Microvascular reactivity in type 1 diabetics

OBJECTIVE: To evaluate whether differences are present in microvascular response to the schemia induced by dynamic videocapillaroscopy (VCD), through analysis of the measured capillar transverse segment area (CTSA) in patients with type 1 diabetes mellitus (T1DM). METHODS: The vascular reactivity of the CTSA was studied by VCD, using a reactive hyperemia test in 61 volunteers, being 31 healthy controls without diabetes family history (Group 1) and 30 patients with T1DM without complications (Group 2). The images were captured every two seconds, during reperfusion after one minute induced ischaemia, and they were analyzed by the program Studio Version 8 and Motic Image Plus. The pre-ischemia capillary transverse segment (basal area, BA), the maximum strain post-ischemia (maximum area, MA), and time to achieve it (MAt) were measured during reperfusion, and the increased area percentage (Ap) was estimated. RESULTS: The mean differences between groups were evaluated by the t-test. The median comparisons between the groups were studied by the Mann-Whitney test. There was no difference in BA between the groups. The Ap was significantly lower among the diabetic patients, and there was a significant increase in the Mat among the patients of Group 2 when compared to Group 1. CONCLUSIONS: These data suggest that type 1 diabetes provokes earlier endothelial dysfunction, before the onset of clinically detectable degenerative complications. The outcomes from these alterations need further studies.

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THE EFFECT OF CONTINUOUS SUBCUTANEOUS INSULIN INFUSION TREATMENT, INSULIN ANALOG, AND HUMAN INSULIN OF CHILDREN WITH DIABETES

CBU International Conference Proceedings ◽

10.12955/cbup.v3.634 ◽

2015 ◽

Vol 3 ◽

pp. 432-436

Author(s):

Elina Petkova ◽

Valentina Petkova ◽

Guenka Petrova ◽

Maya Konstantinova

Keyword(s):

Type 1 Diabetes ◽

Cost Effectiveness ◽

Human Insulin ◽

Continuous Subcutaneous Insulin Infusion ◽

Insulin Infusion ◽

Subcutaneous Insulin ◽

Group 3 ◽

Group 2 ◽

Group 1

The aim of this study is to evaluate the cost-effectiveness of continuous subcutaneous insulin infusion (CSII) to multiple daily insulin injection (MDI) either with analogues or with human insulin, based on the achieved therapeutic results such as changes in glycated hemoglobin level (HbA1c) in the various therapies. The study was performed with children with type-1 diabetes in Bulgaria. The objective of this study was to serve for the Bulgarian National Health Fund (NHIF).Methods: A combined retrospective and prospective study was performed at the Endocrinology diabetes and genetic diseases clinic.51 children with type-1 diabetes were observed for 7 months diveded into three group: Group 1- on continuous subcutaneous insulin infusion (CSII); Group 2- on multiple daily insulin analogues injections (MDI) and Group 3 – on human insulin (HI).Patient demographic data, age, sex, weight, duration of disease, HbA1c – values before the start of the study and after the end of the observation and type of treatment (CSII; MDI or HI) were observed. Cost-effectiveness, sensitivity and statistical analyses are applied to studied long-term therapeutic results.Results: The three groups of observed children do not differ statistically in age and gender. Most of the participants in Group 1 and Group 2 have suffered from diabetes from 5,6 years. The duration of diabetes was lower in the group of human insulin. All studied children are treated. By all of them the results of the treatment improved, but in the Group 1 the improvement of HbA1c is the highest. The average improvement of HbA1c in the Group 1 after the CSII introduction is 1.85, while after the application of analogue insulin is 0,59 and 0,28 respectively in the Group 3 after the treatment on human insulin.The cost of insulin pump, consumables- infusion set and insulin reservoir, blood glucose monitoring system, strips, needles and insulin cost was calculated.The total cost ot the treatment of diabetes with insulin pump for 7 months is 2358,85Euro; 856,98 Euro in the Group 2 on MDI and 744,24 Euro for 7 months in the Group 3 on human insulin.The differences in costs and therapeutic results permit to conduct cost- effectiveness analysis by comparing of the three alternatives.Our study shows that the CSII pumps allows better diabetes control compared to the treatment with analogue insulin and human insulin. Insulin pumps are also cost- effectiveness alternative for children with type 1 diabetes.

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Impact of glycemic variability and the fear of hypoglycemia on type 1 diabetes control

Russian Medical Inquiry ◽

10.32364/2587-6821-2020-4-6-324-328 ◽

2020 ◽

Vol 4 (6) ◽

pp. 324-328

Author(s):

A.R. Volkova ◽

◽

M.E. Chernaya ◽

V.S. Mozgunova ◽

M.B. Durdyeva ◽

...

Keyword(s):

Type 1 Diabetes ◽

Glycemic Variability ◽

Diabetes Control ◽

Target Level ◽

Fear Of Hypoglycemia ◽

Group 2 ◽

Hba1c Target ◽

Hba1c Levels ◽

Group 1

Background: currently, the level of HbA1c does not necessarily allow for the understanding of glycemic control. Considering this, glycemic variability (GV) is extensively studied in recent years. Psychological component has a significant impact on GV as the fear of hypoglycemia (FOH) and its consequences can reduce the motivation for achieving target glycemia and HbA1c as well as adherence to treatment.Aim: to assess GV in patients with type 1 diabetes with the elevated and target levels of HbA1c and to analyze the effect of FOH on diabetes control.Patients and Methods: 78 patients with type 1 diabetes who received insulin therapy (multiple daily injections or continuous subcutaneous insulin infusion) were enrolled. All patients were divided into two groups based on HbA1c levels, i.e., group 1 (patients who achieved individual HbA1c target level, n=13) and group 2 (patients who did not achieve individual HbA1c target level, n=65). HbA1c levels and GV were measured in all patients using iPRO™2 Professional CGM system (Medtronic, Ireland). In addition, FOH was evaluated using the Hypoglycemia Fear Survey II (HFS-II).Results: in group 1, time in-range was significantly higher (p=0.013) while daily GV was significantly lower (p=0.023) than in group 2. HbA1c levels, the rate of severe hypoglycemia, and diabetes duration were lower among the patients with lower levels of FOH.Conclusion: studying GV can provide better understanding of diabetes control in patients with any HbA1c level. Optimized treatment strategy using HFS-II can attenuate the effects of frequent hypoglycemia on GV and HbA1c levels and improve treatment efficacy.KEYWORDS: glycemic variability, glycated hemoglobin, diabetes, continuous glucose monitoring, hypoglycemia.FOR CITATION: Volkova A.R., Chernaya M.E., Mozgunova V.S. et al. Impact of glycemic variability and the fear of hypoglycemia on type 1 diabetes control. Russian Medical Inquiry. 2020;4(6):324–328. DOI: 10.32364/2587-6821-2020-4-6-324-328.

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Analysis of indicators of daily blood pressure profile in patients wi th type 1 diabetes, depending on the course of the disease

Endokrynologia ◽

10.31793/1680-1466.2018.23-4.301 ◽

2018 ◽

Vol 23 (4) ◽

pp. 301-308

Author(s):

N.O. Pertseva ◽

K.I. Moshenets

Keyword(s):

Blood Pressure ◽

Type 1 Diabetes ◽

Pressure Profile ◽

Healthy Controls ◽

Area Index ◽

Time Index ◽

Blood Pressure Profile ◽

Group 2 ◽

Group 1

The aim: to study the features of daily profile and circadian rhythm of blood pressure (BP) in groups of patients with type 1 diabetes mellitus (T1DM), depending on glycemic control. Materials and methods: 63 patients with T1DM, age: 18-45 years without hypertension were examined. Patients were divided into groups: Group 1 — HbA1c≤7.0% (n=21), Group 2 — HbA1c>7.0% (n=42). 10 sex- and agematched healthy controls were included. Results: Patients with T1DM had a significantly higher pulsatile blood pressure (PBP) per night, higher daily systolic blood pressure (SBP) variability, compared with healthy controls, and significantly higher daily SBP area index (SPAI24), daily SBP time index (SPTI24), daily diastolic blood pressure (DBP) area index (DPAI24), daily DBP time index (DPTI24). The double product (DP) was higher in patients with T1DM in the daytime and within 24 hours compared to control (p=0.002) and (p=0.001) respectively. Pathological profiles of daily blood pressure were found. In group 1, according to the dipping in SBP 28.57% of patients were non-dippers, 4.76% were extreme dippers. In group 2, the non-dipper profile had 33.33%, the reverse dipper had 2.38%, and extreme dipper had 11.90% of patients. According to the dipping in DBP: in group 1 33.33% were non-dippers, and 9.53% were extreme dippers. In group 2 non-dippers — 19.04%, extreme dippers — 2.38%, extreme dippers — 38.10%. HbA1c directly correlates with: (DPAI24) (ρ=0,301; р=0,014), DPAI night (ρ=0,292; р=0,010), DPTI24 (ρ=0.292; p=0.012), DPTI night (ρ=0.268; p=0.018). Conclusions. The daily blood pressure profile in patients with T1DM without arterial hypertension is characterized by insufficient decrease in BP at night, an increase in the average daily DBP, PBP, as well as DPAI24, DPTI24, DP and the variability of the average daily SBP. Poor glucose control led to led to an increase in hemodynamic load. It is the risk factor cardiovascular complications in patients with T1DM.

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Importance of food plants in the prevention and treatment of diabetes in Cameroon

Bioactive Compounds in Health and Disease ◽

10.31989/bchd.v2i2.554 ◽

2019 ◽

Vol 2 (2) ◽

pp. 11

Author(s):

Nole Tsabang ◽

Lionel W. ◽

Clément G. Yedjou ◽

Paul B. Tchounwou

Keyword(s):

Herbal Medicines ◽

Food Plants ◽

Diabetic Patients ◽

Self Medication ◽

Prevention And Treatment ◽

Onset Of Diabetes ◽

Group 2 ◽

Group 1

Background: Diabetes is a metabolic pathology that affects the human body’s capacity to produce and use insulin. Type 1 (insulin-dependent) diabetes accounts for 5-10 % of diabetic patients. In Type 2 diabetes the insulin produced by the pancreatic islets is not properly used by cells leading to insulin resistance. Gestational diabetes sometimes occurs in pregnant women and affects about 18 % of all pregnancies. Diabetes is one of the most important multifactorial, metabolic and chronic diseases, with fatal complications. According to the International Diabetes Federation’s estimations in 2015, 415 million people had diabetes. By 2040 this will increase to 642 million. Although many ethnopharmacological surveys have been carried out in several parts of the world, no ethnomedical and ethnopharmacological surveys have been done to identify plants used for the prevention and treatment of diabetes.Objective: This study aimed to collect and document information on food plants’ remedies consumed for preventing and treating diabetes in Cameroon.Methods: Ethnomedical and ethnopharmacological thorough preparation was conducted nearby 1131 interviewers from 58 tribes, in a random distribution. Diabetic patients recorded among the 1,131 people who signed the informed consent and allowed us to evaluate the effectiveness of 10 food plants that they usually used in self-medication. They were divided into two groups: Group 1 was comprised of 42 diabetic patients who regularly consume certain food plants, and Group 2 included 58 patients who were town dwellers and did not regularly eat the identified food plants. Results: It was discovered that the times of onset of diabetes in patients were about 70 years and 45 years in Group 1 and Group 2, respectively. Hence, it was demonstrated that the onset of diabetes was linked to consumption of food plants which contributed to the prevention and/or the delay in its clinical manifestations.Conclusion: The results of this study provide a scientific basis for the use of herbal medicines in the management of diabetes. However further investigations and/or clinical trials involving a large number of both type 1 and type 2 diabetics are needed to confirm the therapeutic action of many food plants against diabetes.Keywords: Cameroon, food plants, diabetes, prevention and treatment

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Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy

Diabetes Mellitus ◽

10.14341/dm2014493-98 ◽

2014 ◽

Vol 17 (4) ◽

pp. 93-98

Author(s):

Sergey Evgen'evich Kostyakov ◽

Irina Leonidovna Alimova

Keyword(s):

Type 1 Diabetes ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Autonomic Neuropathy ◽

Acid Reflux ◽

Diabetic Autonomic Neuropathy ◽

Night Time ◽

Group 2 ◽

Group 1

Aim. We evaluated the clinical and functional characteristics of gastroesophageal reflux disease (GERD) in adolescents with a cardiac form of diabetic autonomic neuropathy. Patients and methods. Fifty-two adolescents, aged 12?17 years, with type 1 diabetes were studied. Patients were divided into two groups according to the results of two autonomic tests (cardiointervalography and Valsalva test). Group 1 included 14 adolescents with a cardiac form of diabetic autonomic neuropathy. Group 2 included 38 controls. Oesophageal pH parameters were monitored over 24 h using a Gastroscan-24. The 24-h period was divided into day-time (08:00?22:00) and night-time (22:00?08:00) periods to eliminate the influence of exogenous factors (such as eating, physical activity and change of body position) on the oesophageal kinetic function. Results. Pathological gastroesophageal reflux occurred more frequently in Group 1 (78.5%) than in Group 2 (36.8%; p=0.018). Heartburn was experienced by 14.3% of the patients in Group 1 and generally occurred with similar frequency in the two groups (p=0.91). The daily amount of pathological acid reflux in Group 1 (86 [62?141]) was higher versus Group 2 (52.5 [24?108]; p=0.047) that was associated with night-time reflux in Group 1. A correlation analysis demonstrated the increase of frequency and intensity of the acid reflux due to development of parasympathetic insufficiency. Conclusion. Diabetic autonomic neuropathy in adolescents with type 1 diabetes appears to be a significant risk factor for the development of pathological subclinical GERD with altered daily pattern.

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Self-reported psychological disorders among the mothers of children with autism spectrum disorder, type 1 diabetes mellitus, and typically developed children

Journal of Neurodevelopmental Disorders ◽

10.1186/s11689-021-09369-y ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Ahmed Malalla Al Ansari ◽

Mohamed Ismael Janahi ◽

Abdulrahman J. AlTourah ◽

Haitham Ali Jahrami ◽

Mansour Bin Rajab

Keyword(s):

Type 1 Diabetes ◽

Diabetes Management ◽

Geographical Area ◽

Children With Autism ◽

Autism Spectrum ◽

Control Group ◽

Management Plans ◽

Group 2 ◽

Group 1

Abstract Background To assess the prevalence of symptoms of depression, anxiety, and stress among mothers of children with autism spectrum disorders (ASD), type 1 diabetes (DM), and typical development (TD), in a geographical area where such data are lacking Method A descriptive study with the three groups of parents of children with and without a condition was conducted (ASD n=126, group 1; DM n=43, group 2; and TD n= 116, comparative group). Measures of depression, anxiety, and stress were collected to examine the prevalence of factors, difference between groups, and their association with demographic characteristics. Results On the DASS-21, both groups 1 and 2 had higher mean scores for depression (37.86), anxiety (4.58), and stress (29.81) than the control group (P=0.015). On the PSS-14, the mean score was higher in group 2 (28.63) than in group 1 (27.61) and the comparison group (25.87) (P=0.004). On the DASS 21, group 1 scored higher in the depression domain (P=0.046), whereas group 2 scored higher in the anxiety domain (P=0.034) and stress domain (P=0.009) than the TD group. Conclusion Mothers of children with ASD should be assessed for the presence of depression following diagnosis. Mothers of children with type 1 diabetes require careful monitoring for the effects of anxiety and stress on their mental health and therefore their ability to cope with diabetes management plans. Trial registration Not applicable.

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The level of antibodies to pneumococcal vaccine in children and adolescents with type 1 diabetes

Problems of Endocrinology ◽

10.14341/probl200955317-20 ◽

2009 ◽

Vol 55 (3) ◽

pp. 17-20 ◽

Cited By ~ 1

Author(s):

M P Kostinov ◽

T V Skochilova ◽

A A Tarasova ◽

V A Vorob'eva ◽

T I Korovkina ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Pneumococcal Vaccine ◽

Baseline Level ◽

Subunit Vaccine ◽

Protective Level ◽

Baseline Levels ◽

Group 2 ◽

Group 1

The trend in the formation of postvaccinal antibodies (Ab) to a mixture of S. pneumoniae polysaccharides (PS) was studied in 100 Pneumo 23-vaccinated children and adolescents with type 1 diabetic (T1D) (Group 1, n = 72) and its combination with the subunit vaccine Grippol (Group 2, n = 28). Following 1-1.5 months, the protective level of Ab l 40 conventional units (CU/ml) was revealed in 95.1 and 85.2% of Groups 1 and 2, respectively; and after 1 year, this was in 55.1 and 37%, respectively (p > 0.05). The level of formation of IgG Ab to a PS mixture did not depend on the age of patients, the duration of T1D, the presence of late diabetic complications. A relationship was found between the formation of postvaccinal Ab and their baseline level: in patients with very low (< 10 CU/ml) and low (10-20 CU/ml) levels of Ab after administration of pneumococcal vaccine, the level of IgG Ab to a S. pneumoniae PS mixture increased by 8.8-4.1 times in the early periods and exceeded the baseline levels by 4.8-2.8 times, respectively. The putative protective level of IgG AB to a S. pneumoniae PS mixture is proposed to be l 20 CU/ml.

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Self-reported psychological disorders among the mothers of children with an autism spectrum disorder, type 1 diabetes mellitus, and typically developed children

10.21203/rs.3.rs-66198/v1 ◽

2020 ◽

Author(s):

Ahmed Malalla Al-Ansari ◽

Mohammed Ismail Janahi ◽

Abdulrahman Jamal AlTourah ◽

Haitham Ali Jahrami ◽

Mansour Bin Rajab

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Management Plan ◽

Autism Spectrum ◽

Control Group ◽

Diabetes Mellitus Group ◽

Children With Asd ◽

Group 2 ◽

Group 1

Abstract ObjectivesTo assess the prevalence of symptoms of depression, anxiety, and stress among mothers of children of autism spectrum disorders (ASD), type 1 diabetes, and typically developed (TD).Method. The study sample comprised mothers of children with ASD ( Group 1; n = 116), diabetes mellitus (Group 2; n = 43 ), and a control group of mothers with TD children.ResultsBoth groups 1 and 2 had higher scores of depression (37.86), anxiety (4.58), and stress (29.81) in DASS-21 in comparison to control (P = 0.015). On PSS-14 The mean score on PSS-14 were: group 1 (27.61), group 2 (28.63) and control (25.87) (p = 0.004). Group 1 scored higher scores for depression domain (p = 0.046) whereas group 2 for anxiety domain (p = 0.034) and stress domain (p = 0.009) in comparison to TD group on DASS-21.ConclusionMothers of children with ASD should be assessed for the presence of depression following diagnosis. Mothers of children with type 1 diabetes required careful monitoring for the effects of anxiety and stress on their mental health, therefore their ability to cope with a management plan.

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Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis

Diabetes Mellitus ◽

10.14341/2072-0351-6013 ◽

2010 ◽

Vol 13 (1) ◽

pp. 27-32

Author(s):

Alexander Evgen'evich Lepetukhin ◽

Nikolay Petrovich Goncharov ◽

Anatoliy Ivanovich Mordik ◽

Natalya Yur'evna Biskaeva

Keyword(s):

Type 1 Diabetes ◽

Combined Treatment ◽

Significant Rise ◽

Total Testosterone ◽

Androgen Deficiency ◽

Ether Mixture ◽

Group 2 ◽

And Control ◽

Group 1

Aim. To study the prevalence of androgen deficiency in men with type 1 diabetes mellitus (DM1) undergoing programmed hemodialysis (PHD) andto develop methods for the treatment of metabolic disorders. Materials and methods. The study included 43 men with DM1 on PHD. Group 1 comprised 20 patients below 40 years of age, group 2 included23 older patients. Patients of group 1 were allocated to subgroup A (treated with testosterone and ether mixture (TEM)); and control subgroup B(n=14 and 6 respectively). Patients of group 2 were divided into subgroup C (treated with TEM) and control subgroup D (n=14 and 9 respectively).Patients in the study and control subgroups were matched for age, duration of DM1, hemodialysis (years), total testosterone (TT, nmol/l), hemoglobin(Hb, g/l) and glycated hemoglobin (HbA1c, %) levels. All the patients were treated with epoetin-beta (EPO-b) on an individual basis depending onHb level; TEM was given thrice weekly. Results. Group 1: age 34.0?3.9 yr, HbA1c 9.3?1.4%, Hb 118.1?9.6 g/l, TT 21.2?6.6 nmol/l. Group 1: age 47.3?3.5 yr, HbA1c 9.5?1.8%,Hb 94.9?5.7 g/l, TT 9.8?3.9 nmol/l. Androgen deficiency was diagnosed in 48.8% (total group), 5.0% (group 1) and 86.9% (group 2) of the patients.Reduction of TT level was not accompanied by a significant rise in LH concentration to above normal values (p>0.05). HbA1c level in eithergroup did not significantly change within 6 months after the onset of the study. Combined treatment with EPO-b and TEM resulted in a Hb concentrationof 118.2?6.7 g/l in subgroup A (p=0.79). Hb level in subgroup C increased to 113.5?6.3 g/l (p=0.009). Hb changes in control groups wereinsignificant. Requirement for EPO-b in subgroups A and C decreased by 32.1% (p=0.007) and 41.1% (p=0.001) respectively but remained unalteredin both control subgroups. Conclusion. Reduction of the TT level in men with DM1 on PHD is a function of age and constitutes an independent risk factor of anemia. Androgendeficiency and its correction have no effect on carbohydrate metabolism. Combined treatment with EPO-b and TEM increases blood Hb level in oldermen and reduces requirement for EPO-b regardless of the age.

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P1043CORRELATION OF ANEMIA AND THYROID HORMONES DISTURBANCES IN PATIENTS WITH TYPE 1 DIABETES AND CHRONIC KIDNEY DISEASE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1043 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

ALENA SAZONAVA ◽

Tatiana Mokhort ◽

Natalia Karlovich

Keyword(s):

Chronic Kidney Disease ◽

Type 1 Diabetes ◽

Kidney Disease ◽

Thyroid Hormones ◽

Serum Iron ◽

Group 3 ◽

Group 2 ◽

Tsh Levels ◽

Group 1

Abstract Background and Aims Impaired thyroid function is a common endocrine pathology among patients with chronic kidney disease (CKD), affecting metabolic parameters, including iron metabolism. The purpose of the study was to investigate potential relationship between thyroid status and iron metabolism profile in patients with type 1 diabetes (T1D) and DKD. Method We recruited 155 patients with T1D. GFR was estimated by CKD-MDRD formula. All patients were divided into 3 groups: the group 1 comprised 59 patients with GFR>60 ml/min; group 2-77 patients with GFR<60 ml/min, group 3- 19 patients, receiving renal replacement therapy (RRT). Biochemical parameters, HbA1c, thyroid hormones, iron homeostasis parameters were measured. Nonparametric statistical methods were used. A P-value <0,05 was considered significant. Results Groups were matched by age of T1D manifestation, HbA1c, BMI, CKD duration in groups 2 and 3. Duration of T1D differed by groups. Comparative analysis of patients in the subgroups revealed reliable differences in TSH levels only between patients from group 1 (p= 0.009), however, in the whole sample and in RRT patients its levels remained within the reference interval. Groups differed by FT4 values (group 1 - 14.12 (12.70-16.25) pmol / L, group 2 - 14.52 (13.27-16, 21), 3 group - 12.25 (11.38-13.48), p1,2 = 0.143, p1,3 = 0.035, p2,3 = 0.003) and FT3 (1 group - 4.43 (4,02-4.89) pmol / L, 2 group - 4.27 (3.98-4.78), 3 group - 1.43 (1.31-1.57), p1,2 = 0.712, p1,3 = 0.002, p2,3 = 0.012) with a tendency to maximum decrease when receiving RRT. No significant differences were obtained according to the levels of total T4 and T3, TG, Ab-TG, AbTPO. Significant decrease in Ab-R-TSH levels (group 1 - 0.70 (0.44-1.67) IU / l, group 2 - 0.40 (0.30-0.88), group 3 - 0.30 (0.30-0, 52), p1,2 = 0.492, p1,3 = 0.009, p2,3 = 0.035) confirms the absence of the influence of autoimmune component on the genesis of thyroid disorders in patients with CKD. No differences were obtained between groups in terms of serum iron levels and total iron binding capacity. Patients significantly differed in ERYTHROCYTES levels (group 1 - 4.68 (4.41-5.01) 109 / l, group 2 - 4.59 (3.96-4.83), group 3 - 3.84 (3, 32-4.27), p1,3 <0.001, p2,3 <0.001), HEMOGLOBIN (group 1 -139.00 (129.00-154.00), group 2 - 135, 00 (115.50-145.00), group 3 - 115.00 (103.00-124.00), p1,2 = 0.025, p1,3 <0.001, p2,3 <0.001), HCT (1 group - 41.90 (39.20-45.10)%, group 2 - 40.75 (35.65-43.70), group 3 - 36.25 (32.90-41.20), p1,3 <0.001, p2,3 = 0.055), TRANSFERRIN (group 1 - 32.90 (30.80-35.60) μmol / L, group 2 - 31.60 (19.20-35, 45) 3 group - 2.45 (2.14-3.65), p1,2 = 0.049, p1,3 <0.001, p2,3 <0.001) and FERRITIN (1 group - 54.00 (33.00- 74.97) μg / L, group 2 - 74.85 (37.18-109.90), group 3 - 152.60 (92.80-329.60), p1,3 < 0,001, p2,3 = 0.001), which reflects the highest sensitivity of these indicators to decrease in renal function. HCT correlated with levels of total T3 (ρ = 0.489), AbTPO (ρ = -0.490), total T4 (ρ = 0.536). Hb levels correlated with total T4 levels (ρ = 0.811), fT3 (ρ = 0.483). Ferritin levels correlated with fT4 (ρ = 0.510), and transferrin with fT3 (ρ = 0.523). Serum iron levels correlated with AbTPO (ρ = -0.656). Conclusion According to revealed changes, possibly anemia contributes to the development of thyroid dysfunctions in patients with diabetic genesis of CKD, due to the involvement of iron in the processes of deiodination and peripheral conversion of thyroid hormones.

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