scholarly journals PERFORMANCE OF THE GAIT IN INDIVIDUALS WITH HTLV-1: SYSTEMATIC REVIEW

2017 ◽  
Vol 7 (3) ◽  
pp. 319-325
Author(s):  
Mateus Evangelista do Amparo Santana ◽  
Livia Aguiar Pereira ◽  
Rafael Monteiro ◽  
Erika Pedreira Fonseca
Keyword(s):  
Systematic Review ◽  
Spastic Paraparesis ◽  
Gait Pattern ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Functional Changes ◽  
Gait Parameters ◽  
Access Information ◽  
Muscle Groups ◽  
The Individual

HTLV-1 is frequently associated with myelopathy/tropical spastic paraparesis (HAM/TSP), which in turn brings several functional alterations to the individual, including changes in gait. Objective: To systematize the scientific findings on the temporo-spatial gait parameters in individuals with HTLV-1. Methodology:  This is a systematic review of the scientific literature. The primary search of the articles was performed in the Pubmed, Scielo and Bireme databases, and observational studies were included that evaluated gait changes in individuals with HTLV-1. The search strategy was conducted by two researchers apart and the divergences resolved by consensus.  Results:  Firstly, it has found 40 studies and considering them, it was included two studies that investigated the changes in gait performance among the individuals with HTLV-1, within a total of 97 individuals. Conclusion:  This systematic review identified changes in gait pattern among individuals with tropical spastic paraparesis/myelopathy associated to HTLV-1; functional changes in muscle groups of the lower limbs and slowing gait speed are among the main findings, but the lack of published work on the subject makes it difficult to access information. Therefore, it is suggested that new approaches be made for a better understanding of this topic.

scholarly journals Tropical spastic paraparesis in Northeastern Brazil

1989 ◽  
Vol 47 (2) ◽  
pp. 134-138 ◽  
Author(s):  
C. M. de Castro Costa ◽  
M. R. Salgueiro ◽  
H. Carton ◽  
O. C. do Vale ◽  
A. M. de Arruda
Keyword(s):  
Bladder Dysfunction ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Northeastern Brazil ◽  
Demyelinating Lesions ◽  
Subsequent Step ◽  
Laboratory Examinations ◽  
Lower Social Class ◽  
Symptoms And Signs

Ten possible cases of tropical spastic paraparesis (TSP) in Northeastern Brazil (Ceará) are presented. They show the typical symptoms and signs of TSP consisting of weakness of the lower limbs, spastic gait, hiperreflexia, bladder dysfunction and variable signs of posterior columns impairment. The laboratory examinations excluded other compressive, infective, degenerative or demyelinating lesions of their spinal cord. Our patients age ranged from 21 to 59 years, all were of black origin and all were of lower social class. There was a slight preponderance of females. An etiological implication of a retrovirus (HTLV-I) has been shown for TSP, but for lack of technical conditions we could not determine it in our patients, and that stands as our subsequent step in those and further cases.

scholarly journals Botulinum toxin type A in the treatment of lower-limb spasticity in children with cerebral palsy

2009 ◽  
Vol 67 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Carlos Henrique F. Camargo ◽  
Hélio A.G. Teive ◽  
Marise Zonta ◽  
Gilmar C. Silva ◽  
Marcelo R. Oliveira ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Botulinum Toxin ◽  
Structural Changes ◽  
Botulinum Toxin A ◽  
Botulinum Toxin Type A ◽  
Botulinum Toxin Type ◽  
Gait Pattern ◽  
Peak Effect ◽  
Lower Limbs ◽  
Functional Changes

We evaluated the safety and effectiveness of botulinum toxin A (BoNT/A) in the treatment of spasticity in 20 children with spastic diplegic cerebral palsy (CP). All the patients received injections in the gastrocnemius and soleus, and 15 received injections in the adductors. The total dose varied from 70 to 140 U (99.75±16.26 U), or 7.45±2.06 U/kg per patient. The treatment improved the patients' walking and gait pattern significantly. There was also a significant alteration in the heel-ground distance and increased motion of the ankle joint. These structural changes in the feet were sustained until the end of the follow-up, although the same was not observed for the functional parameters. Three patients complained of weakness in the lower limbs. In conclusion, BoNT/A is safe and effective when used in a single session of injections and produces a sustained structural modification of the lower limbs. However, functional changes are temporary and are only observed during the peak effect of the drug.

Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review

2021 ◽  
Vol 14 (8) ◽  
pp. 333
Author(s):  
LucianeAmorim Santos ◽  
AnaCarolina Marinho Monteiro Lima ◽  
GreiceCarolina Santos da Silva ◽  
FernandaKhouri Barreto ◽  
FilipeFerreira de Almeida Rego ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis

scholarly journals Comparison of Molded and Conventional Orthosis during Ambulation for Adolescent with Myelomeningocele

2017 ◽  
Vol 28 (2) ◽  
pp. 77-83
Author(s):  
Rajesh K Mohanty ◽  
Sipra Lenka ◽  
Ritikesh Pattanaik ◽  
Srikanta Moharana ◽  
Patitapaban Mohanty ◽  
...  
Keyword(s):  
Force Plate ◽  
Hip Dislocation ◽  
Lower Limbs ◽  
Kinematic Parameters ◽  
Individual Subject ◽  
Gait Parameters ◽  
Anterior Pelvic Tilt ◽  
Walking Velocity ◽  
The Individual

ABSTRACT Varying diversities of involvement in adolescent with myelomeningocele make orthotic prescription, evaluation, and fitting highly challenging. A school-going 14-year-old boy presented with extensive weakness and kinematic alterations of both lower limbs and spine. Planovalgoid foot, calcaneal deformity of ankle, knee flexion, anterior pelvic tilt, rotation, and frequent hip dislocation of left side were noticed on examination. Gait comparisons were made between walking with bare foot and with conventional and molded orthosis with auxiliary crutches. Kinetic and kinematic parameters were studied in gait lab by force plate (BTS P-6000) and cameras with reflective markers (BTS SMART-DX 6000). Molded orthosis was found to improve all gait parameters except cadence and walking velocity; however, diversity in the results was observed. Though both variants were effective, a follow-up is necessary to finalize the best orthotic solution for the individual subject. How to cite this article Mohanty RK, Lenka S, Pattanaik R, Moharana S, Mohanty P, Das SP. Comparison of Molded and Conventional Orthosis during Ambulation for Adolescent with Myelomeningocele. Indian J Phy Med Rehab 2017;28(2):77-83.

scholarly journals INTERFERON BETA-1A TREATMENT IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS: A CASE REPORT

2014 ◽  
Vol 56 (5) ◽  
pp. 443-445 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Marcos Antonio Custódio Neto da Silva ◽  
Victor Lima Souza ◽  
Natália Barbosa da Silva Lopes ◽  
Diego Luz Felipe da Silva ◽  
...  
Keyword(s):  
Interferon Beta ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Lower Limbs ◽  
Slight Reduction ◽  
Urinary Urgency ◽  
Varicella Zoster ◽  
Barr Virus ◽  
Left Limb ◽  
Epstein Barr

Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and laboratory tests confirmed the presence of antibodies to HTLV-1 in the cerebrospinal fluid (CSF). Mumps, cytomegalovirus, Epstein-Barr virus, schistosomiasis, herpes virus 1 and 2, rubella, measles, varicella-zoster toxoplasmosis, hepatitis, HIV, and syphilis were excluded by serology. The patient was diagnosed with neurogenic bladder and presented with nocturia, urinary urgency, paresthesia of the lower left limb, a marked reduction of muscle strength in the lower limbs, and a slight reduction in upper limb strength. During the fourth week of treatment with interferon beta-1a, urinary urgency and paresthesia disappeared and clinical motor skills improved.

Intrinsic and Extrinsic Cell Apoptotic Pathways in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Systematic Review

2021 ◽  
Author(s):  
Ana Patrícia Bastos Ferreira ◽  
Ana Paula Pimentel Cassilhas ◽  
Patrícia Moura ◽  
Pedro Augusto Sampaio Rocha-Filho
Keyword(s):  
Systematic Review ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Apoptotic Pathways

scholarly journals POSTURAL PROFILE OF PATIENTS WITH HAM/TSP: COMPUTERIZED AND BAROPODOMETRIC ASSESSMENT

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Edelvita Fernanda Duarte Cunha ◽  
Naiane Araújo Patrício ◽  
Maíra Carvalho Macedo ◽  
Cristiano Sena ◽  
Ramon Kruschewsky ◽  
...  
Keyword(s):  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Cross Sectional ◽  
Adult T Cell Leukemia ◽  
Postural Changes ◽  
Ankle Angle ◽  
Predominantly Female ◽  
The Individual ◽  
The Right ◽  
Hip Extension

Background: The HTLV-1 was the first retrovirus-associated with disease in human, being mainly associated with adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-1–associated myelopathy (TSP/HAM). In the predominant clinical condition of HAM/TSP, biomechanical, sensory and functional alterations are observed. Objective: To describe and correlate postural deviations and the type of predominant weight load. Methods: This is a cross-sectional descriptive study, conducted with patients at the Center for HTLV, Salvador – Bahia. Data collection was performed in two steps, first evaluating postural orthostatic through digital photos of the individual, following the protocol SAPO® to mark anatomical points, the second step was the Baropodometric evaluation. For correlation of weight load and postural changes we used Pearson or Spearman correlation tests (a<0.05). Results: We studied 31 individuals, predominantly female (54.8%), african descent (58.1%), with a mean age of 52.8 (+ 9.89) years. Analysis showed a predominance by an anteriorized position of the head (80.6%), trunk displaced posteriorly (64.5%), anteriorized body (96,8%), hip extension (77.4%), pelvic retroversion (61.3%), flexed knee (51.6%) with genu valgus (right 64.5%, left 74.2%) right hindfoot valgus (64.5%) and left varus (71.0%), and a reduction in the ankle angle (100%), discharge weight of the right foot and bilateral forefoot. It was observed a significant correlation between changes in anteriorized body, flexed knee and reduction in the ankle angle to the weight load of bilateral forefoot, and pelvic retroversion with the weight load of his right foot. Conclusion: Patients with tropical spastic paraparesis have significant postural changes that alter their weight discharge.

The importance and significance of gene polymorphisms in preeclampsia

2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Early Diagnosis ◽  
Gene Polymorphisms ◽  
Individual Risk ◽  
Extended Study ◽  
Stress Genes ◽  
Detoxification System ◽  
The Individual ◽  
The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

Anti-Inflammatory Properties of Plant Derived Natural Products – A Systematic Review

2019 ◽  
Vol 26 (24) ◽  
pp. 4506-4536 ◽  
Author(s):  
Iris E. Allijn ◽  
René P. Brinkhuis ◽  
Gert Storm ◽  
Raymond M. Schiffelers
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Positive Control ◽  
Therapeutic Effects ◽  
Reference Compound ◽  
Individual Molecular Species ◽  
The Past ◽  
Anti Inflammatory ◽  
The Individual ◽  
Natural Medicines

Traditionally, natural medicines have been administered as plant extracts, which are composed of a mixture of molecules. The individual molecular species in this mixture may or may not contribute to the overall medicinal effects and some may even oppose the beneficial activity of others. To better control therapeutic effects, studies that characterized specific molecules and describe their individual activity that have been performed over the past decades. These studies appear to underline that natural products are particularly effective as antioxidants and anti-inflammatory agents. In this systematic review we aimed to identify potent anti-inflammatory natural products and relate their efficacy to their chemical structure and physicochemical properties. To identify these compounds, we performed a comprehensive literature search to find those studies, in which a dose-response description and a positive control reference compound was used to benchmark the observed activity. Of the analyzed papers, 7% of initially selected studies met these requirements and were subjected to further analysis. This analysis revealed that most selected natural products indeed appeared to possess anti-inflammatory activities, in particular anti-oxidative properties. In addition, 14% of the natural products outperformed the remaining natural products in all tested assays and are attractive candidates as new anti-inflammatory agents.

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