scholarly journals Advances in radiochemotherapy in the treatment of head and neck cancer

2004 ◽  
Vol 59 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Daniel Herchenhorn ◽  
Fernando Luiz Dias
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Locally Advanced ◽  
Molecular Therapy ◽  
Functional Evaluation ◽  
Advanced Stages ◽  
Surgical Salvage

New advances are being incorporated into the radiochemotherapy treatment of squamous cell carcinoma of the head and neck. Although the overall prognosis is poor in advanced stages, the possibility of incorporating combined protocols of chemotherapy and radiotherapy for organ preservation or for palliation in cases of recurrent/locally advanced stages that are not good surgical candidates must not be forgotten. In this context, there is an urgent need to incorporate quality of life questionnaires and functional evaluation into organ-preservation studies, as well as to assure the importance of surgical salvage after radiotherapy and chemotherapy protocols. The authors provide an extensive review of the advances occurring in the nonsurgical treatment of head and neck cancer. Special attention is given to different radiotherapy protocols, new chemotherapy combinations, molecular markers, and molecular therapy as well as the possibility of incorporating re-irradiation and adjuvant therapy after surgery.

Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer

2015 ◽  
Vol 191 (6) ◽  
pp. 501-510 ◽  
Author(s):  
Silke Tribius ◽  
Marieclaire Raguse ◽  
Christian Voigt ◽  
Adrian Münscher ◽  
Alexander Gröbe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
One Year

Impact of systemic treatment associated to radiotherapy on quality of life in locally advanced head and neck cancer patients in Brazil: Prospective real-world data study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17563-e17563
Author(s):  
Marcos Antonio Santos ◽  
Luis Felipe Oliveira e Silva ◽  
Hugo Fontan Kohler ◽  
Otavio Curioni ◽  
Ricardo Alencar Vilela ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Alcohol Consumption ◽  
Head And Neck ◽  
Neck Cancer ◽  
Real World ◽  
Systemic Treatment ◽  
Locally Advanced ◽  
Advanced Head

e17563 Background: the purpose of this study was to compare quality of life (QoL) and overall survival (OS) in patients with locally advanced head and neck cancer treated with radiotherapy only (RT), chemoradiotherapy with cisplatin (CT-RT) or RT with cetuximab (CET-RT). Methods: in this real-world, multi-institutional and prospective study, QoL outcomes were assessed using EORTC QLQ-C30 and QLQ-H&N43 questionnaires. Patients were treated according to each participating institution’s protocol. The Item Response Theory was used to generate a global QoL score, based on the 71 questions of both forms. Questionnaires were completed before treatment and every three months, thereafter. Survival was calculated using the Kaplan-Meyer method, and groups were compared by the log-rank test. The impact of the treatment modalities on QoL was analyzed using multivariate regression analyses. Results: Six hundred and twenty-six patients, with tumors located at the oral cavity (36%), oropharynx (30%), larynx (21%), hypopharynx (9%) and nasopharynx (4%) were included. Median follow up was 10.2 months. RT was delivered to 39% of the patients while 58% received CT-RT and 3% received CET-RT. Patients submitted to surgery were not included. OS was higher when systemic treatment was added to RT (median OS CET-RT: 21.9 months and CT-RT: 24.3 months, versus 14.2 months with RT, p < 0.05). A decrease in QoL during treatment was observed in all patients’ groups, but CT-RT had a statistically significant negative impact on QoL when compared to CET-RT (p = 0.02). An important limitation of the study is the low number of patients that received this last treatment modality, what is, probably, a result of local policies on reimbursement. Other factors that influenced QoL were alcohol consumption (better QoL for patients with no history of chronic alcohol consumption, p = 0.007) and radiotherapy technique (better QoL for patients treated with intensity-modulated RT, when compared to conformal RT, p < 0.001). Conclusions: We observed, as expected, better OS with systemic therapy, when associated to RT. A decrease in QoL was detected, as well, during treatment, but a less pronounced decrease was seen in patients receiving CET-RT, when compared to CT-RT. More studies are needed to confirm the QoL improvement in patients submitted to this last treatment approach.

scholarly journals Salvage Surgery in Head and Neck Cancer

2021 ◽  
pp. 233-246
Author(s):  
Stijn van Weert ◽  
Sat Parmar ◽  
C. René Leemans
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Salvage Surgery ◽  
Transoral Robotic Surgery ◽  
Shared Decision ◽  
Surgery Complications

AbstractSalvage surgery (SS) in head and neck cancer is considered a last resort treatment after failure of organ preservation treatments. It offers challenges to the patients and the surgeon. The outcome of SS is often uncertain in terms of survival and quality of life. This paper offers an overview of evolution in SS, tumor and patient factors to be considered, challenges in reconstructive surgery, complications of SS and the changing landscape with regard to increasing incidence of human papillomavirus positive tumours, the role of transoral robotic surgery, the importance of multidisciplinary management and shared decision making.

Taxane-based chemoirradiation for organ preservation with locally advanced head and neck cancer: Results of a phase II multi-institutional trial

Head & Neck ◽  
2007 ◽  
Vol 29 (4) ◽  
pp. 315-324 ◽  
Author(s):  
Anthony J. Cmelak ◽  
Barbara A. Murphy ◽  
Brian Burkey ◽  
Stacy Douglas ◽  
Yu Shyr ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Locally Advanced ◽  
Advanced Head

scholarly journals QUALIDADE DE VIDA EM DEGLUTIÇÃO E CÂNCER DE CABEÇA E PESCOÇO: REVISÃO DE LITERATURA

2017 ◽  
Vol 8 (1) ◽  
pp. 26
Author(s):  
Manoela Carrera ◽  
Alena Ribeiro Alves Peixoto Medrado ◽  
Gabriela Botelho Martins ◽  
Hayana Ramos Lima ◽  
Raquel De Santana Oliveira Marques ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Deglutition Disorders ◽  
Head And Neck ◽  
Neck Cancer ◽  
Treatment Modality ◽  
Well Being ◽  
Swallowing Function ◽  
Advanced Stages

Objective: This study aimed to review the literature on the quality of life related to swallowing of patients with head and neck cancer. Methods: We searched for studies describing the physiology of swallowing and aspects involved in dysphagia, such as definition, causes and their impact on quality of life. We used the electronic databases Pubmed, Medline, Scielo, books, as well as articles identified in the references. Results: Deglutition disorders may occur due to disease and / or treatment modality, persisting during or after termination of treatment. The frequency and severity of dysphagia will depend on the modality of treatment used, location and stage of the tumor, when involved in structures that participate in swallowing. Patients with tumors in more advanced stages and located in the pharynx try to present worsening of swallowing function. Such factors may directly affect swallowing and quality of life of the patient, especially in family, social and lifestyle relationships. Conclusion: Although it does not replace clinical and instrumental evaluations, investigating the quality of life in swallowing may contribute to assess specific aspects of patient well-being that are not contemplated.

Sign in / Sign up

Export Citation Format

Share Document