scholarly journals Tropical spastic paraparesis in Northeastern Brazil

1989 ◽  
Vol 47 (2) ◽  
pp. 134-138 ◽  
Author(s):  
C. M. de Castro Costa ◽  
M. R. Salgueiro ◽  
H. Carton ◽  
O. C. do Vale ◽  
A. M. de Arruda
Keyword(s):  
Bladder Dysfunction ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Northeastern Brazil ◽  
Demyelinating Lesions ◽  
Subsequent Step ◽  
Laboratory Examinations ◽  
Lower Social Class ◽  
Symptoms And Signs

Ten possible cases of tropical spastic paraparesis (TSP) in Northeastern Brazil (Ceará) are presented. They show the typical symptoms and signs of TSP consisting of weakness of the lower limbs, spastic gait, hiperreflexia, bladder dysfunction and variable signs of posterior columns impairment. The laboratory examinations excluded other compressive, infective, degenerative or demyelinating lesions of their spinal cord. Our patients age ranged from 21 to 59 years, all were of black origin and all were of lower social class. There was a slight preponderance of females. An etiological implication of a retrovirus (HTLV-I) has been shown for TSP, but for lack of technical conditions we could not determine it in our patients, and that stands as our subsequent step in those and further cases.

Multiple Sclerosis and HTLV-I associated myelopathy/tropical spastic paraparesis are two distinct clinical entities

1996 ◽  
Vol 2 (2) ◽  
pp. 88-90 ◽  
Author(s):  
Fidias E Leon-S ◽  
Kimiyoshi Arimura ◽  
Mitsuhiro Osame
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Features ◽  
Spastic Paraparesis ◽  
Early Response ◽  
Blink Reflex ◽  
Tropical Spastic Paraparesis ◽  
Diagnosis And Therapy ◽  
Neurophysiological Data ◽  
Demyelinating Lesions ◽  
Radiological Studies

Multiple sclerosis (MS) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) can overlap in their clinical features and thereby cause difficulties for clinicians in relation to diagnosis and therapy. However, epidemiological biochemical, immunological, virological and radiological studies point to a number of significant differences. Recent comparative neurophysiological data, induding blink reflex studies, obtained in these disorders, is briefly reviewed here and provides additional evidence of difference. The abnormal blink reflex in patients with MS consist of prolonged latencies and absences of R1 and R2 responses and are mainly due to demyelinating lesions around the pons. In contrast, in HAM/TSP the blink reflex abnormalities frequently include an unusual early response, R/k, which is probably a consequence of interneuronal hyperexcitability around the brainstem. Thus these findings provide further support for our contention that HAM/TSP and multiple sclerosis are distinctly different both as clinical entities and in their underlying pathomechanisms.

HTLV-Negative and HTLV Type I-Positive Tropical Spastic Paraparesis in Northeastern Brazil

1995 ◽  
Vol 11 (2) ◽  
pp. 315-318 ◽  
Author(s):  
C.M. DE CASTRO COSTA ◽  
P. GOUBAU ◽  
H.-F. LIU ◽  
A.-M. VANDAMME ◽  
F.M.B. DA CUNHA ◽  
...  
Keyword(s):  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Northeastern Brazil ◽  
Type I

scholarly journals PERFORMANCE OF THE GAIT IN INDIVIDUALS WITH HTLV-1: SYSTEMATIC REVIEW

2017 ◽  
Vol 7 (3) ◽  
pp. 319-325
Author(s):  
Mateus Evangelista do Amparo Santana ◽  
Livia Aguiar Pereira ◽  
Rafael Monteiro ◽  
Erika Pedreira Fonseca
Keyword(s):  
Systematic Review ◽  
Spastic Paraparesis ◽  
Gait Pattern ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Functional Changes ◽  
Gait Parameters ◽  
Access Information ◽  
Muscle Groups ◽  
The Individual

HTLV-1 is frequently associated with myelopathy/tropical spastic paraparesis (HAM/TSP), which in turn brings several functional alterations to the individual, including changes in gait. Objective: To systematize the scientific findings on the temporo-spatial gait parameters in individuals with HTLV-1. Methodology:  This is a systematic review of the scientific literature. The primary search of the articles was performed in the Pubmed, Scielo and Bireme databases, and observational studies were included that evaluated gait changes in individuals with HTLV-1. The search strategy was conducted by two researchers apart and the divergences resolved by consensus.  Results:  Firstly, it has found 40 studies and considering them, it was included two studies that investigated the changes in gait performance among the individuals with HTLV-1, within a total of 97 individuals. Conclusion:  This systematic review identified changes in gait pattern among individuals with tropical spastic paraparesis/myelopathy associated to HTLV-1; functional changes in muscle groups of the lower limbs and slowing gait speed are among the main findings, but the lack of published work on the subject makes it difficult to access information. Therefore, it is suggested that new approaches be made for a better understanding of this topic.

scholarly journals INTERFERON BETA-1A TREATMENT IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS: A CASE REPORT

2014 ◽  
Vol 56 (5) ◽  
pp. 443-445 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Marcos Antonio Custódio Neto da Silva ◽  
Victor Lima Souza ◽  
Natália Barbosa da Silva Lopes ◽  
Diego Luz Felipe da Silva ◽  
...  
Keyword(s):  
Interferon Beta ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Slight Reduction ◽  
Urinary Urgency ◽  
Varicella Zoster ◽  
Barr Virus ◽  
Left Limb ◽  
Epstein Barr

Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and laboratory tests confirmed the presence of antibodies to HTLV-1 in the cerebrospinal fluid (CSF). Mumps, cytomegalovirus, Epstein-Barr virus, schistosomiasis, herpes virus 1 and 2, rubella, measles, varicella-zoster toxoplasmosis, hepatitis, HIV, and syphilis were excluded by serology. The patient was diagnosed with neurogenic bladder and presented with nocturia, urinary urgency, paresthesia of the lower left limb, a marked reduction of muscle strength in the lower limbs, and a slight reduction in upper limb strength. During the fourth week of treatment with interferon beta-1a, urinary urgency and paresthesia disappeared and clinical motor skills improved.

The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

1999 ◽  
Vol 73 (6) ◽  
pp. 4575-4581 ◽  
Author(s):  
Masahiko Makino ◽  
Satoshi Shimokubo ◽  
Shin-Ichi Wakamatsu ◽  
Shuji Izumo ◽  
Masanori Baba
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Normal Donor ◽  
Dependent Manner ◽  
T Lymphotropic Virus

ABSTRACT The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor monocytes by using recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin-4, were pulsed with HTLV-1 in vitro. The pulsed DCs contained HTLV-1 proviral DNA and expressed HTLV-1 Gag Ag on their surface 6 days after infection. The DCs matured by lipopolysaccharides stimulated autologous CD4+ T cells and CD8+ T cells in a viral dose-dependent manner. However, the proliferation level of CD4+ T cells was five- to sixfold higher than that of CD8+ T cells. In contrast to virus-infected DCs, DCs pulsed with heat-inactivated virions activated only CD4+ T cells. To clarify the role of DCs in HAM/TSP development, monocytes from patients were cultured for 4 days in the presence of the cytokines. The expression of CD86 Ag on DCs was higher and that of CD1a Ag was more down-regulated than in DCs generated from normal monocytes. DCs from two of five patients expressed HTLV-1 Gag Ag. Furthermore, both CD4+ and CD8+ T cells from the patients were greatly stimulated by contact with autologous DCs pulsed with inactivated viral Ag as well as HTLV-1-infected DCs. These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP.

scholarly journals Pregnancy complicated by HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP): a case report

2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Hiroshi Mori ◽  
Eiji Shibata ◽  
Tomoichiro Kuwazuru ◽  
Takayuki Uchimura ◽  
Emi Kondo ◽  
...  
Keyword(s):  
Case Report ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis
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