scholarly journals Liver synthesis function in chronic asymptomatic or oligosymptomatic alcoholics: correlation with other liver tests

1999 ◽  
Vol 54 (3) ◽  
pp. 97-102 ◽  
Author(s):  
Paulo Borini ◽  
Romeu Cardoso Guimarães
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Hepatic Dysfunction ◽  
Serum Bilirubin ◽  
Serum Alkaline Phosphatase ◽  
Nutritional Deficiencies ◽  
Hepatic Enzymes ◽  
Prothrombin Activity ◽  
Gamma Glutamyltransferase ◽  
Liver Tests

Liver function and its correlation with bilirubin and hepatic enzymes were evaluated in 30 male chronic asymptomatic or oligosymptomatic alcoholics admitted into the psychiatric hospital for detoxification and treatment of alcoholism. Hypoalbuminemia, lowered prothrombin activity, hypotransferrinemia and hypofibrinogenemia were detected in 32 %, 32 %, 28 %, and 24 % of patients, respectively. Transferrin was elevated in 8 %. Greater prevalence of hyperbilirubinemia was found in patients with lowered prothrombin activity, hypofibrinogenemia, or hypotransferrinemia. No correlation was found between serum bilirubin or aminotransferase levels and normal or elevated albumin levels, time or activity of prothrombin, and fibrinogen levels. Serum alkaline phosphatase was elevated in normoalbuminemics and gamma-glutamyltransferase in patients with lowered prothrombin activity. Hypoalbuminemia was associated with hypofibrinogenemia, hypotransferrinemia with elevated aspartate aminotransferase or gamma-glutamyltransferase, and hypertransferrinemia with elevation of alanine aminotransferase. These data indicated the occurrence of hepatic dysfunction due to liver damage caused directly by alcohol or by alcoholism-associated nutritional deficiencies.

Value of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver.

1977 ◽  
Vol 23 (11) ◽  
pp. 2034-2038 ◽  
Author(s):  
N K Kim ◽  
W G Yasmineh ◽  
E F Freier ◽  
A I Goldman ◽  
A Theologides
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Metastases ◽  
Glutamate Dehydrogenase ◽  
False Positive ◽  
Serum Alkaline Phosphatase ◽  
False Negative ◽  
Diagnostic Value ◽  
Gamma Glutamyltransferase ◽  
Activity Measurements ◽  
Positive Results

Abstract We assessed, in 98 patients with cancer, the diagnostic value of measuring serum alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activities as an aid to detection of liver metastases. All four enzymes showed diagnostic value, but 5'-nucleotidase appeared to have the greatest. It showed the lowest false-positive results (7.4%) with the highest predictive value of a positive test (85.7%) and agreement (81.3%).. gamma-Glutamyltransferase showed the lowest proportion of false-negative results (2.8%), but was the least specific 35% false-positive results). Analysis of various test combinations showed that the best agreement (77.5%) was obtained when the patients were divided into those who had no or only one abnormal test result, and those who had two or more abnormal test results. However, this was not better than the agreement for 5' nucleotidase alone (81.3%). The agreement of 5'-nucleotidase and gamma-glutamyltransferase (i.e., both tests were positive or negative) was excellent (91.4%), but such agreement included only 67% of the patients with liver metastases.

Interference in an automated radial partition fluorescent immunoassay of thyrotropin associated with liver-function abnormalities

1990 ◽  
Vol 36 (7) ◽  
pp. 1343-1345 ◽  
Author(s):  
D B Sacks ◽  
M M Lim ◽  
C A Parvin ◽  
G Kessler
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Biochemical Markers ◽  
Total Bilirubin ◽  
Regression Line ◽  
Positive Bias ◽  
Gamma Glutamyltransferase ◽  
Residual Variability

Abstract In a previous evaluation of a "sensitive" radial partition fluorescent immunoassay on the Stratus system, thyrotropin (TSH) values exhibited a positive bias in icteric samples when compared with results of a nonsensitive radioimmunoassay. In the present study, we evaluated 366 patients samples to assess whether any biochemical markers of liver function could identify samples for which TSH values would be falsely increased. gamma-Glutamyltransferase and total bilirubin concentrations were unrelated to discrepant TSH values. In contrast, alkaline phosphatase (ALP) was significantly positively correlated with differences in Stratus and RIA TSH concentrations (P less than 0.001). However, this correlation explained only 34% of the observed residual variability around the estimated regression line. On average, the higher ALP values were associated with larger discrepancies between Stratus and RIA TSH values, although several samples with increased ALP did not have falsely increased Stratus TSH values. TSH measurements performed with a Stratus should be interpreted with caution in patients with abnormal biochemical markers of liver function.

scholarly journals Hepatic dysfunction in children with complicated malaria

2018 ◽  
Vol 5 (2) ◽  
pp. 547
Author(s):  
Alexander Mannu ◽  
Sunil Kumar Agarwalla ◽  
Jaishree Vasudevan ◽  
Kathir Subramaniam T. ◽  
Ahamed Basha A.
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Hepatic Dysfunction ◽  
Serum Bilirubin ◽  
Hepatic Function ◽  
Total Serum ◽  
Endemic Region ◽  
Complicated Malaria ◽  
Function Test ◽  
Moderate Elevation

Background: Complicated malaria caused by Plasmodium falciparum alone or with P. vivax can lead to multi organ dysfunction. There is a paucity of studies about hepatic dysfunction in children with complicated malaria. Hence, this retrospective study was done to find out the clinico-biochemical profile of children with complicated malarial hepatic dysfunction from a malaria endemic region of India. Further, liver function test (LFT) response to Artemisinin-based combination therapy (ACT) i.e. artesunate + sulfadoxine-pyrimethamine therapy in the malarial hepatic dysfunction children was assessed. Methods: Out of 203 children confirmed to have malaria, 60 children were found to have complicated malaria with jaundice as per WHO malaria guidelines (total serum bilirubin >3 mg%). Physical examination, malaria related biochemical and ultra-sonographic findings were noted. All the children were found to be uniformly on ACT as per institute protocol adapted from WHO guidelines. Biochemical parameters of hepatic function were compared between day 1 and 4.Results: Presentations were fever, pallor and clinical jaundice in 100%, reddish urine in 63.3%, tender hepatomegaly in 100% and splenomegaly in 81.7% of the study population. Liver function test showed mild to moderate elevation of serum bilirubin and enzymes with remarkable recovery noticed with the use of ACT in all the study subjects.Conclusions: Clinical presentations of malarial hepatic dysfunction although mimics viral hepatitis, LFT showed mild to moderate elevation only. Further, ACT therapy was found effective in the management of all children with hepatic dysfunction in complicated malaria.

Liver Function Changes in Hemorrhagic Hypotension

1957 ◽  
Vol 189 (3) ◽  
pp. 616-620
Author(s):  
Roland A. Manfredi ◽  
Raymond C. Ingraham
Keyword(s):  
Blood Pressure ◽  
Alkaline Phosphatase ◽  
Liver Function ◽  
Urinary Excretion ◽  
Mean Arterial Blood Pressure ◽  
Serum Alkaline Phosphatase ◽  
Hemorrhagic Hypotension ◽  
Arterial Blood ◽  
The Mean ◽  
The Rose

Hemorrhagic hypotension was induced in a series of 10 animals by reducing the mean arterial blood pressure to 40 mm Hg for 90 minutes producing a mean bleeding volume of 57.5 cc/kg. The urinary excretion of galactose, the Rose Bengal clearance and the serum alkaline phosphatase show a definite alteration of liver function in these animals. In the animals that survived, this depression of liver function was reversible and returned to normal by the 10th day.

scholarly journals Dynamics of Biochemical and Cytological Parameters of Rat Blood in Simulated Chronic Alimentary Methionine-Induced Homocysteinemia

Biomeditsina ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 46-57
Author(s):  
K. A. Pazinenko  ◽  
N. N. Chuchkova ◽  
M. V. Smetanina ◽  
O. A. Pazinenko ◽  
K. E. Panteleev ◽  
...  
Keyword(s):  
Amino Acids ◽  
Alkaline Phosphatase ◽  
Liver Function ◽  
Blood Lipids ◽  
Liver Enzymes ◽  
Rat Blood ◽  
Liver Tests

Under the conditions of a chronic methionine diet (daily addition of amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, the dynamics of liver tests, infl ammatory changes in the blood and blood lipids was monitored. It was found that a methionine diet (MD) leads, starting from 4 weeks of MD, to medium hyperhomocysteinemia, an increase in liver enzymes (AsAT – 1.73, AlAT – 1.5 times, p<0.05) and bilirubin (by 62.25%), which indicates the formed hepatopathy. Further (12 weeks of MD), the condition is aggravated by an abnormality of excretory liver function and the development of cholestasis (an increase in alkaline phosphatase by 1.65, bilirubin – by 3.31 times, p<0.05).

scholarly journals Alteration of Liver Function in Preeclampsia and Eclampsia

2013 ◽  
Vol 12 (3) ◽  
pp. 9-10
Author(s):  
Dilip Kumar Bhowmik ◽  
Rafia Akhtari ◽  
Sadhu Uttam Kumar ◽  
Madhusudan Saha ◽  
Dipal Krishna Adhikary
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Serum Bilirubin ◽  
Reference Value ◽  
Normal Pregnancy ◽  
Fetal Outcome ◽  
Medical College ◽  
Liver Function Impairment ◽  
Function Impairment ◽  
Normal Reference Value

Introduction: Abnormal liver function in patients with PET and eclampsia affect both maternal and fetal outcome negatively. This study was done to see change of liver function in comparison to normal pregnancy and normal reference value. Methods: Consecutive 47 patients of PET and eclampsia were taken as cases and 35 normal expectant mother were enrolled as controls. ALT, AST, alkaline phosphatase, serum bilirubin, serum creatinine and urine for albumin of patients andnormal pregnant women were tested and compared. Results: ALT, AST, S. Bilirubin, Alkaline phoshatase levels were elevated with more proteinuria among patients with PET and eclampsia, but ALT and alkaline phosphatase levels and level of proteinuria were significantly higher. Conclusions: Liver function impairment is very common in pre-eclampsia and eclampsia.Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 9-10

scholarly journals Possible hepatotoxicity of chronic marijuana usage

2004 ◽  
Vol 122 (3) ◽  
pp. 110-116 ◽  
Author(s):  
Paulo Borini ◽  
Romeu Cardoso Guimarães ◽  
Sabrina Bicalho Borini
Keyword(s):  
Alkaline Phosphatase ◽  
Illicit Drugs ◽  
Medical Literature ◽  
Drug Intake ◽  
Potential Complication ◽  
Total Proteins ◽  
Prothrombin Activity ◽  
Gamma Glutamyltransferase ◽  
Study Setting ◽  
Transversal Study

CONTEXT: Hepatotoxicity is a potential complication from the usage of various illicit drugs, possibly consequent to their liver metabolism, but information on this is scarce in the medical literature. OBJECTIVE: To study the occurrence of clinical and laboratory hepatic alterations in chronic marijuana users, from the use of marijuana on its own or in association with other legal or illicit drugs. TYPE OF STUDY: transversal study SETTING: Hospital Espírita de Marília, Marília, São Paulo, Brazil PARTICIPANTS: The study was made among 123 patients interned in the Hospital Espírita de Marília from October 1996 to December 1998, divided into 3 groups: 26 (21%) using only marijuana, 83 (67.5%) using marijuana and crack, and 14 (11.4%) consuming marijuana and alcohol. PROCEDURES AND MAIN MEASUREMENTS: Patients were examined clinically with special emphasis on types of drugs used, drug intake route, age when consumption began, length and pattern of usage, presence of tattooing, jaundice, hepatomegaly and splenomegaly. Serum determinations of total proteins, albumin, globulin, total and fractions of bilirubin, aspartate (AST) and alanine (ALT) aminotransferases, alkaline phosphatase (AP), gamma-glutamyltransferase and prothrombin activity were performed. RESULTS: Among users of only marijuana, hepatomegaly was observed in 57.7% and splenomegaly in 73.1%, and slightly elevated AST (42.3%), ALT (34.6%) and AP (53.8%). The three groups did not differ significantly in the prevalence of hepatomegaly, splenomegaly and hepatosplenomegaly. The group using both marijuana and alcohol showed the highest prevalence of alterations and highest levels of aminotransferases. Mean AP levels were above normal in all groups. CONCLUSIONS: Chronic marijuana usage, on its own or in association with other drugs, was associated with hepatic morphologic and enzymatic alterations. This indicates that cannabinoids are possible hepatotoxic substances.

scholarly journals Study of Liver Function Test in Cirrhotic Patient

2021 ◽  
Vol 28 (2) ◽  
pp. 190-191
Author(s):  
Md Nasir Uddin ◽  
Nur Wa Bushra Jahan ◽  
Kamal Sultan ◽  
Rumana Nushrat ◽  
Md Julfiker Ali ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Cirrhotic Patient ◽  
Serum Bilirubin ◽  
Income Group ◽  
College Hospital ◽  
Medical College ◽  
Function Test ◽  
Cirrhosis Of Liver ◽  
Medical University

Aim: The study was carried out to see the Serum Bilirubin, ALT, AST and Alkaline Phosphatase as liver function in liver cirrhotic patient. Method: The study was carried out among 50 well-compensated patients of cirrhosis of liver irrespective of their age, sex, residence & income group. Patient was randomly selected while they were hospitalized in Dhaka Medical College Hospital, Sir Salimullah Medical College & Mitford Hospital and Bangabandhu Sheikh Mujib Medical University. Result: Serum Bilirubin, AST, ALT and Alkaline Phosphatase level were done in 50 (fifty) cirrhotic patient out of whom 38 were male and 12 were female. Mild to severe level of serum bilirubin were documented in 50% patients. Two-fold and fourfold rise of ALT were formed in 48% and 10% cirrhotic patient respectively. Similar pattern of rise of AST also shown in 50% cirrhotic patient. Alkaline Phosphatase value was normal in 92% patient and of 08% two-fold rise of Alkaline Phosphatase Alkaline Phosphatase. J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 190-191

Biochemical and Morphological Parameters of Taurolithocholate-Induced Cholestasis

1971 ◽  
Vol 49 (12) ◽  
pp. 1078-1091 ◽  
Author(s):  
Brian G. Priestly ◽  
Michel G. Côté ◽  
Gabriel L. Plaa
Keyword(s):  
Alkaline Phosphatase ◽  
Bile Flow ◽  
Serum Bilirubin ◽  
Bile Duct Ligation ◽  
Serum Alkaline Phosphatase ◽  
Taurocholic Acid ◽  
Isolated Perfused Rat Liver ◽  
Morphological Parameters ◽  
Perfused Rat Liver ◽  
Duct Ligation

Intravenous injection of sodium taurolithocholate (NaTL) into rats produces a dose-related cholestatic response. A dose of 100 mg/kg was chosen to study the temporal effects on bile flow, serum bilirubin (SB) concentrations, serum transaminase (SGPT) activity, and serum alkaline phosphatase (SAP) activity. Cessation of bile flow after NaTL injection or bile duct ligation (B.D.L.) was accompanied by progressive elevations of SB and SGPT; after NaTL, these parameters reached maximal values at a time when bile flow was returning to normal. Changes in SAP were similar in both NaTL-treated and B.D.L. groups. Elevation of SGPT and SB was also seen when a combination of NaTL and taurocholic acid (TC) was injected, although cholestasis was not produced. TC alone produced similar changes. NaTL injection produced changes in hepatic ultrastructure, of which the most marked were dilatation of biliary canaliculi and the endoplasmic reticulum. The disruption was marked at 12 h and was reversed at 24 h. This correlated with changes in SGPT and microsomal function as measured by zoxazolamine paralysis time. TC also produced elevation of SGPT in the isolated perfused rat liver. The above changes are consistent with obstruction of the biliary tract by NaTL precipitation. However, the data also indicate that a combination of NaTL and TC can elicit hepatocyte disturbances without causing a diminution in bile flow.

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