Morbidity due to Schistosoma mansoni - Entamoeba histolytica coinfection in hamsters (Mesocricetus auratus)

Data on Schistosoma mansoni-Entamoeba histolytica coinfection are scarce in the literature. In the present study, hamsters that had been infected for 70 days with Schistosoma mansoni (LE strain) were inoculated via the portal vein with two strains of trophozoites of Entamoeba histolytica: ICB-EGG (highly virulent) and ICB-RPS (non-virulent). The most evident result of coinfection was increased morbidity and mortality, in comparison with either of the infections alone. Histologically, there were no evident signs of interaction between these two infections. The morphological findings of schistosomal granuloma and amoebic abscesses in the liver were similar to those seen in the respective single-infection controls. However, there was severe wasting of the animals with both infections and greater numbers of amoebic lesions in their livers. The results obtained indicated that schistosomiasis aggravates the course of amoebiasis in hamsters.

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Faculty Opinions recommendation of A possible cluster of sexually transmitted Entamoeba histolytica: genetic analysis of a highly virulent strain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1164627.626423 ◽

2009 ◽

Author(s):

Jacqueline Upcroft

Keyword(s):

Genetic Analysis ◽

Entamoeba Histolytica ◽

Virulent Strain ◽

Sexually Transmitted ◽

Highly Virulent

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Comparison of morbidity and mortality rates after two different methods of portal vein reconstruction in patients with borderline resectable pancreatic cancer (BRPC) and TYPE 4 vein resection according to the ISGPS classification scheme

Pancreatology ◽

10.1016/j.pan.2015.05.363 ◽

2015 ◽

Vol 15 (3) ◽

pp. S100

Author(s):

Magdalena Derejska ◽

Marek Durlik

Keyword(s):

Pancreatic Cancer ◽

Portal Vein ◽

Classification Scheme ◽

Mortality Rates ◽

Morbidity And Mortality ◽

Resectable Pancreatic Cancer ◽

Borderline Resectable ◽

Borderline Resectable Pancreatic Cancer ◽

Portal Vein Reconstruction ◽

Vein Resection

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Comparative study on the localization of adult Schistosoma mansoni worms in albino mice anesthetized with pentobarbital sodium, ether or chlorophorm

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651993000400003 ◽

1993 ◽

Vol 35 (4) ◽

pp. 323-326 ◽

Cited By ~ 2

Author(s):

José Roberto Machado e Silva ◽

Maria Adriana Dias de Lima ◽

Rosângela Rodrigues e Silva ◽

Arnaldo Maldonado Jr. ◽

Octávio Augusto França Presgrave ◽

...

Keyword(s):

Portal Vein ◽

Comparative Study ◽

Schistosoma Mansoni ◽

Control Group ◽

Pentobarbital Sodium ◽

Mesenteric Veins ◽

Anesthetic Drugs ◽

Albino Mice ◽

The Difference

The effect of anesthetic drugs on the localization of adult worms in albino mice was compared. The animals with 56 days of infection were anesthetized with pentobarbital sodium, ether or chlorophorm. Perfusion was carried out immediately after, recovering the worms and classifying them in relation to their localization on the liver or portal vein and the mesenteric veins. Our results showed that pentobarbital sodium produced a greater displacement of the worms to the liver (89%) than ether (76%) and chlorophorm (34%) did, when compared to the control group (22%). The difference between pentobarbital sodium and ether was significant (p < 0.05). We suggest that anesthetic drugs may not be used in studies on the distribution of adult worms in several hosts.

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A contribution to the study of acute schistosomiasis (an experimental trial)

Memórias do Instituto Oswaldo Cruz ◽

10.1590/s0074-02761987000300001 ◽

1987 ◽

Vol 82 (3) ◽

pp. 311-317 ◽

Cited By ~ 9

Author(s):

Zilton A. Andrade ◽

Theomira Mauadie de Azevedo

Keyword(s):

Schistosoma Mansoni ◽

Experimental Model ◽

Murine Model ◽

Single Infection ◽

Coagulative Necrosis ◽

Histological Changes ◽

Experimental Trial ◽

Repeated Infections ◽

Major Factors ◽

Inflammatory Changes

In an attempt to establish an experimental model of acute schistosomiasis, sequential histological changes were investigated in the skin, lung, liver and spleen of mice infected with 30 or 100 cercariae of Schistosoma mansoni according to four sets of experiments: single infection, repeated infections, unisexual infection and infection in mice born from infected mothers. Animals were killed every other day from exposure up to 50 days after infection. Only mild, isolated, focal inflammatory changes were found before the appearance of mature eggs in the liver, even when repeated infections were made. Severe changes of reactive hepatitis and splenitis appeared suddenly when the first mature eggs were deposited, around the 37th to 42nd day after infection. The mature eggs induced lytic and coagulative necrosis of hepatocytes around them which was soon followed by dense infiltration of eosinophils. So, mature egg-induced lesions appeared as the major factors in the pathogenesis of acute schistosomiasis in mice. Mice born from infected mothers were apparently able to rapidly modulate the egg-lesions, forming early fibrotic granulomas. The murine model of acute schistosomiasis appeared adequate for the study of pathology and pathogenesis of acute schistosomiasis.

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Increased Morbidity and Mortality of Patients with Non-cirrhotic Portal Vein Thrombosis After Abdominal and Pelvic Surgeries: a Study of the National Inpatient Sample 2002 to 2015

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-020-04818-w ◽

2020 ◽

Author(s):

Wuttiporn Manatsathit ◽

Kishan Patel ◽

Thomas Enke ◽

Harlan Sayles ◽

Loretta L. Jophlin ◽

...

Keyword(s):

Portal Vein ◽

Portal Vein Thrombosis ◽

Morbidity And Mortality ◽

National Inpatient Sample ◽

Vein Thrombosis

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Entamoeba histolytica Neglected Tropical Diseases (NTDs) Agents that Infect Humans and Some Other Mammals: A Review

E3S Web of Conferences ◽

10.1051/e3sconf/202015101019 ◽

2020 ◽

Vol 151 ◽

pp. 01019

Author(s):

Junaidi Junaidi ◽

Umi Cahyaningsih ◽

Trioso Purnawarman ◽

Hadri Latif ◽

Etih Sudarnika ◽

...

Keyword(s):

Public Health ◽

Entamoeba Histolytica ◽

Search Engines ◽

Neglected Tropical Diseases ◽

Morbidity And Mortality ◽

Google Scholar ◽

Intestinal Lumen ◽

High Morbidity ◽

Tropical Diseases

Amoebiasis caused by Entamoeba histolytica is an important issue in world public health because it is associated with high morbidity and mortality. Entamoeba histolytica is the only species of its genus that commonly causes mild irritation, injury, to inflammation of the walls of the colon and cecum. In some cases, parasites also invade other organs, especially the liver, lungs, kidneys, and brain. Methods: Our article search uses the help of four search engines namely Google Scholar, PubMed, Science Direct, and Springer. Results: Entamoeba histolytica is not easily transmitted from animals to humans, due to the fact that this parasite rarely encysts in the intestinal lumen of animals which is an important factor in the transmission of this parasite. And conversely, subclinical amebiasis in humans acts as the dominant host for transmission of this parasite either from human to human or from human to animal.

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A comparative study of Multiple versus Single infection doses of Schistosoma haematobium in Golden hamsters (Mesocricetus auratus)

African Journal of Health Sciences ◽

10.4314/ajhs.v14i3.30864 ◽

2008 ◽

Vol 14 (3) ◽

Author(s):

VK Njoroge ◽

F Nyundo ◽

M Limo ◽

DS Yole

Keyword(s):

Comparative Study ◽

Schistosoma Haematobium ◽

Mesocricetus Auratus ◽

Single Infection ◽

Golden Hamsters

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Commentary on “Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases?”

Surgery ◽

10.1016/j.surg.2014.08.093 ◽

2015 ◽

Vol 157 (2) ◽

pp. 207-210 ◽

Cited By ~ 5

Author(s):

Jean-Nicolas Vauthey ◽

Yoshihiro Mise

Keyword(s):

Portal Vein ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Morbidity And Mortality ◽

Portal Vein Ligation ◽

Staged Hepatectomy

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Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. The effect of varying the route and the number of primary infections, and the correlation between the size of the primary infection and the degree of resistance that is acquired

Parasitology ◽

10.1017/s0031182000056092 ◽

1980 ◽

Vol 81 (2) ◽

pp. 355-371 ◽

Cited By ~ 17

Author(s):

E. Long ◽

R. Harrison ◽

Q. Bickle ◽

J. Bain ◽

G. Nelson ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Primary Infection ◽

Worm Burden ◽

The Other ◽

Single Infection ◽

Factors Affecting ◽

Relative Lack ◽

Skin Site ◽

Homologous Challenge ◽

Inducing Resistance

SUMMARYMice given primary infections of Schistosoma mansoni by percutaneous or subcutaneous routes were found to acquire a higher degree of resistance against homologous challenge after 7–8 weeks than mice infected intraperitoneally. Mice infected by the intraperitoneal route tended to have smaller worm burdens than those infected with the same number of cercariae by the other two routes and this may, in part, have contributed to the relative lack of efficacy of intraperitoneal infections in inducing resistance to re-infection. The same degree of resistance was acquired after primary percutaneous infection irrespective of whether it was administered in 3 equivalent weekly doses, or the same total number of cercariae was administered as a single infection. The same degree of resistance was also observed when a percutaneous challenge was administered on the same or a different skin site to that which received the percutaneous primary infection. The degree of resistance to re-infection acquired after a percutaneous primary infection correlated well with the size of the primary worm burden and the number of eggs in the intestine and liver, but did not correlate with the number of eggs in the lungs.

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