scholarly journals Cardioprotection stimulated by resveratrol and grape products prevents lethal cardiac arrhythmias in an animal model of ischemia and reperfusion

2021 ◽  
Vol 36 (3) ◽  
Author(s):  
Francisco Sandro Menezes-Rodrigues ◽  
Paolo Ruggero Errante ◽  
Erisvaldo Amarante Araújo ◽  
Mariana Pontes Pacheco Fernandes ◽  
Michele Mendes da Silva ◽  
...  
Keyword(s):  
Animal Model ◽  
Cardiac Arrhythmias ◽  
Ischemia And Reperfusion

scholarly journals The Diabetic Heart: Too Sweet for Its Own Good?

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Hannah J. Whittington ◽  
Girish G. Babu ◽  
Mihaela M. Mocanu ◽  
Derek M. Yellon ◽  
Derek J. Hausenloy
Keyword(s):  
Diabetes Mellitus ◽  
Animal Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Experimental Models ◽  
Diabetic Heart ◽  
Ischemia And Reperfusion ◽  
Ischemic Conditioning ◽  
Animal Data ◽  
Patients With Diabetes

Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast, the animal data suggests that the diabetic heart may be either more, equally, or even less susceptible to IRI. The conflicting animal data may be due to the choice of diabetic and/or IRI animal model. Ischemic conditioning, a phenomenon in which the heart is protected against IRI by one or more brief nonlethal periods of ischemia and reperfusion, may provide a novel cardioprotective strategy for the diabetic heart. Whether the diabetic heart is amenable to ischemic conditioning remains to be determined using relevant animal models of IRI and/or diabetes. In this paper, we review the limitations of the current experimental models used to investigate IRI and cardioprotection in the diabetic heart.

First Prize: Isoprostane: Quantitation of Renal Ischemia and Reperfusion Injury After Renal Artery Clamping in an Animal Model

2012 ◽  
Vol 26 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Zijun Wang ◽  
Janet L. Colli ◽  
Christopher Keel ◽  
Kayleen Bailey ◽  
Leah Grossman ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Artery ◽  
Reperfusion Injury ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

A direct role of endogenous prostaglandins in reperfusion-induced cardiac arrhythmias

1989 ◽  
Vol 67 (7) ◽  
pp. 772-779 ◽  
Author(s):  
Margaret P. Moffat ◽  
Gregory R. Ferrier ◽  
Morris Karmazyn
Keyword(s):  
Cardiac Arrhythmias ◽  
Ischemia Reperfusion ◽  
Ischemia And Reperfusion ◽  
Early Repolarization ◽  
Direct Role ◽  
Purkinje Fibres ◽  
Endogenous Prostaglandins ◽  
Pg Release

The possible role of prostaglandins (PG) in arrhythmias associated with ischemia and reperfusion was studied in isolated, superfused canine Purkinje tissues. Ischemic conditions caused partial depolarization and decrease of excitability. Neither inhibition of PG synthesis (ibuprofen, 30 μg/mL) nor addition of exogenous PGF2α (1 ng/mL) modified responses to "ischemia." Reperfusion with normal Tyrode's solution stimulated PG production (measured as 6-keto-PGF1α) and induced a series of electrophysiological events. Under control conditions, Purkinje fibres rapidly repolarized. Subsequently, these tissues began to depolarize and oscillatory afterpotentials appeared. Purkinje tissues depolarized further and became temporarily inexcitable. Return of activity was associated with depolarization-induced automaticity. Ibuprofen prevented reperfusion-stimulated PG release. Ibuprofen also increased the magnitude of early repolarization and greatly attenuated subsequent depolarization. Depolarization-induced automaticity was not observed under these conditions; however, oscillatory afterpotentials were not abolished by ibuprofen. Addition of PGF2α to "ischemic" and reperfusion solutions in the presence of ibuprofen restored the arrhythmogenic responses. We conclude that release of endogenous prostaglandins contributes to electrophysiological changes elicited by reperfusion in canine Purkinje fibres.Key words: arrhythmias, ischemia, reperfusion, ibuprofen, prostaglandins.

scholarly journals Effects of Palmitoylethanolamide and Silymarin Combination Therapy in an Animal Model of Kidney Ischemia and Reperfusion

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Giuseppe Bruschetta ◽  
Daniela Impellizzeri ◽  
Rosalba Siracusa ◽  
Rosanna Di Paola ◽  
Irene Paterniti ◽  
...  
Keyword(s):  
Animal Model ◽  
Combination Therapy ◽  
Ischemia And Reperfusion ◽  
Kidney Ischemia

Critical Brain Injury in Hypoxia-Ischemia and Reperfusion-Reoxygenation in an Animal Model of Cerebral Palsy

2010 ◽  
Vol 49 ◽  
pp. S158-S159
Author(s):  
Sidhartha Tan ◽  
Lei Yu ◽  
Alexander Drobyshevsky ◽  
Matthew Derrick ◽  
Kehuan Luo ◽  
...  
Keyword(s):  
Animal Model ◽  
Cerebral Palsy ◽  
Brain Injury ◽  
Ischemia And Reperfusion ◽  
Hypoxia Ischemia
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