Chemical constituents of Pseudobrickellia brasiliensis leaves(Spreng.) R.M. King & H. Rob. (Asteraceae)

ABSTRACT Pseudobrickelliabrasiliensisis aspecies endemic toBrazil, popularlyknown as “arnica”/ “arnica-do-campo”/ “arnica-do-mato” and used for itsanalgesicand anti-inflammatoryproperties. The objective of this research was thephytochemical studyof the essential oilandhexaneandethyl acetateextracts of the leaves of this species. The essential oilwasextracted byhydrodistillation using a Clevengerapparatusand was analyzed byGC/MS, 25components were identified, with a predominance ofmonoterpenes. The extractswere subjected toclassicalchromatographyand the fractionswere analyzed byGC/MS, 1D 1H-NMR, 13C-NMR and 13C-NMR-DEPT 135.α-amyrin, α-amyrin acetate, β-amyrin, β-amyrin acetate, lupeol, lupeolacetate, pseudotaraxasterol andtaraxasterol (triterpenes), andkaurenoicacid (diterpene) were identified.Theseterpenesarechemo-taxonomicallyrelated to theEupatorieaetribe(Asteraceae) and may be responsible for the anti-inflammatory activity attributed to the plant.

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Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v12i12.4826 ◽

2016 ◽

Vol 12 (12) ◽

pp. 4557-4563

Author(s):

Dhinesh kumar Manoharan

Keyword(s):

1H Nmr ◽

13C Nmr ◽

Protein Denaturation ◽

Inflammatory Activity ◽

Potent Inhibition ◽

Ft Ir ◽

Anti Inflammatory

Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation

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Synthesis, Characterization and Anti-inflammatory Activity of (2E)-3-(2-Bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-one

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22421 ◽

2020 ◽

Vol 32 (3) ◽

pp. 561-564

Author(s):

Dileep Kumar M. Guruswamy ◽

Shankar Jayarama

Keyword(s):

1H Nmr ◽

13C Nmr ◽

Stair Climbing ◽

Inflammatory Activity ◽

Spectral Studies ◽

Albino Rats ◽

Paw Edema ◽

Standard Drug ◽

Edema Model ◽

Anti Inflammatory

(2E)-3-(2-Bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl)prop-2-en-1-one (d1) was synthesized by the Claisen-Schmidt condensation method and characterized by 1H NMR, 13C NMR spectral studies. The anti-inflammatory activity was conducted in Swiss albino rats for paw edema model. Edema was actuated with 1 % carrageenan to every one of the animals following 1 h of the oral medicines. Paw thickness was checked at t = 1, 2, 3, 4, 5 and 24 h. Stair climbing score and motility score were surveyed at t = 24 h. Compound d1 signicant decline in paw thickness at p < 0.001 diminished by 32 % in paw thickness. The compound d1 signicantly expanded the stair climbing and motility score. This study suggested that the compound d1 exhibits remarkable anti-inflammatory activity when compared with that of the standard drug.

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Novel Heterocyclic Hybrids Based on 2-Pyrazoline: Synthesis and Assessment of Anti-Inflammatory and Analgesic Activities

Current Organic Synthesis ◽

10.2174/1570179416666190703115133 ◽

2019 ◽

Vol 16 (6) ◽

pp. 921-930 ◽

Cited By ~ 1

Author(s):

Ahmed A.O. Abeed ◽

Gehad A.A. Jaleel ◽

Mohamed S.K. Youssef

Keyword(s):

Acute Toxicity ◽

1H Nmr ◽

13C Nmr ◽

High Performance ◽

Nmr Spectra ◽

Chemical Shifts ◽

Coupling Constants ◽

Inflammatory Activity ◽

Necrosis Factor Alpha ◽

Anti Inflammatory

Aim and Objective: A series of new 2-pyrazoline analogues were synthesized. The structures of the synthesized compounds were elucidated by the analytical and spectroscopic data. Some selected compounds were screened for the anti-inflammatory activity by using animal model of carrageenan-induced paw edema in mice. Additionally, the analgesic and acute toxicity of these compounds were evaluated and exhibited reasonable results. The anti-oxidant and anti-inflammatory effects of these compounds were established by measuring the contents of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), and tumor necrosis factor alpha (TNF-α) in the edema paw tissue. Materials and Methods: All chemicals and reagents used in current study were of analytical grade. Melting points were determined using APP. Digital ST 15 melting point apparatus and are uncorrected. FT-IR spectra were recorded on a Pye-Unicam SP3-100 spectrophotometer in KBr pellet. All 1H and 13C NMR spectra were recorded on AVANCE-III (400 MHz) High Performance FT-NMR Spectrometer Brucker (Switzerland) and some 1H NMR spectra were recorded on Varian EM-360L NMR Spectrophotometer (60 MHz) (USA) in CDCl3 or DMSO-d6 as solvent. Chemical shifts are reported in δ units and the coupling constants (J) are reported in hertz. C, H, N and S analyses were performed with a Vario EL C, H, N, S Analyzer. Carrageenan (product number C1013) was obtained from Sigma-Aldrich (USA). Results: The structures of the compounds were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses. The results of pharmacological activity revealed that compounds 5, 6, 7, and 15 could be recognized as potential multi-potent anti-inflammatory. Conclusion: A simple and suitable method for the synthesis of new pharmacophore was reported. We have designed nineteen heterocycles related to pyrazoline ring, and evaluated eleven of them for their antiinflammatory, analgesic and acute toxicity activities. Compounds 5, 6, 7, and 15 proved to be the interesting compounds, they have high anti-inflammatory activity. However, all the selected compounds show remarkable analgesic activity.

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Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.01.009 ◽

2014 ◽

Vol 22 (5) ◽

pp. 1766-1772 ◽

Cited By ~ 18

Author(s):

Yuan-Siao Chen ◽

Hui-Ming Yu ◽

Jiun-Jie Shie ◽

Ting-Jen Rachel Cheng ◽

Chung-Yi Wu ◽

...

Keyword(s):

Chemical Constituents ◽

Inflammatory Activity ◽

Synthetic Analogs ◽

Anti Inflammatory ◽

Plectranthus Amboinicus

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SYNTHESIS AND EVALUATION OF SOME NOVEL TRIAZOLO BETA-LACTAM DERIVATIVES FOR THEIR ANTI-INFLAMMATORY ACTIVITY

INDIAN DRUGS ◽

10.53879/id.51.01.p0048 ◽

2014 ◽

Vol 51 (01) ◽

pp. 48-54

Author(s):

◽

N.B Wable ◽

D.S Musmade ◽

V. B. Gawali ◽

J. S. Pattan ◽

...

Keyword(s):

1H Nmr ◽

Inflammatory Activity ◽

Beta Lactam ◽

Standard Drug ◽

Anti Inflammatory

A series of substituted triazole based β-Lactam derivatives were synthesized. The structures of the synthesized compounds were characterized and confirmed by IR, 1H- NMR and CHN analysis. The synthesized compounds were evaluated for their anti-inflammatory activity. All the compounds have shown promising anti-inflammatory activity when compared with standard drug Ibuprofen.

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Chemical Constituents from Farfugium Japonicum Var. formosanum

Natural Product Communications ◽

10.1177/1934578x1200700405 ◽

2012 ◽

Vol 7 (4) ◽

pp. 1934578X1200700 ◽

Cited By ~ 1

Author(s):

Sung-Fei Hsieh ◽

Tain-Jye Hsieh ◽

Mohamed El-Shazly ◽

Ying-Chi Du ◽

Chin-Chung Wu ◽

...

Keyword(s):

Chemical Constituents ◽

Cancer Cell Line ◽

Inflammatory Activity ◽

Human Neutrophils ◽

Spectral Techniques ◽

Methanolic Extracts ◽

Aerial Parts ◽

Anti Inflammatory ◽

Farfugium Japonicum ◽

First Time

Two new eremophilenolides, 6β8β10β-trihydroxyeremophil-7(11)-en-12,8-olide (1) and 3βacetoxy-8α-hydroxy-6β-methoxyeremophila-7(11),9-dien-12,8-olide (2) along with twenty-nine other compounds were obtained from the methanolic extracts of the aerial parts and rhizomes of Farfugium japonicum (L.) Kitam. v ar. formosanum (Hayata) Kitam. (Compositae = Asteraceae). The structures of the isolated compounds were characterized and identified by spectral techniques. Compounds 5, 6, 10, 12-24, 29, and 30, were reported for the first time from this genus. Cytotoxicity and anti-inflammatory activity of the isolated compounds were evaluated. Compounds 3 and 16 possessed moderate cytotoxicity against human breast cancer cell line (MCF 7). Compounds 3, 16, 25 and 26 exhibited moderate cytotoxicity against hepatoma cells (Hep G2 and Hep 3B). With respect to the anti-inflammatory activity, compounds 15 and 16 (each 10 μg/mL) inhibited superoxide anion generation by human neutrophils in response to fMLP/CB by 92.0% and 87.3%, respectively.

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