Early-onset Parkinson's disease and depression

Patients with Parkinson’s disease (PD) in whom symptoms start before the age of 45 years (EOPD) present different clinical characteristics from those with the late-onset form of the disease. The incidence of depression is believed to be greater in patients with EOPD than with the late-onset form of the disease, although there is no risk factor or marker for depression in patients with PD. We studied 45 patients with EOPD to define the frequency of depression and to identify possible differences between the groups with and without depression. Depression was diagnosed in 16 (35.5%) of the patients, a higher incidence than in the population at large but similar to the figure for late-onset Parkinson disease; 8 (50%) of the patients had mild depression, 4 (25%) moderate depression and 4 (25%) were in remission. There was no relationship between depression and any of the clinical characteristics of the disease, although the EOPD patients with depression presented earlier levodopa-related complications and were more affected on the Hoehn-Yahr, UPDRS and Schwab-England scales.

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Genetic Insights into Early-onset Parkinson’s Disease

US Neurology ◽

10.17925/usn.2010.06.01.41 ◽

2010 ◽

Vol 06 (01) ◽

pp. 41

Author(s):

Roy N Alcalay ◽

Cheryl Waters ◽

◽

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Family History ◽

Early Onset ◽

Late Onset ◽

Positive Family History ◽

Disease Onset ◽

Leucine Rich Repeat ◽

Strong Family History ◽

Early Onset Parkinson’S Disease

Early-onset Parkinson’s disease (EOPD) is defined as disease onset before 40 or 50 years of age. The clinical characteristics of EOPD are very similar to those of late-onset PD, but dystonia is more often a presenting symptom, dementia is rare, and disease progression may be slower. Mutations in several genes have been described in cases with EOPD, often with strong family history, including mutations in α-synuclein (SNCA),DJ-1, PTEN-induced kinase-1 (PINK-1), andATP13A2. However, the most common mutations identified in EOPD are in Parkin (PRKN), leucine-rich repeat kinase 2 (LRRK2), and glucocerebrosidase (GBA). With the exception ofSNCAandATP13A2carriers, mutation carriers are often indistinguishable from non-carriers. Large series of EOPD cases that are not ascertained by family history estimate mutation frequency at 4–16%. Given that the frequency of positive family history is much higher, we believe that many genetic risk factors are yet to be discovered.

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LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

Journal of Neural Transmission ◽

10.1007/s00702-008-0065-0 ◽

2008 ◽

Vol 115 (9) ◽

pp. 1275-1277 ◽

Cited By ~ 16

Author(s):

Daniel Kam Yin Chan ◽

Ping Wing Ng ◽

Vincent Mok ◽

Jonas Yeung ◽

Zhi Ming Fang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Clinical Features ◽

Early Onset ◽

Chinese Population ◽

Late Onset ◽

Early Onset Parkinson’S Disease

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Genetic Insights into Early-onset Parkinson's Disease

European Neurological Review ◽

10.17925/enr.2010.05.01.30 ◽

2010 ◽

Vol 5 (1) ◽

pp. 30

Author(s):

Roy N Alcalay ◽

Cheryl Waters ◽

◽

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Family History ◽

Genetic Risk ◽

Early Onset ◽

Late Onset ◽

Positive Family History ◽

Disease Onset ◽

Strong Family History ◽

Early Onset Parkinson’S Disease

Early-onset Parkinson's disease (EOPD) is defined as disease onset before 40 or 50 years of age. The clinical characteristics of EOPD are very similar to those of late-onset PD, but dystonia is more often a presenting symptom, dementia is rare and disease progression may be slower. Mutations in several genes have been described in cases with EOPD, often with strong family history, including mutations in α-synuclein (SNCA),DJ-1,PTEN-induced kinase-1 (PINK-1) andATP13A2. However, the most common mutations identified in EOPD are in Parkin (PRKN), leucinerich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA). With the exception ofSNCAandATP13A2carriers, mutation carriers are often indistinguishable from non-carriers. Large series of EOPD cases that are not ascertained by family history estimate mutation frequency at 4–16%. Given that the frequency of positive family history is much higher, we believe that many genetic risk factors are yet to be discovered.

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Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000447533 ◽

2016 ◽

Vol 42 (1-2) ◽

pp. 17-30 ◽

Cited By ~ 6

Author(s):

Ana Natalia Seubert-Ravelo ◽

M. Guillermina Yáñez-Téllez ◽

Hermelinda Salgado-Ceballos ◽

Rodrigo Erick Escartín-Pérez ◽

Gabriel Adolfo Neri-Nani ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Executive Function ◽

Mild Cognitive Impairment ◽

Early Onset ◽

Late Onset ◽

Motor Symptoms ◽

Visuospatial Abilities ◽

Early Onset Parkinson’S Disease

Background/Aims: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD. Methods: Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory. Scores were compared with age/education-appropriate norms and were correlated to years of disease progression and severity of motor symptoms. The frequency of MCI and dementia was determined by the Movement Disorder Society criteria. Results: Thirty-one percent of patients met the MCI criteria, but none had dementia. Commonly affected domains were memory, visuospatial, and executive function. Cognitive dysfunction was not explained by depression or severity of motor symptoms. Conclusion: One third of EOPD patients presented with MCI, which was not associated with the same risk factors as reported in late-onset Parkinson's disease. MCI could have a different prognostic value in EOPD.

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