DM patients with normal renal function or healthy control participants; a finding replicated in a larger cohort of 84 patients with CKD in a case–control study (35 with DM, 49 without). Uromodulin forms high molecular weight polymers that associate with microvesicles and exosomes. Differential centrifugation identified uromodulin in the supernatant, microvesicles, and exosomes of the urine of healthy participants, but only in the supernatant of samples from patients with DKD, suggesting that glycation influences uromodulin function. Finally, the diagnostic and prognostic utility of measuring urinary glcUMOD concentration was examined. Urinary glcUMOD concentration was substantially higher in DKD patients than non-diabetic CKD patients. Urinary glcUMOD concentration predicted DKD status, particularly in patients with CKD stages 1–3a aged <65 years and with urine glcUMOD concentration ≥9,000 arbitrary units (AU). Urinary uromodulin is apparently glycated in DKD and forms AGEs, and glcUMOD may serve as a biomarker for DKD.


2014 ◽  
Author(s):  
Bianca Souza ◽  
Leticia Brondani ◽  
Tais Assmann ◽  
Ana Paula Boucas ◽  
Andrea Carla Bauer ◽  
...  

Author(s):  
Kok Yeow Phneh ◽  
Eric Tzyy Jiann Chong ◽  
Syahiskandar Sybil Shah ◽  
Yuen Kang Chia ◽  
Dayang Maryama Bte Awang Daud ◽  
...  

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